A5006573755- Biocrusts and Microbial Ecology
- Fungal and yeast genetics research
- Endoplasmic Reticulum Stress and Disease
- Microbial Metabolic Engineering and Bioproduction
- Biochemical and Molecular Research
- Photosynthetic Processes and Mechanisms
- Enzyme Structure and Function
- Microtubule and mitosis dynamics
- Ecosystem dynamics and resilience
- RNA Research and Splicing
- Tardigrade Biology and Ecology
- Parkinson's Disease Mechanisms and Treatments
- Algal biology and biofuel production
- Reproductive Biology and Fertility
- Biofield Effects and Biophysics
- RNA and protein synthesis mechanisms
- Prion Diseases and Protein Misfolding
- Biofuel production and bioconversion
- Transgenic Plants and Applications
- Amyotrophic Lateral Sclerosis Research
- Genetic Neurodegenerative Diseases
- Cellular Mechanics and Interactions
Max Planck Institute of Molecular Cell Biology and Genetics
2012-2018
TU Dresden
2018
Martin Luther University Halle-Wittenberg
2014
Cells can enter into a dormant state when faced with unfavorable conditions. However, how cells and recover from this is still poorly understood. Here, we study dormancy in different eukaryotic organisms find it to be associated significant decrease the mobility of organelles foreign tracer particles. We show that reduced caused by an influx protons marked acidification cytoplasm, which leads widespread macromolecular assembly proteins triggers transition cytoplasm solid-like increased...
One of the key questions in biology is how metabolism a cell responds to changes environment. In budding yeast, starvation causes drop intracellular pH, but functional role this pH change not well understood. Here, we show that enzyme glutamine synthetase (Gln1) forms filaments at low and filament formation leads enzymatic inactivation. Filament by Gln1 highly cooperative process, strongly dependent on macromolecular crowding, involves back-to-back stacking cylindrical homo-decamers into...
How cells adapt to varying environmental conditions is largely unknown. Here, we show that, in budding yeast, the RNA-binding and stress granule protein Pub1 has an intrinsic property form condensates upon starvation or heat that condensate formation associated with cell-cycle arrest. Release from arrest coincides dissolution, which takes minutes (starvation) hours (heat shock). In vitro reconstitution reveals different dissolution rates of starvation- heat-induced are due their material...
Acute stress causes a rapid redistribution of protein quality control components and aggregation-prone proteins to diverse subcellular compartments. How these remarkable changes come about is not well understood. Using phenotypic reporter for synthetic yeast prion, we identified two protein-sorting factors the Hook family, termed Btn2 Cur1, as key regulators spatial in Saccharomyces cerevisiae. Cur1 are undetectable under normal growth conditions but accumulate stressed cells due increased...
SUMMARY One of the key questions in biology is how metabolism a cell responds to changes environment. In budding yeast, starvation causes drop intracellular pH, but functional role this pH change not well understood. Here, we show that enzyme glutamine synthetase (Gln1) forms filaments at low and filament formation leads inactivation. Filament by Gln1 highly cooperative process, strongly dependent on macromolecular crowding, involves back-to-back stacking cylindrical homo-decamers into...