A5037220298- Advanced Electron Microscopy Techniques and Applications
- Chromosomal and Genetic Variations
- Microfluidic and Bio-sensing Technologies
- Genomics and Chromatin Dynamics
- Influenza Virus Research Studies
- Advanced Fluorescence Microscopy Techniques
- interferon and immune responses
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Engine and Fuel Emissions
- Immune Response and Inflammation
- Technical Engine Diagnostics and Monitoring
- Ubiquitin and proteasome pathways
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Extracellular vesicles in disease
- Plant Molecular Biology Research
- Advanced Measurement and Detection Methods
- Advancements in Materials Engineering
- Periodontal Regeneration and Treatments
Stanford University
2020-2021
Wojskowy Instytut Techniki Pancernej i Samochodowej
2018
National Institutes of Health
2012-2015
Center for Cancer Research
2014-2015
National Cancer Institute
2014-2015
Gene Therapy Laboratory
2013
University of Virginia Health System
2009-2011
University of Virginia
2008-2010
The histone H3 variant CENP-A is normally tightly regulated to ensure only one centromere exists per chromosome. Native often found overexpressed in human cancer cells and a range of tumors. Consequently, misregulation thought contribute genome instability cancers. However, the consequences such overexpression have not been directly elucidated cells. To investigate native overexpression, we sought uncover CENP-A-associated defects We confirm that innately several colorectal cell lines. In...
The innate immune system guards against virus infection through a variety of mechanisms including mobilization the host interferon system, which attacks viral products mainly at posttranscriptional level. influenza NS1 protein is multifunctional facilitator replication, one whose actions to antagonize response. Since required for efficient it was reasoned that chemical inhibitors this could be used further understand virus-host interactions and also serve as potential new antiviral agents. A...
Influenza virus non-structural protein 1 (NS1) is the centrepiece of viral response to host interferon (IFN) system. NS1 has been demonstrated previously be a potential therapeutic target for antiviral therapy by identification specific small-molecule inhibitors. This study biological mechanism potent new antagonist. Compound JJ3297 inhibited replication more than three orders magnitude without affecting cell viability. Importantly, it efficiently reversed NS1-induced inhibition IFN mRNA...
Cryo-electron tomography is the highest resolution tool available for structural analysis of macromolecular complexes within their native cellular environment. At present, data acquisition suffers from low throughput, in part due to probability positioning a cell such that subcellular structure interest on region electron microscopy (EM) grid suitable imaging. Here, we photo-micropatterned EM grids optimally position endothelial cells so as enable high-throughput imaging cell-cell contacts....
In brief: Improved treatments for osteoarthritis and other degenerative joint diseases are urgently needed. This study demonstrates, the first time, that synovial microenvironment can be modified to allow resident skeletal stem cells form hyaline articular cartilage thereby regenerate injured cartilage.
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In the article authors have attempted to analyze specifications and criteria imposed on military vehicles acquired by Polish Armed Forces. The issues of selection target operation standard, interval between periodic maintenance inspections, fault tolerance reliability, which are defined in tactical-technical administrators, were addressed. technical essential component qualification studies. data obtained from research prototypes initial years exploitation new equipment (SpW) constitute...
The article also tackles topics related to dynamic testing of vehicles equipped with massive wheel inserts. subject matter was taken due the modernization Polish Armed Forces. majority obtained for army are wheels With introduction this solution army, there a need check correctness operation Military Vehicles Research Laboratory Institute Armoured and Automotive Technology developed research method, which authors presented in following article. Dynamic is carried out practical way by...