Alzheimer’s disease is first characterised by memory loss related to the central cholinergic system alteration. Available drugs provide symptomatic treatment with known side effects. The present study aimed evaluate properties of Carissa edulis aqueous extract on a Scopolamine mouse model as an attempt search for new compounds against disease-related impairment. Memory impairment was induced administration 1 mg/kg (i.p.) 7 days, and mice were treated extract. Behavioural studies performed...

Antiretroviral therapy (ART) has revolutionized the lives of people living with HIV/AIDS by overall improving their quality life and increasing expectancy. However, ART-associated hepatotoxicity metabolic disorders in patients are growing concerns to clinicians, especially due long-term use drugs. This study reported on phytochemical pharmacological profile hydroethanolic extracts Piper nigrum stem (PNS) evaluated its protective effect against tenofovir/lamivudine/efavirenz (TLE)-induced...

Triclisinone (2), a new ochnaflavone derivative, was isolated from the aerial parts of Triclisia gilletii, along with known drypemolundein B (1) and eight other compounds. The chemical shifts have been partially revised based on reinterpretation NMR spectroscopic data. secondary metabolites are composed of: (+)-nonacosan-10-ol (3); stigmasterol (4), 3-O-β-D-glucopyranosylsitosterol (5), 3-O-β-D-glucopyranosylstigmasterol (6); oleanic acid (7); myricetin (8), quercetin (9) 3-methoxyquercetin...

Sorindeia nitidula (Anacardiaceae) is used by traditional practitioners to treat influenza illnesses with cephalgia and febrile aches. However, the potential active ingredients for its remarkable antioxidant, anti-HIV antitrypanosomal activities remain unexplored. The present study aims evaluate of ethyl acetate extract S. (SN) in order screen out bioactive compounds analyze their possible mechanisms action. Overall, 21 phenolic were annotated, using MS MS/MS information provided QTOF-MS. In...

A new C-glycosylflavone, apigenin 7-methyl ether 6-C-[β-xylopyranosyl-(1→3)-β-glucopyranoside] named distemonanthoside was isolated from the stem bark of Distemonanthus benthamianus Baill., Fabaceae, along with six known compounds, sitosterol 3-O-β-d-glucopyranoside, 4-methoxygallic acid, syringic quercetin, 6″-O-acetylvitexin, quercetin 3-O-β-d-glucopyranoside. The structures those compounds and others were determined through spectral analyses. Compounds distemonanthoside, acid tested...

Context: The roots of Lophira lanceolata Van Tiegh. Ex Keay (Ochnaceae) have numerous medicinal values in the Central African region. Even though MeOH extract has shown antimycobacterial activities, constituents responsible for this inhibitory activity remain unknown.Objective: Phytochemical investigation root L. and determination activities that against growth Mycobacterium tuberculosis.Materials methods: Column chromatography was used to provide bioactive phytoconstituents. Those compounds...

The chemical investigation of the extract dried leaves Rauvolfia caffra (Sond) (synonym macrophylla) (Apocynaceae) led to isolation a new glycoside derivative, rauvolfianine (1) as well six known compounds: oleanolic acid (2), sitosterol-3-O-β-D-glucopyranoside (3), betulinic (4), vellosimine (5), sarpagine (6) and D-fructofuranosyl-β-(2→1)-α-D-glucopyranoside (7). Compounds 1, 2, 3, 4 7 were evaluated for antitubercular activity. 1 2 most active (MIC = 7.8125 31.25 μg/mL) towards Isoniazid...

Tuberculosis (TB) is an infectious disease caused by the Mycobacterium tuberculosis (M. tuberculosis) complex, resposible for health problems in developing countries. In Africa, various medicinal plants are traditionally used to treat TB. The aim of this study carry out phytochemical screening, evaluate antimycobacterial activity crude extracts three present Cameroon (Zingiber officinale, Vitellaria paradoxa and Alstonia boonei) acute toxicity hydroethanolic extract paradoxa. screening was...

Background: In the recent years, proliferation of multi-drug-resistant and extensively drug-resistant strain to tuberculosis (TB) suggest that efforts are required find alternative treatments. The designed study aimed show effects essential oils (EO) from Drypetes gossweileri stem barks on Mycobacterium cell membrane release DNA synthesis. Methods: minimal inhibitory concentration (MIC) bactericidal (MBC) were determined against two clinical isolates (IS53 IS310) reference H37Rv ATCC 27294...

Abstract Background Chemical and pharmacological investigations were performed on the stems of Cordia batesii (Boraginaeae); chemical studies included quantum calculations applied a newly described compound. Results A new derivative allantoin ( 1 ) named batesiin 2 was characterized. Thirteen other known compounds involving either isolated or identified. GC–MS enabled identification six from fraction containing essential oil. MeOH extract some tested in vitro against Pf 7G8 CQS Dd2 CQR...

This study evaluated the antibacterial efficacy of methanolic extracts isolated endophytic fungi from stem barks and leaves Alstonia boonei De Wild Greenwayodendron suaveolens (Engl. Diels) Verdc. subsp. Suaveolens against Klebsiella pneumoniae ATCC 43816, Haemophilus influenzae 49247, Pseudomonas aeruginosa 27853, Escherichia coli 35218, responsible for causing pneumonia. The were characterized in Potato Dextrose Agar (PDA), Sabouraud (SDA), Czapek Dox (CDA) media. their tested vitro...

<title>Abstract</title> <italic>Sorindeia nitidula</italic> is used by traditional practitioners to treat influenza illnesses with cephalgia and febrile aches. However, the potential active ingredients for its remarkable antioxidant, anti-HIV antitrypanosomal activities remain unexplored. The present study aims evaluate of ethyl acetate extract <italic>S. (SN) in order screen out bioactive compounds analyze their possible mechanisms action. Overall, 21 phenolic were annotated, using MS MS/MS...

Pneumonia, a respiratory infection induces acute or chronic inflammation, characterized by increased activity of lymphocytes and neutrophils, thus generating oxygen-free radicals that decrease the endogenous antioxidants defence system. The aim this experimental study focused on capacity nontoxic aqueous, hydroethanolic ethanolic extracts Greenwayodendron suaveolens (Engl. & Diels) Verdc. subsp. to regulate free reactive species protein inflammation generated infectious disease....

Abstract Background Klebsiella pneumoniae has become one of the major threats to public health as it causes nosocomial and community-acquired infections like lobar pneumonia. This infection acute inflammation in lung, characterized by recruitment polymorphonuclear cells, generating free radicals, decreasing endogenous antioxidant balance system. Many experimental studies have focused on induction, progression resolution up its peak, but these documented processes remain highly random their...

A new lupane-type triterpene, 2α,3β-dihydroxylupan-29-oic acid (1), and one ceramide derivative: (2S*,2'R*,3S*,4R*,5R*,7'E,11E,12'E,20E)-N-[2'-hydroxyoctadeca-6,11-dienoyl]-2-aminohexacosa-11,20-diene-1,3,4,5-tetrol (2) were isolated from the ethyl acetate fraction obtained methanol extract of stem barks Cassia arereh together with seven known compounds. Their structures characterized using two-dimensional NMR, mass spectrometry, compared reported data. To date, this is first report...

Aims: The aim of this study was to evaluate in vitro the antifungal activity Dissotis multiflora (Melastomataceae) and Paullinia pinnata (Sapindaceae) leaves extracts on six species Candida.&#x0D; Study Design: This an experimental study.&#x0D; Duration Place Study: Between March August 2017, Department Microbiology, Microbiology laboratory, University Yaoundé I. Bacteriology Teaching Hospital (YUHC).&#x0D; Methodology: fungal strains were isolated from vaginal swab women at sampling unit...

The present work aimed to determine the phytochemical components and evaluate in vitro anti-inflammatory anti-mycobacterial effects of hydroethanolic extracts Allium sativum L bulbs, Drypetes gossweileri S. MOORE stem-barks Pentadiplandra brazzeana Baill roots against several resistant strains Mycobacterium tuberculosis. screenings were carried out according colorimetric precipitation tests reveal presence compounds. evaluated using Bovine Serum Albumin denaturation proteinase inhibitory...