A5048108230- Porphyrin and Phthalocyanine Chemistry
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Bacteriophages and microbial interactions
- Adenosine and Purinergic Signaling
- DNA and Nucleic Acid Chemistry
- Synthesis and Biological Evaluation
- Photodynamic Therapy Research Studies
- Chemical Synthesis and Reactions
- Oxidative Organic Chemistry Reactions
- Cytomegalovirus and herpesvirus research
- RNA and protein synthesis mechanisms
- Tuberculosis Research and Epidemiology
- Phenothiazines and Benzothiazines Synthesis and Activities
- Fluorine in Organic Chemistry
- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- COVID-19 Clinical Research Studies
- Analytical Methods in Pharmaceuticals
- Pigment Synthesis and Properties
- Autophagy in Disease and Therapy
- Antimicrobial agents and applications
- Nanoplatforms for cancer theranostics
Frumkin Institute of Physical Chemistry and Electrochemistry
2015-2025
Royal Society of Chemistry
2024
Centre National pour la Recherche Scientifique et Technique (CNRST)
2024
Research Institute of Disinfectology Rospotrebnadzor
2020
Institute of Energy Problems of Chemical Physics
2017
Russian Academy of Sciences
2017
Abstract Despite the significance of H 2 O -metal adducts in catalysis, materials science and biotechnology, nature interactions between metal cations remains elusive debatable. This is primarily due to extremely weak coordinating ability , which poses challenges characterizing understanding specific these interactions. Herein, we present an approach obtain –metal complexes that employs neat as both solvent ligand. SnCl 4 effectively binds forming a (H ) complex, confirmed by 119 Sn 17 NMR...
Non-canonical DNA structures are widely used for regulation of gene expression, in nanotechnology and the development new DNA-based sensors. I-motifs (iMs) two intercalated parallel duplexes that held together by hemiprotonated C-C base pairs. Previously, iMs were as an accurate sensor intracellular pH measurements. However, iM stability is moderate, which turn limits its vivo applications. Here, we report rational design a substituted phenoxazine 2'-deoxynucleotide (i-clamp) stabilization....
This study reports a convenient, safe and recyclable source of anhydrous H 2 O for organic peroxide synthesis. It is based on the generation through reaction ZnO with SO 4 recycling from ZnSO 1 wt% .
Regioselective bromination of methyl pyropheophorbide a at the C3 2 -position terminal double bond has been carried out as one-pot two-step addition/elimination process. The elimination occurs with 100% stereoselectivity and bromovinyl 4 E-configuration C3-double bond. reactivity unsaturated bromide evaluated in series Pd -catalyzed coupling reactions.
A phenoxazine-based scaffold with one or two positively charged arms for selectively G4 stabilizing was synthesized and probed.
A method of direct borylation vinyl-substituted porphyrinoids (porphyrins and chlorins) has been developed based on the copper catalyzed vinylic C–H activation.
Rose Bengal (RB) is an anionic xanthene dye with multiple useful biological features, including photosensitization properties. RB was studied extensively as a photosensitizer, mostly for antibacterial and antitumor photodynamic therapy (PDT). The application of to virus inactivation rather understudied, no derivatives have been developed antivirals. In this work, we used synthetic approach based on successful design photosensitizing antivirals produce photoinactivation. A series...
Abstract Progress in RNA metabolism and function studies relies largely on molecular imaging systems, including those comprising a fluorogenic dye an aptamer-based fluorescence-activating tag. G4 aptamers of the Mango family, typically combined with duplex/hairpin scaffold, activate fluorescence green light-emitting TO1-biotin hold great promise for intracellular tracking. Here, we report new Mango-based platform. Its key advantages are tunability spectral properties applicability...
The reaction between pyropheophorbide a methyl ester (1) and hydrazine hydrate has been studied.It was shown that the reagents ratio governs particular product formation.Treatment of 1 by excess (more than 3 eq.)yielded methylmesopyropheophorbide hydrazone (2) as major product.On other hand, only azine (4) formed when equimolar amounts were applied.In order to prevent C3-vinyl group reduction in hydrate, carried out presence trifluoroacetic acid (TFA).It shown, selectivity is regulated...
Perylene-based compounds are attracting significant attention due to their high broad-spectrum antiviral activity against enveloped viruses. Despite unambiguous results of in vitro studies and selectivity index, the poor water solubility these prevented vivo evaluation properties. In this work, we synthesized a series with perylene pharmacophore bearing positively charged substituents improve aqueous unique type antivirals. Three types groups were introduced: (1) quaternary morpholinium...
Solid paraffin briquettes are one of the most modern types rodenticide baits, because they protect it from environmental exposure and do not reduce palatability rodents. This paper proposes a simple universal method for determination brodifacoum, bromadiolone difenacoum in solid briquettes, which mixture paraffin, poison filler, can be used as grain, flour like. The difficulty analysis baits containing is to get rid it. For this, we propose use hexane-acetonitrile extraction system. Paraffin...
Three recently synthesized tetrapyrrole compounds: (E)-3 2 -bromopyropheophorbide a methyl ester (1) and its derivatives with p-conjugated acrylate (2) phenyl (3) substituents are structurally characterized using X-ray diffraction along 1D 2D NMR spectroscopy.All compounds crystallized in chiral space groups.The planar molecules form stacks extended one direction.The 1 H 13 C signals were completely assigned { H, H} correlation spectroscopy (COSY), nuclear Overhauser effect (NOESY), C}...
Emerging and re-emerging viruses periodically cause outbreaks epidemics around the world, which ultimately lead to global events such as COVID-19 pandemic. Thus, urgent need for new antiviral drugs is obvious. Over more than a century of development, nucleoside analogs have proven be promising agents against diversified DNA RNA viruses. Here, we present synthesis evaluation activity their deglycosylated derivatives based on hydroxybenzo[4,5]imidazo[1,2-c]pyrimidin-1(2H)-one scaffold. The was...