A5069268875- Infection Control and Ventilation
- COVID-19 epidemiological studies
- Influenza Virus Research Studies
- Respiratory viral infections research
- Air Quality and Health Impacts
- Bacteriophages and microbial interactions
- Diet, Metabolism, and Disease
- Atmospheric chemistry and aerosols
- Plant Virus Research Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Viral Infections and Outbreaks Research
- SARS-CoV-2 detection and testing
- Climate Change and Health Impacts
- Diet and metabolism studies
- COVID-19 impact on air quality
- Air Quality Monitoring and Forecasting
- Antibiotic Use and Resistance
- Inflammatory Bowel Disease
- Indoor Air Quality and Microbial Exposure
- Antibiotic Resistance in Bacteria
- Viral gastroenteritis research and epidemiology
- Plant and Fungal Interactions Research
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Microscopic Colitis
Quality Research
2025
Michigan State University
2023-2024
Virginia Tech
2017-2022
Systemic lupus erythematosus, characterized by persistent inflammation, is a complex autoimmune disorder with no known cure. Immunosuppressants used in treatment put patients at higher risk of infections. New knowledge disease modulators, such as symbiotic bacteria, can enable fine-tuning parts the immune system, rather than suppressing it altogether.
The transmission of some infectious diseases requires that pathogens can survive (i.e., remain infectious) in the environment, outside host. Relative humidity (RH) is known to affect survival microorganisms environment; however, mechanism underlying relationship has not been explained, particularly for viruses. We investigated effects RH on viability bacteria and viruses both suspended aerosols stationary droplets using traditional culture-based approaches. Results showed generally decreased...
Infectious diseases caused by enveloped viruses, such as influenza, severe acute respiratory syndrome (SARS), and Middle East (MERS), cause thousands of deaths billions dollars economic losses per year. Studies have found a relationship among temperature, humidity, influenza virus incidence, transmission, or survival; however, there are contradictory claims about whether absolute humidity (AH) relative (RH) is most important in mediating infectivity. Using the bacteriophage Phi6, which has...
Pandemic and seasonal influenza viruses can be transmitted through aerosols droplets, in which must remain stable infectious across a wide range of environmental conditions. Using humidity-controlled chambers, we studied the impact relative humidity on stability 2009 pandemic A(H1N1) virus suspended stationary droplets. Contrary to prevailing paradigm that modulates respiratory aerosols, found supplemented with material from apical surface differentiated primary human airway epithelial cells...
Abstract Background During a period of rapid growth in our understanding the microbiology built environment recent years, majority research has focused on bacteria and fungi. Viruses, while probably as numerous, have received less attention. In response, Alfred P. Sloan Foundation supported workshop entitled “Viruses Built Environment (VIBE),” at which experts environmental engineering, microbiology, epidemiology, infection prevention, fluid dynamics, occupational health, metagenomics,...
Significance Ambient humidity can influence the survival of pathogens in respiratory aerosols and droplets, although mechanism optimum level for public health remain unclear. Here, we present evidence a humidity-dependent, semisolid state droplets relevant to pathogen survival. These observations indicate that may protect from inactivation by hindering disinfection reactions at intermediate-to-low levels. The formation was dependent on composition aerosols, which suggests destruction will...
The survival of viruses in droplets is known to depend on droplets' chemical composition, which may vary respiratory fluid between individuals and over the course disease. This relationship also important for understanding persistence generated from wastewater, freshwater, seawater. We investigated effects salt (0, 1, 35 g/L), protein 100, 1000 μg/mL), surfactant 10 droplet pH (4.0, 7.0, 10.0) viability 1-μL pipetted onto polystyrene surfaces exposed 20%, 50%, 80% relative humidity (RH)...
Recent studies have shown that Ebola virus can persist in wastewater. We evaluated the potential for surrogates to be aerosolized from three types of wastewater systems: toilets, a lab-scale model an aeration basin, and converging sewer pipes. measured aerosol size distribution generated by each system, spiked (MS2 Phi6) into determined emission rate viruses air. The number aerosols released ranged 105 107 per flush toilets or minute models, total volume these systems was ∼10-9 10-7 mL all...
Highly transmissible influenza viruses (IV) must remain stable and infectious under a wide range of environmental conditions following release from the respiratory tract into air. Understanding how expelled IV persist in environment is critical to limiting spread these viruses. Little known about stability different aerosols impacted by exposure stressors, such as relative humidity (RH). Given that not all are equally capable efficient airborne transmission people, we anticipated would...
Deterministic models have been developed for the predictions of deposited dose to respiratory tract from inhalation airborne materials. The complexity lung geometry, ventilation mechanics, and transport processes required model assumptions simplifications. Model validation is an integral part development process before can be applied specific scenarios interest. While several efforts reported in literature regional deposition tract, there a desire refine enhance power smaller regions such as...
Inhalation of viable airborne pathogens often leads to respiratory infections. Among the different factors that affect survival pathogens, specific aerosol composition, such as secondary organic (SOA), may impact severity infection by stimulating host cell apoptotic responses. Here, we studied in vitro effects SOA (biogenic and anthropogenic) on human influenza A virus (H1N1). Viral gene copies bronchial epithelial line (BEAS-2B) fetal lung fibroflast (MRC-5) treated with were measured be...
Quantifying the dose and distribution of tobacco smoke in respiratory system is critical for understanding its toxicity, addiction potential, health impacts. Epidemiologic studies indicate that incidence lung tumors varies across different regions, suggesting there may be a heterogeneous deposition particles leading to greater risks specific regions. Despite this, few have examined lobar spatial inhaled from smoke. This gap knowledge, coupled with growing popularity little cigars among...