A5039277435- Multiple Sclerosis Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Reproductive System and Pregnancy
- Gut microbiota and health
- Optical Imaging and Spectroscopy Techniques
- Heart Rate Variability and Autonomic Control
- Systemic Lupus Erythematosus Research
- Construction Project Management and Performance
- Cardiovascular and exercise physiology
- Hemodynamic Monitoring and Therapy
- Clostridium difficile and Clostridium perfringens research
- Immune Response and Inflammation
- Sports Performance and Training
- Ultrasound and Hyperthermia Applications
- Estrogen and related hormone effects
- Cancer Research and Treatments
- Veterinary Oncology Research
- Asthma and respiratory diseases
- Pancreatic and Hepatic Oncology Research
- Mycobacterium research and diagnosis
- Polyomavirus and related diseases
- Liver Diseases and Immunity
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Data-Driven Disease Surveillance
Virginia–Maryland College of Veterinary Medicine
2017-2024
Virginia Tech
2017-2024
Biogen (United States)
2016-2023
Ashfield Healthcare
2020
E Ink (South Korea)
2020
Jacksonville College
2019
Mayo Clinic in Florida
2019
WinnMed
2019
John Snow (United States)
2004-2019
NYU Langone Health
2017
Systemic lupus erythematosus, characterized by persistent inflammation, is a complex autoimmune disorder with no known cure. Immunosuppressants used in treatment put patients at higher risk of infections. New knowledge disease modulators, such as symbiotic bacteria, can enable fine-tuning parts the immune system, rather than suppressing it altogether.
ABSTRACT Gut microbiota dysbiosis has been observed in a number of autoimmune diseases. However, the role gut systemic lupus erythematosus (SLE), prototypical disease characterized by persistent inflammation multiple organs body, remains elusive. Here we report dynamics murine model, NZB/W F1, as well intestinal small group SLE patients with active disease. The composition changed markedly before and after onset F1 mice, greater diversity increased representation several bacterial species...
To investigate the immune response to vaccinations in patients with relapsing forms of MS treated delayed-release dimethyl fumarate (DMF) vs nonpegylated interferon (IFN).In this open-label, multicenter study, received 3 vaccinations: (1) tetanus-diphtheria toxoid (Td) test T-cell-dependent recall response, (2) pneumococcal vaccine polyvalent T-cell-independent humoral and (3) meningococcal (groups A, C, W-135, Y) oligosaccharide CRM197 conjugate neoantigen response. Eligible were aged 18-55...
Limited data are available on the real-world effectiveness of newer oral disease-modifying therapies (DMTs) in multiple sclerosis. The purpose this study was to retrospectively compare dimethyl fumarate (DMF), fingolimod, teriflunomide, and injectable DMTs routine clinical practice based US claims data.Patients newly-initiating DMF, interferon beta (IFNβ), glatiramer acetate (GA), or fingolimod 2013 were identified Truven MarketScan Commercial Claims Databases (N = 6372). Relapse episodes a...
Significance Infants are born without an established gut microbiota, which develops rapidly after birth and is shaped by the maternal microbiota. However, how through shaping neonatal would affect establishment of a strong immune system in neonates remains unclear. Here, we show mechanistically microbiota regulates de novo production IgA.
Magnetic resonance imaging (MRI) is used pervasively in veterinary practice for the antemortem diagnosis of intracranial tumors. Here, we provide an illustrated summary published MRI features primary and secondary tumors dogs cats, following PRISMA scoping review guidelines. The PubMed Web Science databases were searched relevant records, input from stakeholders was solicited to select data extraction. Sixty-seven studies moderate low-level evidence quality describing pathologically...
Cerebrovascular autoregulation has been described with a phase lead of cerebral blood flow preceding changes in perfusion pressure (CPP), but there less focus on the effect CPP vascular resistance. We investigated these relations during spontaneous fluctuations (control) and repeated head-up tilt.Eight healthy adults were studied supine rest tilt 10-second supine, 10 seconds at 45 degrees for total 12 cycles. Cerebral was estimated from mean velocity (MFV) by transcranial Doppler ultrasound,...
Autoimmune diseases, such as systemic lupus erythematosus, are characterized by excessive inflammation in response to self-antigens. Loss of appropriate immunoregulatory mechanisms contribute disease exacerbation. We previously showed the suppressive effect vancomycin treatment during "active-disease" stage lupus. In this study, we sought understand same given before onset. To develop a model which test regulatory role gut microbiota modifying autoimmunity, treated lupus-prone mice with...
Abstract Meningiomas are the most common feline primary brain tumours, and calvarial hyperostosis (CH) is frequently documented in association with this neoplastic entity. The clinical significance of mechanisms driving formation CH cats meningiomas poorly understood, although tumour invasion into skull production cytokines enzymes have been implicated as causes humans. This retrospective study investigated relationships between signalment, MRI or CT imaging features, histopathologic...
Ventilation and locomotion coupling (entrainment) has been observed described in rowers during incremental exercise protocols but not simulated race conditions. The purpose of this descriptive study was to examine ventilation entrainment on a breath-by-breath stroke-by-stroke basis varsity male maximal 2,000-m ergometer test. Eight eleven entrained at integral multiples stroke rate (1:1, 2:1, or 3:1) for least 120 consecutive seconds, with 2:1 pattern being most common. In all 2:1-entrained...
Abstract The course and severity of lupus in spontaneous murine models varies among laboratories, which may be due to variations diet, housing and/or local environmental conditions. In this study, we investigated the influence common rodent diets while keeping other factors constant. Female lupus-prone MRL/lpr (MRL/MpJ-Faslpr/J) mice were subjected same conditions given one three diets: Teklad 7013 containing isoflavone-rich soy alfalfa, Harlan 2018 soy-based diet or Research Diets Inc....
Objective To determine clinical signs, radiographic findings, results of surgical management, and potential causes aseptic loosening the femoral implant (ALFI) in dogs that have undergone cemented total hip arthroplasty (THA). Design Retrospective study. Animals 11 cases ALFI 10 dogs. Procedure Medical records all undergoing THA revision surgery were reviewed. Only with included. The prosthesis cement removed by creating a longitudinal osteotomy cranial cortex. Postoperative radiographs...
EDWARDS, M. R., D. H. MARTIN, and R. L. HUGHSON. Cerebral hemodynamics resistance exercise. Med. Sci. Sports Exerc., Vol. 34, No. 7, pp. 1207–1211, 2002. Purpose Repetitive exercise with large muscle mass causes rapid fluctuations in mean arterial blood pressure (MAP). We sought to determine the effect of these on cerebrovasculature response determined by flow velocity (Vmean) middle cerebral artery. Methods Nine subjects performed 10-repetition maximum leg press MAP was estimated finger...
Transfer function analysis of the arterial blood pressure (BP)-mean flow velocity (MFV) relationship describes an aspect cerebrovascular autoregulation. We hypothesized that transfer relating BP to resistance (CVRi) would be sensitive low-frequency changes in autoregulation induced by head-up tilt (HUT) and altered Pco 2 . Nine subjects were studied supine HUT positions with end-tidal (Pet CO ) kept constant at normal levels: +5 −5 mmHg. The BP-MFV had low coherence frequencies, there...
Beat-by-beat estimates of total peripheral resistance (TPR) can be obtained from continuous measurements cardiac output by using Doppler ultrasound and noninvasive mean arterial blood pressure (MAP). We employed transfer function analysis to study the heart rate (HR) vascular response spontaneous changes in relationships systolic (SBP) HR (SBP-->HR), MAP cerebrovascular index (CVRi) (MAP-->TPR MAP-->CVRi), as well stroke volume (SV) TPR nine healthy subjects supine 45 degrees head-up tilt...
The new two-breath CO(2) method was employed to test the hypotheses that small alterations in arterial P(CO(2)) had an impact on magnitude and dynamic response time of effect cerebrovascular resistance (CVRi) autoregulatory fluctuations pressure. During a 10-min protocol, eight subjects inspired two breaths from bag with elevated P(CO(2)), four different times, while end-tidal maintained at three levels: hypocapnia (LoCO(2), 8 mmHg below resting values), normocapnia, hypercapnia (HiCO(2),...
<h3>ABSTRACT</h3> Master health facility lists (MHFLs) are gaining attention as a standards-based means to uniquely identify facilities and link facility-level data. The ability reliably communicate information about specific can support an array of system functions, such routine reporting emergency response operations. MHFLs the alignment donor-supported systems with county-owned systems. Recent World Health Organization draft guidance promotes utility outlines process for list development...
Pancreatic cancer is a malignant disease associated with poor survival and nearly 80% present unresectable tumors. Treatments such as chemotherapy radiation therapy have shown overall improved benefits, albeit limited. Histotripsy noninvasive, non-ionizing, non-thermal focused ultrasound ablation modality that has efficacy in treating hepatic tumors other malignancies. In this novel study, we investigate histotripsy for noninvasive pancreas pig model. two studies, was applied to the healthy...
17α-Ethinyl estradiol (EE), a synthetic analog of natural estrogen 17β-estradiol (E2), is extensively used in hormonal contraceptives and replacement therapy, it has also been found sewage effluents. Given that E2 well-known immunomodulator, surprisingly there only limited information on the cellular molecular immunologic consequences exposure to EE. To address this fundamental gap, we directly compared effects EE with splenic leukocytes New Zealand Black × White F1 progeny (NZB/WF1) mice...