A5020987276- Cardiovascular Health and Risk Factors
- Dementia and Cognitive Impairment Research
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- Technology Use by Older Adults
- Nutritional Studies and Diet
- Cardiovascular Disease and Adiposity
- Obesity, Physical Activity, Diet
- Health disparities and outcomes
- Digital Mental Health Interventions
- Mobile Health and mHealth Applications
- Blood Pressure and Hypertension Studies
- Cognitive Functions and Memory
- Attention Deficit Hyperactivity Disorder
- Cardiovascular Health and Disease Prevention
- Genetic Associations and Epidemiology
- Sleep and related disorders
- Physical Activity and Health
- Diet and metabolism studies
- Mechanical Circulatory Support Devices
- Healthcare Systems and Public Health
- Sleep and Work-Related Fatigue
- Adipose Tissue and Metabolism
- Nosocomial Infections in ICU
- Cognitive Abilities and Testing
Tulane University
2021-2024
Rowan University
2022
Louisiana State University
2022
Emory University
2022
Boston University
2022
Pennington Biomedical Research Center
2022
Louisiana State University Health Sciences Center New Orleans
2022
Methodist Hospital
2020
Harvard University
2019
Worldwide, there are nearly 10 million new cases of dementia annually, which Alzheimer's disease (AD) is the most common. New measures needed to improve diagnosis individuals with cognitive impairment due various etiologies. Here, we report a deep learning framework that accomplishes multiple diagnostic steps in successive fashion identify persons normal cognition (NC), mild (MCI), AD, and non-AD dementias (nADD). We demonstrate range models capable accepting flexible combinations routinely...
Abstract INTRODUCTION We examined for associations between potentially modifiable risk factors across the adult life course and incident dementia. METHODS Participants from Framingham Heart Study were included ( n = 4015). Potential education, alcohol intake, smoking, body mass index (BMI), physical activity, social network, diabetes, hypertension. Cox models used to examine each factor dementia, stratified by early (33–44 years), midlife (45–65 late (66–80 years). RESULTS Increased dementia...
Introduction Advances in digital technologies for health research enable opportunities phenotyping of individuals and clinical settings. Beyond providing advanced data analytics with science machine learning approaches, offer solutions to several the existing barriers practice that have resulted biased samples. Methods A participant-driven, precision brain monitoring platform has been introduced two longitudinal cohort studies, Boston University Alzheimer's Disease Research Center (BU ADRC)...
Background Smartphone‐based cognitive assessments have emerged as promising tools, bridging gaps in accessibility and reducing bias Alzheimer disease related dementia research. However, their congruence with traditional neuropsychological tests usefulness diverse cohorts remain underexplored. Methods Results A total of 406 FHS (Framingham Heart Study) 59 BHS (Bogalusa participants digital using the Defense Automated Neurocognitive Assessment (DANA) smartphone protocol were included....
Although the growth of digital tools for cognitive health assessment, there's a lack known reference values and clinical implications these methods. This study aims to establish neuropsychological measures obtained through smartphone-based assessment application, Defense Automated Neurocognitive Assessment (DANA), identify risk factors associated with measures. The sample included 932 cognitively intact participants from Framingham Heart Study, who completed at least one DANA task....
Carotid intima-media thickness (c-IMT) is a measurement of atherosclerosis, progressive disease that develops as early childhood and has been linked with cognitive impairment dementia in the elderly. However, relationship between c-IMT midlife function race social disparities this remain unclear. We examined association among Black White participants from semirural community-based cohort Bogalusa, Louisiana.In cross-sectional analysis Bogalusa Heart Study, linear regression models were used...
Genetic information may help to identify individuals at increased risk for hypertension in early life, prior the manifestation of elevated blood pressure (BP) values. We examined 369 Black and 832 White Bogalusa Heart Study (BHS) participants recruited childhood followed approximately 37 years. The multi-ancestry genome-wide polygenic scores (PRSs) systolic BP (SBP), diastolic (DBP), were tested an association with incident stage 2 using Cox proportional hazards models. Race-stratified...
Background Smartphone‐based digital technology is increasingly being recognized as a cost‐effective, scalable, and noninvasive method of collecting longitudinal cognitive behavioral data. Accordingly, state‐of‐the‐art 3‐year project focused on multimodal data for early detection impairment was developed. Methods Results A smartphone application collected 2 modalities data, voice screen‐based behaviors, from the FHS (Framingham Heart Study) multigenerational Generation (Gen 2) 3 3) cohorts....
<sec> <title>BACKGROUND</title> Physical activity has emerged as a modifiable behavioral factor to improve cognitive function. However, research into the adherence remote monitoring of physical in older adults remains limited. </sec> <title>OBJECTIVE</title> This study aimed assess within pilot cohort from objective user data, providing insights for scalability such approaches larger, more comprehensive future studies. <title>METHODS</title> included 22 participants Boston University...
<sec> <title>BACKGROUND</title> Although digital technology represents a growing field aiming to revolutionize early Alzheimer disease risk prediction and monitoring, the perspectives of older adults on an integrated brain health platform have not been investigated. </sec> <title>OBJECTIVE</title> This study aims understand by conducting semistructured interviews analyzing their transcriptions natural language processing. <title>METHODS</title> The included 28 participants from Boston...
Physical activity has emerged as a modifiable behavioral factor to improve cognitive function. However, research on adherence remote monitoring of physical in older adults is limited.
Background Although digital technology represents a growing field aiming to revolutionize early Alzheimer disease risk prediction and monitoring, the perspectives of older adults on an integrated brain health platform have not been investigated. Objective This study aims understand by conducting semistructured interviews analyzing their transcriptions natural language processing. Methods The included 28 participants from Boston University Alzheimer’s Disease Research Center, all whom engaged...
Background: Early-onset hypertension is linked to higher risk of hypertensive organ damage compared late-onset hypertension. Insulin resistance has been shown be associated with greater Greater triglyceride-to-high density lipoprotein cholesterol ratio (TG/HDL-C), a surrogate marker insulin resistance, However, whether elevated long-term TG/HDL-C variability from childhood early-onset unclear. Methods: We studied 1271 participants the Bogalusa Heart Study (age at enrollment: 9.9 ± 4.0 years,...
Background: Early-onset hypertension is associated with greater risk of cardiovascular mortality and organ damage, compared to late-onset hypertension. Non-high-density lipoprotein cholesterol (non-HDL-C) known better predict future event risk, low-density cholesterol. Whether higher long-term non-HDL-C variability from childhood early-onset unclear. Methods: We included 1271 participants the Bogalusa Heart Study (age at enrollment: 9.9 ± 4.0 years, follow-up: 38.3 3.8 age last exam: 48.2...
Abstract Background Repeated self‐administered mobile‐based cognitive assessments are increasingly being utilized to identify preclinical decline. Repetition of tests during a short time interval often leads improved performance (i.e., practice effects) due familiarity with test structure. Therefore, test‐specific effects may delay the detection subtle Alternatively, lack effect indicate decline in function. This study investigated whether were present on three digital repeated over 3‐month...
Abstract Background Sleep disorders as a contributing factor to cognitive impairment have spurred growing interest. The advent of digital technology facilitates the collection comprehensive sleep measures in home setting. objective this study is examine association between and Montreal Cognitive Assessment (MoCA). Method This included participants from Boston University Alzheimer’s Disease Research Center (BU ADRC) Clinical Core, longitudinal aging which includes Uniform Dataset (UDS) other...
Abstract Background With the advent of monoclonal antibody therapy to treat mild cognitive impairment and dementia due Alzheimer’s disease (AD) there is a need develop tests screen for neurocognitive difficulty that are reliable easily deployed. Method The Rowan Digital Cancellation Tests (RDCT) comprised three administered using an iPad Pro. Each test was preceded by practice trial. During trials buzzer sounded when commission errors were made. For each test, participants worked 180 sec....
Abstract Background A typical paper/pencil neuropsychological evaluation to assess for mild cognitive impairment (MCI) and dementia is lengthy. There a need brief, digitally administered/scored protocol that can differentiate patients who are cognitively normal versus MCI dementia. This particularly acute with the advent of disease‐modifying medications treat early Alzheimer’s disease (AD). Method The Digital Assessment Cognition (DAC) assesses memory 6‐word Philadelphia (repeatable) Verbal...
Introduction: Obesity in midlife is associated with an increased risk of cognitive decline. It remains unclear if there a difference function between individuals obesity and metabolic dysfunction (metabolically abnormal - MAO) versus those metabolically healthy (MHO). We assessed the relationship MHO (vs mid-life among Black White Bogalusa Heart Study. Methods: The Study longitudinal cohort exploring natural history cardiovascular disease Bogalusa, Louisiana. This cross-sectional analysis...
Background: Despite the growing interest in role of isolated left ventricular (LV) diastolic dysfunction cardiac remodeling, little is known about its association with cognitive performance midlife, prior to onset dementia. Hypothesis: We hypothesized that LV and remodeling will be associated middle-aged adults. These associations might differ by sex race. Aim: To investigate impact atrial (LA) size, mass, volume, systolic function on cognition Black White, men women from a rural,...
Background: Exposure to elevated plasma non-high density lipoprotein cholesterol (non-HDL-C) levels during adulthood has been associated with higher risk of cardiovascular events. However, whether long term non-HDL-C variability from childhood impacts midlife cognitive function (CF) is unclear. Hypothesis: We hypothesized that long-term would be worse CF measures. Aim: aimed identify the effect lipid on CF. Methods: studied 1,249 participants Bogalusa Heart Study (age at baseline: mean 9.5...