A5055326345- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Genetic Neurodegenerative Diseases
- Legionella and Acanthamoeba research
- Migraine and Headache Studies
- Liver physiology and pathology
- Indoor Air Quality and Microbial Exposure
- Cancer Cells and Metastasis
- Water Treatment and Disinfection
- Infection Control and Ventilation
- COVID-19 and healthcare impacts
- Chemical Reactions and Isotopes
- Olfactory and Sensory Function Studies
- Hedgehog Signaling Pathway Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Protein Degradation and Inhibitors
- Antifungal resistance and susceptibility
- Coordination Chemistry and Organometallics
- Phagocytosis and Immune Regulation
- Cardiomyopathy and Myosin Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Multiple Myeloma Research and Treatments
- Biochemical effects in animals
- Ubiquitin and proteasome pathways
- Fecal contamination and water quality
University of Bari Aldo Moro
2019-2024
Legionella is the causative agent of Legionnaires' disease, a flu-like illness normally acquired following inhalation or aspiration contaminated water aerosols. Our recent studies revealed that climatic parameters can increase number reported cases community-acquired disease. Here, we evaluated presence in networks and distribution disease associated with touristic-recreational facilities Apulia region (southern Italy) during period 2001-2017 using geostatistical analyses. Geostatistical...
A Coronavirus disease (COVID-19), caused by a new virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spreads via direct contact through droplets produced infected individuals. The transmission of this can also occur indirect if objects and surfaces are contaminated secretions from individuals with COVID-19 or asymptomatic carriers. Environmental contamination SARS-CoV-2 is high in hospital settings; on the contrary, surface non-healthcare settings still poorly...
Since the last decade, attention towards occurrence of fungi in potable water has increased. Commensal and saprophytic microorganisms widely distributed nature are also responsible for causing public health problems. Fungi can contaminate hospital environments, surviving proliferating moist unsterile conditions. According to Italian regulations, absence is not a mandatory parameter define water, as threshold value fungal been defined. This study evaluated distribution systems hospitals. The...
Background: The nondystrophic myotonias are rare muscle hyperexcitability disorders caused by gain-of-function mutations in the SCN4A gene or loss-of-function CLCN1 gene. Clinically, they characterized myotonia, defined as delayed relaxation after voluntary contraction, which leads to symptoms of stiffness, pain, fatigue, and weakness. Diagnosis is based on history examination findings, presence electrical myotonia electromyography, genetic confirmation. Methods: Next-generation sequencing...
Several commercially available and newly synthesized riluzole analogs were evaluated in vitro as voltage-gated skeletal muscle sodium-channel blockers. Data obtained from the patch-clamp technique demonstrated that potency is well correlated with lipophilicity introduction of a protonatable amino function benzothiazole 2-position enhances use-dependent behavior. The most interesting compound, 2-piperazine analog (14), although slightly less potent than parent compound assay an model...
Legionellosis is a severe pneumonia caused by the inhalation of aerosols containing Legionella, Gram-negative bacteria present in water systems touristic-recreational facilities. The purpose this study was to develop scoring tool predict risk both environmental contamination and Legionnaires' disease cases such facilities Apulia region southern Italy. We analyzed 47 structural management parameters/risk factors related buildings, systems, air conditioning at A Poisson regression model used...
Myotonia congenita (MC) is an inherited rare disease characterized by impaired muscle relaxation after contraction, resulting in stiffness. It caused loss-of-function mutations the skeletal chloride channel ClC-1, important for stabilization of resting membrane potential and repolarization phase action potentials. Thanks to vitro functional studies, molecular mechanisms which ClC-1 alter ion influx into cell have been part clarified, classifying them “gating-defective” or...