A5037158833- Superconducting and THz Device Technology
- Physics of Superconductivity and Magnetism
- Particle Detector Development and Performance
- Inflammatory Bowel Disease
- Advanced Semiconductor Detectors and Materials
- Thermal Radiation and Cooling Technologies
- Gut microbiota and health
- Microscopic Colitis
- Radiation Detection and Scintillator Technologies
- Photonic and Optical Devices
- Superconductivity in MgB2 and Alloys
- Nuclear Physics and Applications
- Atomic and Subatomic Physics Research
- X-ray Diffraction in Crystallography
- Supramolecular Self-Assembly in Materials
- Crystallization and Solubility Studies
- Clostridium difficile and Clostridium perfringens research
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Calibration and Measurement Techniques
- Particle accelerators and beam dynamics
- Polydiacetylene-based materials and applications
- Surfactants and Colloidal Systems
- Lipid Membrane Structure and Behavior
- Microwave Engineering and Waveguides
Shiga University of Medical Science
2016-2025
Tokai University
2024
Nagahama City Hospital
2022-2024
The University of Tokyo
2013-2023
Nissan Chemical Corporation (Japan)
2009-2023
National Institute of Diabetes and Digestive and Kidney Diseases
2023
ProQuest (United States)
2023
Bunkyo University
2007-2021
Tokyo Metropolitan University
2021
National Institute of Advanced Industrial Science and Technology
2021
The mucosa-associated gut microbiota directly modulates epithelial and mucosal function. In this study, we investigated the microbial community in patients with inflammatory bowel disease (IBD), using endoscopic brush samples. A total of 174 mucus samples from 43 ulcerative colitis (UC), 26 Crohn’s (CD) 14 non-IBD controls were obtained by gentle brushing surfaces cytology brushes. microbiome was analyzed 16S rRNA gene sequencing. There no significant differences structure among different...
Curcumin is a hydrophobic polyphenol derived from turmeric, traditional Indian spice. exhibits various biological functions, but its clinical application limited due to poor absorbability after oral administration. A newly developed nanoparticle curcumin shows improved in vivo. In this study, we examined the effects of (named Theracurmin) on experimental colitis mice.BALB/c mice were fed with 3% dextran sulfate sodium (DSS) water. Mucosal cytokine expression and lymphocyte subpopulation...
Here we show that amides of bicyclic 7-azabicyclo[2.2.1]heptane are intrinsically nitrogen-pyramidal. Single-crystal X-ray diffraction structures some relevant amides, including the prototype N-benzoyl-7-azabicyclo[2.2.1]heptane, exhibited nitrogen-pyramidalization in solid state. We evaluated rotational barriers about amide bonds various N-benzoyl-7-azabicyclo[2.2.1]heptanes solution. The observed reduction as compared with those monocyclic pyrrolidine is consistent a nitrogen-pyramidal...
Astaxanthin is a xanthophyll carotenoid, which possesses strong scavenging effect on reactive oxygen species. In this study, we examined the of astaxanthin dextran sulfate sodium (DSS)-induced colitis in mice. Experimental was induced by oral administration 4% w/v DSS tap water C57BL/6J mixed with normal rodent diet (0.02 or 0.04%). significantly ameliorated DSS-induced body weight loss and reduced disease activity index. The ameliorating effects observed dose-dependent manner....
Although there are several reports of associations between body composition parameters and outcomes in patients with inflammatory bowel disease (IBD), it is not clear which muscle tissue and/or adipose most strongly affect outcomes. Therefore, this study sought to determine the such determined at level third lumbar vertebra (L3) on computed tomography (CT) images IBD patients.Subjects were who admitted our hospital underwent abdominal CT. The following assessed: skeletal index, psoas...
Although sarcoid-like reactions are uncommon in colorectal cancer, they can coexist with other cancers. We herein report a 50-year-old woman sigmoid adenocarcinoma and osseous that resembled metastases. Positron emission tomography-computed tomography revealed an uptake the iliac bone para-aortic lymph nodes. The depth of invasion indicates non-metastatic lesions. Bone node biopsies epithelioid non-caseating granulomas trabeculae, resulting final diagnosis pathological T2N2aM0, Stage IIIB....
Achievement of endoscopic healing (EH) is significant in the clinical practice inflammatory bowel disease as it correlated with improved prognosis. Existing biomarkers, including C-reactive protein (CRP), have relatively low accuracy for predicting EH, especially small intestinal lesions Crohn's (CD); thus, noninvasive and more accurate biomarkers are required. Leucine-rich alpha-2 glycoprotein (LRG), a 50-kD protein, produced under conditions has been reported to be useful assessing...
Small intestinal bacterial overgrowth (SIBO) is diagnosed by using quantitative culture of duodenal aspirates and/or a hydrogen breath test. However, few studies have analyzed microbiota in Japanese patients with SIBO.Twenty-four any abdominal symptoms and suspected SIBO were enrolled. Quantitative glucose test performed on the same day. was based count ≥ 103 CFU/mL or rise level 20 ppm. The composition 16S rRNA gene sequencing.Small 17 24 (71%). positive rates for 50% 62%, respectively....
To investigate interleukin (IL)-26 expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD) and function IL-26.Human colonic subepithelial myofibroblasts (SEMFs) were isolated from colon tissue surgically resected. The IL-26 protein its receptor complex was analyzed by immunohistochemistry. gene induced evaluated real-time polymerase chain reaction. Intracellular signaling pathways immunoblotting specific small interfering (si) RNA transfection.The mRNA...
Probiotic properties of Enterococcus strains have been reported previously. In this study, we investigated the effects (E.) durans TN-3 on development dextran sulfate sodium (DSS) colitis.BALB/c mice were fed with 4.0% DSS in normal chow. Administration (10mg/day) was initiated 7days before start feeding. Mucosal cytokine expression analyzed by real time-PCR and immunohistochemistry. The lymphocyte subpopulation flow cytometry. gut microbiota profile a terminal-restriction fragment length...
<b><i>Introduction:</i></b> Microbiomes play a vital role in the development and progression of cancer. The clinical status, including prognosis, genetic mutations, sensitivity to chemotherapy, differs depending on location colorectal cancer (CRC); however, association between gut microbiota CRC is not entirely understood. This study was conducted evaluate differences patients with according tumor. <b><i>Methods:</i></b> Fifty-six who underwent...
Background/Aims: Crosstalk between the gut microbiota and bile acid plays an important role in pathogenesis of gastrointestinal disorders. We investigated relationship microbial structure metabolism ileal mucosa Crohn’s disease (CD).Methods: Twelve non-CD controls 38 CD patients clinical remission were enrolled. Samples collected from distal ileum under balloon-assisted enteroscopy. Bile composition was analyzed by liquid chromatography-mass spectrometry. The 16S rRNA gene...
Interleukin (IL)-38 exerts an anti-inflammatory function by binding to several cytokine receptors, including the IL-36 receptor. In this study, we evaluated IL-38 expression in inflamed mucosa of patients with inflammatory bowel disease (IBD) and investigated its functions. mRNA endoscopic biopsy samples was using quantitative PCR. protein analyzed immunohistochemical technique. Dextran sulfate sodium-induced colitis induced C57BL/6 background IL-38KO mice. The were enhanced active...
Heating and then cooling down a dispersion of peptide amphiphile in water forms hierarchical fibril structures leading to supramolecular hydrogel. When the gel was physically broken apart by shaking, it transformed into sol state. After aging at room temperature for given time, returned state (re-gelation). To obtain better understanding such re-gelation processes, we have applied particle tracking obtained disrupting gel, as function time. The more heterogeneous micrometer scale than...
Background and aim Adherent-invasive E. coli (AIEC) has been identified as a pathobiont associated with Crohn’s disease (CD), that prefers to grow in inflammatory conditions. Although the colonization by AIEC is implicated progression of exacerbates inflammation murine colitis models, recognition response host immunity remains elusive. Methods Antibiotic treated female C57BL/6 mice were inoculated commensal LF82 strains. Luminal-IgA fractions prepared from feces their binding other strains...
Gut dysbiosis associated with intestinal inflammation is characterized by the blooming of particular bacteria such as adherent-invasive E. coli (AIEC). However, precise mechanisms which AIEC impact on colitis remain largely unknown. Here we show that antibiotic-induced worsened chemically-induced in IL-22-deficient mice, but not wild-type mice. The increase was expansion strains genetic and functional features AIEC. These isolates exhibited high ability to out compete related via colicins...
We demonstrate herein the variation in viscoelastic properties of supramolecular hydrogels (SMG) composed two amphiphiles, <italic>N</italic>-Palmitoyl-Gly-His (PalGH) and sodium palmitate (PalNa).
We are developing transition edge sensor with a superconducting high-Z metal bulk absorber for high energy resolution spectroscopy of hard X-ray and gamma-ray within 100 keV ~ 1 MeV. applied tantalum it has low heat capacity absorption efficiency to photons. As result an experiment using from <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">137</sup> Cs, that is better than Ge semiconductor detector was achieved at 662 keV. In addition, we...