A5055573345- Glioma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Brain Metastases and Treatment
- Epilepsy research and treatment
- Cerebrovascular and Carotid Artery Diseases
- Fetal and Pediatric Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Cancer-related cognitive impairment studies
- Meningioma and schwannoma management
- Neuroscience and Neuropharmacology Research
- Acute Ischemic Stroke Management
- Cardiac Imaging and Diagnostics
- Pharmacological Effects and Toxicity Studies
- Cervical and Thoracic Myelopathy
- Pediatric Urology and Nephrology Studies
- Vascular Malformations Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Neonatal and fetal brain pathology
- MRI in cancer diagnosis
- Neurofibromatosis and Schwannoma Cases
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
- Radiation Dose and Imaging
- Ultrasound in Clinical Applications
- Peripheral Artery Disease Management
Austin Health
2014-2023
The University of Melbourne
2013-2022
UNSW Sydney
2022
Concord Repatriation General Hospital
2022
The Netherlands Cancer Institute
2022
The University of Sydney
2022
National Cancer Centre Japan
2022
Austin Hospital
2013-2022
Florey Institute of Neuroscience and Mental Health
2013-2022
NorthShore University HealthSystem
2017
To determine clinical and EEG features that might help identify patients with epilepsy harboring small, intrinsically epileptogenic, surgically treatable, bottom-of-sulcus dysplasias (BOSDs).Retrospective review of records, EEG, MRI, histopathology in 32 drug-resistant MRI-positive (72% 3.0 tesla), pathologically proven (type 2B cortical dysplasia) BOSDs operated at our centers during 2005-2013.Localization was frontal 19, insula 5, parietal temporal 3, on the convexity or interhemispheric...
We sought evidence of a hereditary component for hippocampal sclerosis (HS) by determining whether close relatives probands with temporal lobe epilepsy (TLE) HS also had asymptomatic or subtle variation in morphology.First-degree from 15 families which TLE and 32 age- sex-matched controls were included the study. Left right volumes T2 relaxometry measured using 3-tesla MRI.Thirty-two first-degree 3 history seizures studied. None on visual analysis relaxation times normal, excluding presence...
There is considerable difficulty in diagnosing hippocampal malrotation (HIMAL), with different criteria of variable reliability. Here we assess qualitative and quantitative HIMAL diagnosis explore the role magnetic resonance imaging (MRI)-negative temporal lobe epilepsy (TLE).We studied MRI 155 adult patients MRI-negative TLE 103 healthy volunteers, asked (1) what are features that allow a reliable HIMAL, (2) how common normal control population, (3) congruent epileptogenic side TLE.We found...
Magnetic resonance diffusion-weighted imaging (DWI) is the most accurate technique available for demonstrating acute infarction; however, false-negative DWI higher in infratentorium due to limited spatial resolution with conventional 5 mm DWI. The aim of this study was compare 3 detection infratentorial infarction.A sequence incorporated into MRI stroke protocol evaluation patients vertebrobasilar stroke-like deficits. and sequences were assessed by two neuroradiologists who blinded clinical...
Abstract Purpose Cancer-related cognitive impairment (CRCI) is a recognised adverse consequence of cancer and its treatment. This study assessed the feasibility collecting longitudinal data on cognition in patients with newly diagnosed, aggressive lymphoma undergoing standard therapy curative intent via self-report, neuropsychological assessment, peripheral markers inflammation, neuroimaging. An exploration description patterns cancer-related over course treatment recovery was also...
The adverse impact of increasing brain tumor size on the efficacy antibody-drug conjugates (ADCs) was investigated preclinically then validated with clinical data.The ADC delivery and treatment response evaluated in an EGFR-amplified patient-derived glioblastoma (GBM) model following Depatuxizumab mafadotin (Depatux-M). Biodistribution imaging studies correlated drug distribution starting volume anti-tumor activity.M12-356 a Phase I study Depatux-M patients GBM. Blinded volumetric analysis...
Introduction Cancer-related cognitive impairment (CRCI) is a distressing and disabling side-effect of cancer treatments affecting up to 75% patients. For some patients, their may be transient, but for subgroup, these symptoms can long-standing have major impact on the quality life. This paper describes protocol study: (1) assess feasibility collecting longitudinal data cognition via self-report, neuropsychological testing, peripheral markers inflammation neuroimaging (2) explore describe...
Abstract Introduction Diabetic patients with peripheral arterial disease (PAD) are challenging to assess. Non‐contrast magnetic resonance angiography (MRA) offers a safe alternative in renal impairment. The study objective is evaluate accuracy of lower limb quiescent‐interval single‐shot (QISS) MRA and pedal QISS‐arterial spin‐labelled (ASL) for detection significant stenosis diabetic PAD. Methods Combined QISS QISS‐ASL was performed 32 PAD (20 male, 12 female; mean 69 years; 8 critical...
MRI and PET imaging enables subgroups of temporal lobe epilepsy (TLE) to be defined on the basis structural pathology. Few studies have examined variation in electroclinical seizure spread patterns based findings. We performed a retrospective cohort study investigate differences among 3 specific groups TLE: MRI-negative PET-positive TLE (MRI-negative TLE), lesion (lesional unilateral hippocampal sclerosis (HS-TLE).Patients with an diagnosis who had video-scalp EEG recordings seizures were...
Abstract Introduction Minimising radiation exposure in paediatric imaging examinations whilst maintaining acceptable diagnostic quality continues to present a challenge. The aims of this study were assess institutional compliance CT brain ( CTB ) performed an adult hospital with ARPANSA dose recommendations and compare qualitative acceptability objective parameters dose. Methods A retrospective review 115 consecutive was undertaken at tertiary referral centre Australia over 2‐year period....
The purpose of this study is to evaluate feasibility, image quality (IQ), and accuracy noncontrast hybrid arterial spin labeling (NoHASL) magnetic resonance angiography (MRA) compared with time flight (TOF) MRA contrast-enhanced (CE) in patients known/suspected cerebrovascular ischemia.Thirty inpatients were imaged at 1.5 T. Two neuroradiologists assessed 630 intracranial segments for IQ (1, nondiagnostic; 3, satisfactory diagnosis; 5, excellent). Hemodynamically significant stenosis (>50%)...
BACKGROUNDAdverse biophysical factors (abnormal vessels and increased interstitial pressure) are in larger brain tumors, which negatively impacts penetration of antibody drug conjugates (ADC). The tumour-specific anti-EGFR ADC, depatuxizumab mafadotin (depatux-m), demonstrated encouraging activity a Phase 1 glioblastoma study (M12-356 study, NCT01800695). impact tumour size on depatux-m efficacy was investigated. PRECLINICAL STUDY: Forty mice were engrafted with patient derived xenografts...
Abstract Purpose Cancer-related cognitive impairment (CRCI) is a recognised adverse consequence of cancer and its treatment. This study assessed the feasibility collecting longitudinal data on cognition in patients with newly diagnosed, aggressive lymphoma undergoing standard therapy curative intent via self-report, neuropsychological assessment, peripheral markers inflammation neuroimaging. An exploration description patterns cancer-related over course treatment recovery was also explored....
A 53 year old man with a background of castrate-sensitive prostate cancer on intermittent androgen deprivation therapy (ADT) presented right sixth nerve palsy secondary to solitary petroclival lesion involving adjacent dura and bone.The clinical imaging characteristics the were consistent number differential diagnoses (including metastatic cancer, meningioma chondrosarcoma).The patient initially declined biopsy ADT was recommenced but continued enlarge despite an excellent biochemical...
Traditional clinical markers of renal function are unreliable in people with early diabetic kidney disease (DKD). Diffusion tensor imaging (DTI) has potential to non-invasively measure disease, reflecting changes tubular microstructure. Changes cortical fractional anisotropy (cFA), medullary (mFA) mean diffusivity (cMD) and (mMD) have been reported type 2 diabetes (T2DM), including normal function.