A5015583181- Hemiptera Insect Studies
- Genomics and Phylogenetic Studies
- Plant and Fungal Interactions Research
- Botany and Geology in Latin America and Caribbean
- Biomedical Text Mining and Ontologies
- Collembola Taxonomy and Ecology Studies
- Phytoplasmas and Hemiptera pathogens
- Research on scale insects
- Insect-Plant Interactions and Control
- Topic Modeling
- Computational Drug Discovery Methods
- Species Distribution and Climate Change
- Insect Resistance and Genetics
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Advanced Graph Neural Networks
- RNA and protein synthesis mechanisms
- Kruppel-like factors research
- Tuberculosis Research and Epidemiology
- Pituitary Gland Disorders and Treatments
- Advanced Vision and Imaging
- Nutritional Studies and Diet
- Visual Attention and Saliency Detection
- Nutrition, Genetics, and Disease
- Plant Virus Research Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Peking University
2019-2025
Xinzhou Teachers University
2019-2024
Shanxi Agricultural University
2017-2018
Nanjing University
2018
Abstract N4-acetylcytidine (ac4C) is a highly conserved RNA modification and the first acetylation event described in mRNA. ac4C mRNA has been demonstrated to be involved regulation of stability, processing translation, but exact means by which works remain unclear. In addition, widely distributed within human transcriptome at physiologically relevant levels so far only small fraction modified sequences have detected experiments. this study, we developed predictor sites named PACES help...
The cotton mealybug, Phenacoccus solenopsis Tinsley (Hemiptera: Pseudococcidae), is a serious invasive species that significantly damages plants of approximately 60 families around the world. It originally from North America and has also been introduced to other continents. Our goals were create current future potential global distribution map for this pest under climate change with MaxEnt software. We tested hypothesis niche conservatism P. by comparing its native in niches on continents...
N6-methyladenosine (m6A) methylation has emerged as a prevalent RNA modification that extensively impacts various physiological and pathological processes via post-transcriptional readout effects in mammals. High-throughput methylome profiling outlined the landscape of m6A sites, but their downstream readouts require comprehensive investigation. To this end, we systematically assessed on mRNA half-life, translation efficiency, alternative splicing across five cell lines (A549, HEK293T,...
Background Measurement-based care improves patient outcomes by using standardized scales, but its widespread adoption is hindered the lack of accessible and structured knowledge, particularly in unstructured Chinese medical literature. Extracting scale-related knowledge entities from these texts challenging due to limited annotated data. While large language models (LLMs) show promise named entity recognition (NER), specialized prompting strategies are needed accurately recognize entities,...
Cycads are an ancient group of gymnosperms that popular as landscaping plants, though nearly all them threatened or endangered in the wild. The cycad aulacaspis scale (CAS), Aulacaspis yasumatsui Takagi (Hemiptera: Diaspididae), has become one most serious pests cycads recent years; however, potential distribution range and management approach for this pest unclear. A risk map was created based on occurrence data under different climatic conditions topology factors study. Furthermore, future...
Pentatoma rufipes (Linnaeus, 1758) is an important agroforestry pest widely distributed in the Palaearctic region. In this study, we sequence and annotate complete mitochondrial genome of P. reconstruct phylogenetic trees for Pentatomoidea using existing data eight families published National Center Biotechnology Information database. The mitogenome 15,887-bp-long, comprising 13 protein-coding genes, 22 transfer RNA two ribosomal a control region, with A+T content 77.7%. structure, gene...
Species of genus Aelia are important pests wheat crops in arid areas. In this study, the mitogenomes A. sibirica and fieberi were sequenced using high-throughput sequencing technology. The mitochondrial genome characteristics both species compared analyzed, phylogenetic relationships Pentatomidae constructed based on protein-coding genes. addition, taxonomic status was confirmed. results showed that total length mitogenome sequences 15,372 bp 15,450 bp, respectively, including 13 genes, 22...
The family Pentatomidae, the largest within superfamily Pentatomoidae, comprises about 5,000 species; many of which are economically important pests. Although phylogeny Pentatomidae species has been studied using various molecular markers, their phylogenetic relationships remain controversial. Recently, mitochondrial genomes (mitogenomes) have extensively employed to examine phylogenetics and evolution different insects, in this study, we sequenced complete/near-complete from five shield bug...
Abstract Objective Pituitary adenomas are the most common type of pituitary disorders, which usually occur in young adults and often affect patient’s physical development, labor capacity fertility. Clinical free texts noted electronic medical records (EMRs) patients contain abundant diagnosis treatment information. However, this information has not been well utilized because challenge to extract from unstructured clinical texts. This study aims enable machines intelligently process...
The complete mitochondrial genome of Eurydema maracandica was sequenced and 15,391 bp long with 76.82% A + T. There were 37 typical genes including 13 protein-coding genes/PCGs, 22 transfer RNA/tRNAs, 2 ribosomal RNA/rRNAs. 690 D-loop region located between 12S rRNA trnI-Ile. All PCGs started ATN codons, except COI, ATP8, ND1, ended TAA, COII, ND5. Phylogenetic analyses indicated highly supported monophyly for each family, Pentatomidae species formed a solid monophyletic group. gebleri...
Background The global pandemics of severe acute respiratory syndrome, Middle East and COVID-19 have caused unprecedented crises for public health. Coronaviruses are constantly evolving, it is unknown which new coronavirus will emerge when the next sweep across world. Knowledge graphs expected to help discover pathogenicity transmission mechanism viruses. Objective aim this study was potential targets candidate drugs repurpose coronaviruses through a knowledge graph–based approach. Methods We...
Here, we determined the complete mitogenome of Picromerus griseus, first for subfamily Asopinae. This mitochondrial genome contains 16,338 bp, with an A + T content 71.69%, and 37 typical genes (13 protein-coding genes, 22 transfer RNA two ribosomal a control region). The size, gene arrangement, content, codon usage secondary structures P. griseus were similar to those other sequenced pentatomoids. Bayesian analyses performed using mitogenomes its relatives, including 14 taxa, confirmed...
Mitochondrial genomes (mitogenomes) are widely used in research studies on phylogenetic relationships and evolutionary history. Here, we sequenced analyzed the mitogenome of scentless plant bug
Hygia Uhler, 1861 is the largest genus in bug family Coreidae. Even though many species of this are economically important, complete mitogenomes have not yet been reported. Therefore, present study, three species, H.lativentris (Motschulsky, 1866), H.bidentata Ren, 1987, and H.opaca (Uhler, 1860), sequenced characterized, submitted a phylogenetic analysis The results show that highly conserved, typically with 37 genes plus its control region. lengths 16,313 bp, 17,023 17,022 respectively....
The phenotype, as a significant identification character for the bug species Eurydema Laporte, 1833, possesses many variation patterns, making this difficult to determine. In context, DNA barcoding provides an efficient method identification. our study, we used distance-based and tree-based methods assess effectiveness of COI gene additional taxonomic method. We examined sequences 203 specimens collected in China. Intra- interspecific genetic distances were calculated, phylogenetic tree was...
<sec> <title>BACKGROUND</title> Measurement-based care improves patient outcomes by using standardized scales, but its widespread adoption is hindered the lack of accessible and structured knowledge, particularly in unstructured Chinese medical literature. Extracting scale-related knowledge entities from these texts challenging due to limited annotated data. While large language models (LLMs) show promise named entity recognition (NER), specialized prompting strategies are needed accurately...
Objective: Faced with the challenges of differential diagnosis caused by complex clinical manifestations and high pathological heterogeneity pituitary adenomas, this study aims to construct a high-quality annotated corpus characterize adenomas in notes containing rich treatment information. Methods: A dataset from neurosurgery center tertiary first-class hospital China was retrospectively collected. semi-automatic construction framework designed. total 2000 documents 9430 sentences 524,232...
Dimorphopterus japonicus is a kind of pest which seriously harms sorghum and millet. In this study, we sequenced the mitochondrial whole genome D. (Hidaka, 1959), characterized analyzed mitogenome. The length 15,473 bp, it exhibits typical high A + T content (77.6%). mitogenomic structure highly conservative there are no gene rearrangements. evolutionary rates PCGs in order atp8 > nad3 nad6 nad2 nad5 atp6 nad4 nad4L cox2 nad1 cytb cox3 cox1. By using Bayesian inference maximum likelihood...
BACKGROUND: Our previous single-cell RNA sequencing study in the adult human heart revealed that cardiomyocytes from both atrium and ventricle display high activities of Krüppel-like factor 2 (KLF2) regulons. However, role transcription KLF2 cardiomyocyte biology remains largely unexplored. METHODS AND RESULTS: We employed transverse aortic constriction surgery male C57BL/6J mice to develop an vivo model cardiac hypertrophy, generated different vitro hypertrophy models neonatal rat...
The complete mitogenome of Chorosoma macilentum Stål, 1858 was obtained using a next-generation sequencing approach, which is the first report in genus Chorosoma. genome 16,330 bp long with high A + T content. phylogenetic analyses based on 13 protein-coding genes (PCGs) provide strong support for monophyly each family within Pentatomomorpha. Macilentum clustered together other species Rhopalidae, and grouped sibling Aeschyntelus notatus.
Background Pituitary adenoma is one of the most common central nervous system tumors. The diagnosis and treatment pituitary remain very difficult. Misdiagnosis recurrence often occur, experienced neurosurgeons are in serious shortage. A knowledge graph can help interns quickly understand medical related to tumor. Objective aim this study was develop a data fusion method suitable for using adenomas integrated from different sources. overall goal construct (KGPA) be used discovery. Methods...
The complete mitochondrial genome of Notonecta chinensis Fallou was sequenced and 15,149 bp long with 75.6% A + T. There were 37 typical genes including 13 protein-coding (PCGs), 22 transfer RNA (tRNAs), two ribosomal (rRNAs). 531 D-loop region located between 12S rRNA trnI-Ile. All PCGs started ATN codons, except COI ND4L, ended TAA, COII, COIII, ATPase6 ND3. Phylogenetic analyses highly supported the monophyly for each superfamily. Notonectoidea formed a solid monophyletic group, N....