Zhongnan Fang

ORCID: 0000-0003-3463-7766
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About
Contact & Profiles
Research Areas
  • Neural dynamics and brain function
  • Photoreceptor and optogenetics research
  • Advanced MRI Techniques and Applications
  • Medical Imaging Techniques and Applications
  • Functional Brain Connectivity Studies
  • Radiomics and Machine Learning in Medical Imaging
  • Advanced Fluorescence Microscopy Techniques
  • Cardiac Imaging and Diagnostics
  • Advanced Image Processing Techniques
  • Geological Modeling and Analysis
  • Neuroscience and Neuropharmacology Research
  • Medical Image Segmentation Techniques
  • Energy, Environment, Economic Growth
  • Photoacoustic and Ultrasonic Imaging
  • Neuroscience and Neural Engineering
  • Advanced Neuroimaging Techniques and Applications
  • Radiation Dose and Imaging
  • Image Processing Techniques and Applications
  • Advanced Vision and Imaging
  • MRI in cancer diagnosis
  • Energy and Environment Impacts
  • Artificial Intelligence in Healthcare and Education
  • EEG and Brain-Computer Interfaces
  • Radiology practices and education
  • Energy, Environment, and Transportation Policies

Stanford University
2013-2025

VIS Systems (Poland)
2018

University of California, Los Angeles
2013-2015

Xiamen University
2015

To develop a super-resolution technique using convolutional neural networks for generating thin-slice knee MR images from thicker input slices, and compare this method with alternative through-plane interpolation methods.We implemented 3D network entitled DeepResolve to learn residual-based transformations between high-resolution lower-resolution thick-slice at the same center locations. was trained 124 double echo in steady-state (DESS) data sets 0.7-mm slice thickness tested on 17...

10.1002/mrm.27178 article EN Magnetic Resonance in Medicine 2018-03-26

Over 85 million computed tomography (CT) scans are performed annually in the US, of which approximately one quarter focus on abdomen. Given current shortage both general and specialized radiologists, there is a large impetus to use artificial intelligence alleviate burden interpreting these complex imaging studies while simultaneously using images extract novel physiological insights. Prior state-of-the-art approaches for automated medical image interpretation leverage vision language models...

10.21203/rs.3.rs-4546309/v1 preprint EN Research Square (Research Square) 2024-06-28

Central thalamus plays a critical role in forebrain arousal and organized behavior. However, network-level mechanisms that link its activity to brain state remain enigmatic. Here, we combined optogenetics, fMRI, electrophysiology, video-EEG monitoring characterize the central thalamus-driven global networks responsible for switching state. 40 100 Hz stimulations of caused widespread activation forebrain, including frontal cortex, sensorimotor striatum, transitioned asleep rats. In contrast,...

10.7554/elife.09215 article EN cc-by eLife 2015-12-10

Background Super‐resolution is an emerging method for enhancing MRI resolution; however, its impact on image quality still unknown. Purpose To evaluate super‐resolution using quantitative and qualitative metrics of cartilage morphometry, osteophyte detection, global blurring. Study Type Retrospective. Population In all, 176 studies subjects at varying stages osteoarthritis. Field Strength/Sequence Original‐resolution 3D double‐echo steady‐state (DESS) DESS with 3× thicker slices...

10.1002/jmri.26872 article EN Journal of Magnetic Resonance Imaging 2019-07-16

Potential approaches for abbreviated knee MRI, including prospective acceleration with deep learning, have achieved limited clinical implementation.

10.2214/ajr.20.24172 article EN American Journal of Roentgenology 2020-08-05

A fine-tuned, open-source large language model (Mistral-7B; Mistral AI) effectively extracted clinical history elements from imaging orders with substantial agreement radiologists and rivaled a closed-source (GPT-4 Turbo; OpenAI).

10.1148/radiol.241051 article EN Radiology 2025-02-01

To propose a novel compressed sensing (CS) high spatial resolution functional MRI (fMRI) method and demonstrate the advantages limitations of using CS for fMRI.A randomly undersampled variable density spiral trajectory enabling an acceleration factor 5.3 was designed with balanced steady state free precession sequence to achieve data acquisition. A modified k-t SPARSE then implemented applied strategy optimize regularization parameters consistent, quality reconstruction.The proposed improves...

10.1002/mrm.25854 article EN cc-by-nd Magnetic Resonance in Medicine 2015-10-29

10.1016/j.rser.2015.07.017 article EN Renewable and Sustainable Energy Reviews 2015-07-25

The investigation of the functional connectivity precise neural circuits across entire intact brain can be achieved through optogenetic magnetic resonance imaging (ofMRI), which is a novel technique that combines relatively high spatial resolution high-field fMRI with precision stimulation. Fiber optics enable delivery specific wavelengths light deep into in vivo are implanted regions interest order to specifically stimulate targeted cell types have been genetically induced express...

10.3791/53346 article EN Journal of Visualized Experiments 2016-04-19

The investigation of the functional connectivity precise neural circuits across entire intact brain can be achieved through optogenetic magnetic resonance imaging (ofMRI), which is a novel technique that combines relatively high spatial resolution high-field fMRI with precision stimulation. Fiber optics enable delivery specific wavelengths light deep into in vivo are implanted regions interest order to specifically stimulate targeted cell types have been genetically induced express...

10.3791/53346-v article EN Journal of Visualized Experiments 2016-04-19

Over 85 million computed tomography (CT) scans are performed annually in the US, of which approximately one quarter focus on abdomen. Given current radiologist shortage, there is a large impetus to use artificial intelligence alleviate burden interpreting these complex imaging studies. Prior state-of-the-art approaches for automated medical image interpretation leverage vision language models (VLMs). However, VLMs generally limited 2D images and short reports, do not electronic health record...

10.48550/arxiv.2406.06512 preprint EN arXiv (Cornell University) 2024-06-10

Deep-learning (DL) can be used to extend compressed sensing (CS) learn the regularization function in a data-driven manner. In contrast, super resolution (SR) algorithms have been transform rapidly-acquired low-resolution images into higher-resolution images. This work compares DL-CS with DL-SR for accelerated MRI on test dataset of 50 patients conventional image quality metrics and clinically-relevant quantitative T 2 relaxation measurements. We demonstrate that DLCS approaches outperform DLSR MRI.

10.58530/2022/1873 article EN Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition 2023-08-03

Obtaining magnetic resonance images (MRI) with high resolution and generating quantitative image-based biomarkers for assessing tissue biochemistry is crucial in clinical research applications. How- ever, acquiring requires signal-to-noise ratio (SNR), which at odds high-resolution MRI, especially a single rapid sequence. In this paper, we demonstrate how super-resolution can be utilized to maintain adequate SNR accurate quantification of the T2 relaxation time biomarker, while...

10.48550/arxiv.1808.04447 preprint EN other-oa arXiv (Cornell University) 2018-01-01
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