A5037876490- Ubiquitin and proteasome pathways
- Histone Deacetylase Inhibitors Research
- Energy, Environment, Economic Growth
- Energy and Environment Impacts
- Protein Degradation and Inhibitors
- RNA Research and Splicing
- Sirtuins and Resveratrol in Medicine
- Anaerobic Digestion and Biogas Production
- Protein Tyrosine Phosphatases
- Migration and Labor Dynamics
- Mining and Resource Management
- Cancer Immunotherapy and Biomarkers
- Redox biology and oxidative stress
- Migration, Ethnicity, and Economy
- Cancer-related Molecular Pathways
- Economic Growth and Development
- Gastric Cancer Management and Outcomes
- Environmental Impact and Sustainability
- Inflammatory Biomarkers in Disease Prognosis
- Methane Hydrates and Related Phenomena
- Adenosine and Purinergic Signaling
- Heat shock proteins research
- Fiscal Policy and Economic Growth
- Microbial Community Ecology and Physiology
- Diaspora, migration, transnational identity
Shanghai Jiao Tong University
2020-2024
Shanghai Ninth People's Hospital
2020-2024
Nanjing Normal University
2023
Beijing Institute of Technology
2021
Institute of Process Engineering
2021
Purpose This study is dedicated to investigate why Mainland Chinese students pursuing higher education in Hong Kong are more likely return first-tier cities China rather than stay after graduation, despite Kong’s increasing efforts retain them as talent. By identifying the rationale that leads make such a choice, critical gap talent retention strategies for emerging hubs can thus be addressed. Design/methodology/approach Through semi-structured interviews among 20 have recently graduated...
The purpose of this study is to explore the prognostic value associating pre-treatment neutrophil-lymphocyte ratio (NLR) with circulating tumor cells counts (CTCs) in patients gastrointestinal cancer.We collected related data 72 gastric cancer (GC) and colorectal (CRC) who received different therapies from August 2016 October 2020, including age, gender, primary location, TNM stage, tumor-differentiation, NLR, CTCs, disease-free survival (DFS) overall (OS). We chose optimal cut-off NLR >3.21...
SUMOylation is an important post-translational modification that participates in a variety of cellular physiological and pathological processes eukaryotic cells. Sirt2, NAD+-dependent deacetylase, usually exerts tumor-suppressor function. However, the role cancer cells not fully known. In this study, we found can occur Sirt2 protein at both lysine 183 340 sites. did affect localization or stability but was involved P38-mTORC2-AKT signal transduction via direct deacetylation on new substrate...
Abstract MAPK/p38 is an important mammalian signaling cascade that responds to a variety of intracellular or extracellular stimuli, such as reactive oxygen species (ROS), and participates in numerous physiological pathological processes. However, the biological function p38 different tumors, even at stages same tumor, remains elusive. To further understand regulatory mechanism oxidative stress occurrence development gastric cancer, we report SUMOylation novel post-translational modification...
Lung cancer is one of the most threatening malignant tumors to human health. Epidermal growth factor receptor ( EGFR )‐targeted therapy a common and essential means for clinical treatment lung cancer. However, drug resistance has always affected therapeutic effect survival rate in non‐small cell NSCLC ). Tumor heterogeneity significant reason, yielding various mechanisms, such as ‐dependent or ‐independent extracellular signal‐regulated kinase 1 and/or 2 ERK1 /2) activation . To examine...
Androgen-regulated DNA damage response (DDR) is one of the essential mechanisms in prostate cancer (PCa), a hormone-sensitive disease. The heterogeneous nuclear ribonucleoprotein K (hnRNPK)-homology splicing regulatory protein known as far upstream element-binding 2 (KHSRP) an RNA-binding that can attach to AU-rich elements 3' untranslated region (3'-UTR) messenger RNAs (mRNAs) mediate mRNA decay and emerges critical regulator DDR preserve genome integrity. Nevertheless, how KHSRP responds...
Solar energy technology innovation plays a crucial role in achieving green and sustainable development low-carbon economy. The literature focuses on the economic environmental effects of solar but ignores investment multilateral banks (MDBs) technological innovation. Using panel data 37 countries, including OECD countries China, from 2006 to 2019, we adopt multi-period DID model empirically analyze impact MDBs results show that can significantly promote innovation, with conclusion still...
Abstract Background SUMOylation is an important post-translational modification and participates in a variety of cellular physiological pathological processes eukaryotic cells. Sirt2, as NAD + -dependent deacetylase, usually exerts tumor-suppressor function. However, its roles cancer cells have not been illustrated. Methods Ni 2+ -NTA, GST-pull down immunoprecipitation vitro vivo were used for the Sirt2-SUMOylation or P38-Acetylation assay. Immunofluorescence Nuclear/Cytosol Fractionation...