A5001496793- Estrogen and related hormone effects
- Reproductive biology and impacts on aquatic species
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Effects and risks of endocrine disrupting chemicals
- Multiple Myeloma Research and Treatments
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Plant Virus Research Studies
- Fungal Plant Pathogen Control
- Phytoestrogen effects and research
- Microtubule and mitosis dynamics
- Natural product bioactivities and synthesis
Institut de génétique et de développement de Rennes
2021-2025
Université de Rennes
2018-2025
Centre National de la Recherche Scientifique
2021-2025
Inserm
2018-2025
Institut de Recherche en Santé, Environnement et Travail
2014-2018
Abstract The fungal Bromodomain and Extra‐Terminal (BET) protein Bdf1 is a potential antifungal target against invasive infections. However, the need to selectively inhibit both bromodomains (BDs) over human orthologs lack of molecular tools assess on‐target efficacy hamper efforts develop BD inhibitors as therapeutics. This study reports phenyltriazine compound that inhibits BDs from pathogen Candida glabrata with selectivity orthologous BET Brd4. On‐target activity established by devising...
Comprehension of compound interactions in mixtures is increasing interest to scientists, especially from a perspective mixture risk assessment. However, most conducted studies have been dedicated the effects on gonads, while only few them were. interested central nervous system which known target for estrogenic compounds. In present study, estradiol (E2), natural estrogen, and genistein (GEN), phyto-estrogen, brain ER-regulated cyp19a1b gene radial glial cells were investigated alone...
Sister chromatid cohesion is a multi-step process implemented throughout the cell cycle to ensure correct transmission of chromosomes daughter cells. While establishment and mitotic dissolution have been extensively explored, regulation cohesin loading still poorly understood. Here, we report that methyltransferase NSD3 essential for sister before mitosis entry. interacts with loader complex kollerin (NIPBL/MAU2) promotes chromatin recruitment MAU2 at exit. We also show associates in early...
Abstract Small molecules that target one or both bromodomains (BDs) of human BET proteins are intensely studied as potential new therapeutics against cancer, diabetes and other diseases. The BDs the fungal protein Bdf1 essential for pathogen Candida albicans , suggesting inhibition a antifungal strategy. However, while inactivation is lethal, single BD only modestly affects viability, implying need to develop compounds selectively without inhibiting BDs. Here, we investigate in glabrata an...
Abstract Sister chromatid cohesion guarantees the correct transmission of chromosomes to daughter cells, and this multi-step process occurs throughout cell cycle. Loading core cohesin complex onto chromatin takes place during mitotic exit, establishment happens DNA replication, timely removal mitosis. While dissolution have already been explored, regulation loading is not as well understood. Here, we report that histone-lysine N-methyltransferase NSD3 an essential factor in sister...