A5038048177- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- 3D Printing in Biomedical Research
- Intensive Care Unit Cognitive Disorders
- Liver physiology and pathology
- Pancreatitis Pathology and Treatment
- Multiple Sclerosis Research Studies
- Folate and B Vitamins Research
- Liver Disease and Transplantation
- Immune cells in cancer
- Case Reports on Hematomas
- Prostate Cancer Treatment and Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Sphingolipid Metabolism and Signaling
- Inflammatory Myopathies and Dermatomyositis
- Peripheral Neuropathies and Disorders
- Olfactory and Sensory Function Studies
- Eicosanoids and Hypertension Pharmacology
- Cardiac tumors and thrombi
- Clinical Nutrition and Gastroenterology
- Muscle and Compartmental Disorders
- Erythrocyte Function and Pathophysiology
Jena University Hospital
2016-2024
Friedrich Schiller University Jena
2022
Some patients experience long-term sequelae after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, despite a present post-COVID condition, defined as "any symptom lasting longer than 12 weeks," only subset of search for medical help and therapy.We invited all adults positive real-time polymerase chain reaction (RT-PCR) SARS-CoV-2 between March 2020 September 2021 (n = 4091) in the city Jena to answer standardized questionnaire including demographic...
Abstract Liver dysfunction is an early event in sepsis-related multi-organ failure. We here report the establishment and characterization of a microfluidically supported vitro organoid model human liver sinusoid. The composed vascular hepatocyte cell layers integrating non-parenchymal cells closely reflecting tissue architecture enables physiological cross-communication bio-inspired fashion. Inflammation-associated was mimicked by stimulation with various agonists toll-like receptors....
Abstract Introduction Following SARS‐CoV‐2‐infection up to 21% of patients will develop post‐COVID‐syndrome. Autoantibodies (AAbs) targeting neuronal‐ß‐adrenergic and muscarinic receptors may provide crucial contributions the pathophysiology this condition. Immunoadsorption (IA) has been identified as an effective means removing AAbs resulted in clinical improvements other autoantibody‐associated diseases. Methods We determined AAb‐levels (anti‐ß1/ß2 anti‐M3/M4 receptor) 178 diagnosed with...
Glucocorticoids (GC) are potent anti-inflammatory agents, broadly used to treat acute and chronic inflammatory diseases, e.g., critically ill COVID-19 patients or with bowel diseases. GC not only limit inflammation but also promote its resolution although the underlying mechanisms obscure. Here, we reveal reciprocal regulation of 15-lipoxygenase (LOX) isoform expression in human monocyte/macrophage lineages by respective consequences for biosynthesis specialized proresolving mediators (SPM)...
Abstract Introduction Post-COVID syndrome is increasingly recognized as a new clinical entity after SARS-CoV-2 infection. Patients living in rural areas may have to travel long with subjectively great effort be examined using all necessary interdisciplinary tools. This problem could addressed mobile outpatient clinics. Methods In this prospective observational study, we investigated physical fitness, fatigue, depression, cognitive dysfunction, and dyspnea patients post-COVID clinic. Upon...
The molecular mechanisms of maladaptive response in liver tissue with respect to the acute and post-acute phase sepsis are not yet fully understood. Long-term survivors might develop hepatocellular/hepatobiliary injury fibrosis. Here, we demonstrate that acid sphingomyelinase, an important regulator hepatocyte apoptosis hepatic stellate cell (HSC) activation, is linked promotion dysfunction as well fibrogenesis long-term. In both phases, observed a beneficial effect partial genetic...
Persistent and new-onset symptoms after SARS-CoV-2 infection (so-called Long/Post-COVID syndrome) represent a major challenge for our healthcare system. However, there have been limited data on primary outpatient care planning, complicating patient flow management ultimately care. Assessing the reality of patients with Long/Post-COVID-symptoms, as well their difficulties desires in receiving medical care, is necessary first step toward improving
Disseminated intravascular coagulation (DIC) is a systemic disease characterized by simultaneous thrombosis, bleeding, and partially excessive fibrinolysis. Systemic shock, trauma, bacterial toxins, procoagulants-expressing solid hematologic malignancies are common causes of this life-threatening hemorrhagic complication often require treatment in intensive care units. We describe case an elderly man with recurrent severe bleeding events the cause DIC, including epistaxis, hemoptysis,...
Introduction Liver cirrhosis is a complex disease associated with an increased risk of malnutrition, particularly vitamins and minerals. Interestingly in contrast to these findings, patients often exhibit normal or even elevated serum levels vitamin B12. However, the extent which functional cobalamin deficiency exists despite adequate plasma individuals has not yet been sufficiently investigated. Therefore, aim present study was determine markers patients.
Background After acute infection with SARS-CoV-2, a significant proportion of patients suffer from post-COVID. Pathomechanisms underlying the development these sequalae are still poorly understood, several studies suggest an increased risk in comorbidities. Chronic liver disease may play relevant role, as frequent symptoms like fatigue can occur both, post-COVID and chronic disease. Therefore, aim our study was to evaluate frequency steatosis hepatis suffering syndrome
The prevalence of long-/post-COVID-associated chemosensory symptoms is reported in the literature to be significantly higher than clinical reality reflects.
Abstract Introduction Post-COVID syndrome is increasingly recognized as a new clinical entity after SARS-CoV-2 infection. Patients living in rural areas may have to travel long with subjectively great effort be examined using all necessary interdisciplinary tools. This problem could addressed mobile outpatient clinics. Methods In this prospective observational study, we investigated physical fitness, fatigue, depression, cognitive dysfunction and dyspnea patients post-COVID clinic. Upon...
Portal hypertension leads to pronounced venous collateralization and development of varices. Besides manifest liver cirrhosis, primarily left-sided portal is causal for the gastric We present a case 36-year-old female patient with splenomegaly, underlying primary myelofibrosis, detection somatic Janus-kinase-2 driver-mutation JAK2V617F. Following first upper gastrointestinal bleeding, isolated varices could be detected as result hypertension. Within few months, repeated life-threatening...