A5068497146- Pulsars and Gravitational Waves Research
- Adaptive optics and wavefront sensing
- DNA and Nucleic Acid Chemistry
- Geophysics and Gravity Measurements
- Astronomy and Astrophysical Research
- Advanced biosensing and bioanalysis techniques
- Optical Systems and Laser Technology
- Advanced Frequency and Time Standards
- Gamma-ray bursts and supernovae
- Advanced optical system design
- Particle accelerators and beam dynamics
- RNA Interference and Gene Delivery
- Particle Accelerators and Free-Electron Lasers
- Plant Gene Expression Analysis
- Radio Astronomy Observations and Technology
- Geophysics and Sensor Technology
- Genomics, phytochemicals, and oxidative stress
- Parkinson's Disease Mechanisms and Treatments
- Seismic Waves and Analysis
- Solar and Space Plasma Dynamics
- CCD and CMOS Imaging Sensors
- Advanced Memory and Neural Computing
- Cosmology and Gravitation Theories
- Ferroelectric and Negative Capacitance Devices
- Magnetic confinement fusion research
Institut de Recherche sur les Lois Fondamentales de l'Univers
2024
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2024
CEA Paris-Saclay
2024
Polytechnique Montréal
2022-2024
Université de Bretagne Occidentale
2021-2024
United States Military Academy
2011-2023
IMT Atlantique
2021-2022
Université de Montréal
2022
Laboratoire des Sciences et Techniques de l’Information de la Communication et de la Connaissance
2021
Institut Polytechnique de Bordeaux
2020
The antioxidant response element (ARE) is a cis-acting regulatory enhancer found in the 5' flanking region of many phase II detoxification enzymes. Up-regulation ARE-dependent target genes known to have neuroprotective effects; yet, mechanism activation largely unknown. By screening an arrayed collection approximately 15,000 full-length expression cDNAs human neuroblastoma cell line IMR-32 with ARE-luciferase reporter, we identified several not previously associated ARE activation. A subset...
Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein which contains domain and GTPase among other regions. Individuals possessing gain of function mutations in the such as most prevalent G2019S mutation have been associated with an increased risk for development Parkinson's disease (PD). Given this genetic validation inhibition LRRK2 activity potential means affecting progression, our team set out to develop inhibitors test hypothesis. A high throughput screen compound...
Electrospray ionization mass spectrometry (ESI-MS) and spectroscopic studies in solution were used to evaluate the self-association, G-quadruplex DNA binding, selectivity of a series perylene diimides (PDIs) (PIPER, Tel01, Tel11, Tel12, Tel18) or benzannulated diimide ligands (Tel34 Tel32). Fluorescence resonance light scattering spectra Tel32, Tel34 reveal that these analogs undergo self-association solution. UV-Vis fluorescence titrations with G-quadruplex, duplex, single-stranded...
Human telomeres are comprised of d(TTAGGG) repeats that capable forming G-quadruplex DNA structures. Ligands bind to and stabilize these structures potential inhibitors the cancer cell-associated enzyme telomerase. Other biological uses targeting ligands have been proposed. One particularly challenging aspect contemplated is their selectivity for versus double-stranded We previously reported observation two structurally related 3,4,9,10-perylenetetracarboxylic acid diimide-based ligands,...
A seismic isolation system for the proposed 'Advanced LIGO' detector upgrade is under development. It consists of a two-stage in-vacuum active platform that supported by an external hydraulic actuation stage. full-scale preliminary-design technology demonstrator has been assembled and being tested at Stanford's engineering test facility. Unanticipated excess ground motion from local human activity LIGO Livingston prompted accelerated development stage installation use in initial detector. As...
Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are most common genetic cause of Parkinson's disease (PD) and both autosomal dominant familial sporadic PD. Currently, physiological pathogenic activities LRRK2 poorly understood. To decipher biological functions LRRK2, including genes pathways modulated by activity vivo, we assayed genome-wide mRNA expression brain peripheral tissues from knockout (KO) hyperactive G2019S (G2019S) transgenic mice. Subtle but significant differences...
Parkinson's disease, a progressive neurodegenerative disorder, is characterized by loss of midbrain dopaminergic neurons. The etiology sporadic disease unknown; however, oxidative stress thought to play major role in pathogenesis. Little known regarding the transcriptional changes that occur disease. antioxidant response element cis-acting enhancer sequence upstream many phase II detoxification and genes. Here we show 6-hydroxydopamine, mitochondrial inhibitor used model activates both...
On the basis of growing evidence for G-quadruplex DNA structures in genomic and presumed need to resolve these replication, unwinding ability a prototypical replicative helicase, SV40 large T-antigen (T-ag), was investigated. Here, we demonstrate that this helicase activity is robust comparable duplex T-ag. Analysis genome demonstrates presence sequences may form intramolecular G-quadruplexes, which are natural substrates A number G-quadruplex-interactive agents as well new perylene diimide...
The hydraulic external pre-isolator (HEPI) is the first six degrees of freedom active seismic isolation system implemented at Laser Interferometer Gravitational Wave Observatory (LIGO). Implementation was completed LIGO Livingston (LLO) prior to LIGOʼs fifth science run7, successfully cutting down disturbance seen by LLOʼs suspended optics in two most prominent bands, microseism (0.1–0.3 Hz) and anthropogenic (1–3 a factor few tens. improvement contributed directly much improved duty cycle...
The Giant Magellan Telescope (GMT) is one of Extremely large telescopes, which 25m in diameter featured with two Gregorian secondary mirrors, an adaptive mirror (ASM) and a fast-steering (FSM). FSM 3.2 m built as seven 1.1 circular segments conjugated 1:1 to the 8.4m primary. guiding philosophy design segment minimize development fabrication risks ensuring set mirrors are available on schedule for telescope commissioning early operations seeing limited mode. Each contains tip-tilt capability...
Glutamate plays a key role in cognition and mood, it has been shown that inhibiting ionotropic glutamate receptors disrupts cognition, while enhancing receptor activity is pro-cognitive. One approach to elevating glutamatergic tone antagonize presynaptic metabotropic 2 (mGluR2). A desire for selectivity over the largely homologous mGluR3 motivated strategy achieve through identification of mGluR2 negative allosteric modulators (NAMs). Extensive screening optimization efforts led novel series...
The GMT adaptive secondary mirror (ASM) is based on a "segmented" concept following the primary segment layout: seven 1.05m diameter circular, independent mirrors are fed by primaries and focus to main telescope focal stations. unit's design consolidated thin mirror, contactless technology already employed in several units (MMT, LBT, Magellan, VLT one of proposed E-ELT M4 designs), but nevertheless mirror's topology reveals challenges. In particular, off-axis strongly aspheric therefore they...
The Giant Magellan Telescope (GMT), one of several next generation Extremely Large Telescopes (ELTs), is a 25.4 meter diameter altitude over azimuth design set to be built at the summit Cerro Campanas Las Observatory in Chile. primary mirror consists 7 individual 8.4 segments resulting an equivalent collecting area 21.5 single mirror. telescope structure, optics and instrumentation has rotating mass approximately 1250 metric tons stands 40 meters tall. This paper reports results our ongoing...
Matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry is an analytical method that detects macromolecules can be used for proteomic fingerprinting and taxonomic identification in arthropods. The conventional MALDI approach uses fresh laboratory-reared arthropod specimens to build a reference spectra library with high-quality standards required achieve reliable identification. However, this may not possible accomplish some groups are difficult rear under...
Modification of potent, selective metabotropic glutamate receptor 2 negative allosteric modulator (mGluR2 NAM) led to a series analogues with excellent binding affinity, lipophilicity, and suitable physicochemical properties for PET tracer convenient chemical handles incorporation 11C or 18F radiolabel. [11C]MK-8056 was synthesized evaluated in vivo demonstrated appropriate selectivity, be used as positron emission tomography mGluR2.