A5060791238- Systemic Sclerosis and Related Diseases
- Sulfur Compounds in Biology
- Mast cells and histamine
- Liver Disease Diagnosis and Treatment
- Advanced Glycation End Products research
- Dermatologic Treatments and Research
- Hormonal Regulation and Hypertension
- S100 Proteins and Annexins
- Sodium Intake and Health
- Sympathectomy and Hyperhidrosis Treatments
- Trauma and Emergency Care Studies
- Nutritional Studies and Diet
- Fibroblast Growth Factor Research
- Birth, Development, and Health
- COVID-19 Clinical Research Studies
- Nutrition and Health in Aging
- Antioxidant Activity and Oxidative Stress
- Traumatic Brain Injury Research
- COVID-19 Impact on Reproduction
- Systemic Lupus Erythematosus Research
- Alcohol Consumption and Health Effects
- SARS-CoV-2 and COVID-19 Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Biomarkers in Disease Mechanisms
- Connective Tissue Growth Factor Research
University Medical Center Groningen
2018-2025
University of Groningen
2018-2025
Center for Vascular Biology Research
2017-2020
Helsinki University Hospital
2015
University of Helsinki
2015
Serum free thiols (R-SH, sulfhydryl groups) reliably reflect systemic oxidative stress. Since serum are rapidly oxidized by reactive species, stress is generally associated with reduced thiol levels. Free associate favorable disease outcomes in many patient cohorts, and the current hypothesis that might also play an important role cardiovascular disease. In this study, we aimed to establish of general population investigating their relationship risk (CV) events all-cause...
Objective: To identify the effect of frailty and early postinjury measures on long-term outcome after mild traumatic brain injury in elderly patients. Setting: Patients admitted to 3 Dutch hospitals designated as level 1 trauma centers. Participants: The (≥60 years) with ( N = 161). Design: A prospective observational cohort study. Main Measures: Posttraumatic complaints Hospital Anxiety Depression Scale determined 2 weeks postinjury; Glasgow Outcome Extended Groningen indicator years...
Oxidative stress plays a pivotal role in the pathogenesis of cardiovascular diseases (CVD). Postmenopausal women have an increased risk developing CVD due to decreased estrogen availability, which is accompanied by oxidative stress. Serum free thiols (R-SH) provide robust and powerful read-out systemic In this study, we aimed establish serum levels explore associations between demographic, clinical, biochemical parameters related obesity for both pre- postmenopausal women. were measured...
Abstract Background & Aims Non‐alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation, inflammation and an imbalanced redox homeostasis. We hypothesized that systemic free thiol levels, as a proxy of oxidative stress, are associated with NAFLD. Methods Protein‐adjusted serum concentrations were determined in participants from the Prevention Renal Vascular End‐Stage Disease (PREVEND) cohort study (n = 5562). Suspected NAFLD was defined Fatty Liver Index...
Oxidative stress as observed in fetal growth restriction (FGR) and preeclampsia (PE) can be identified by decreased levels of systemic free thiols (FT) increased plasma ischemia-modified albumin (IMA), which may serve biomarkers maternal blood for pregnancy complications. We evaluate the performance oxidative stress-associated potential FGR PE, their relationship with clinical characteristics. A prospective pilot study was performed healthy controls women pregnancies complicated severe or...
Introduction: Menopause is associated with increased cardiovascular risk, in which oxidative stress plays a pivotal role. Systemic reflected by decreased levels of free thiols (R-SH, sulfhydryl groups), are key components the extracellular antioxidant machinery. In this study, we investigated relation between serum as marker and female phenotype, well potential associations risk (CV) events pre- postmenopausal women from general population. Methods: Female participants ( n = 2,980)...
Serum sulfhydryl groups (R-SH, free thiols) reliably reflect the systemic redox status in health and disease. As oxidation of R-SH occurs rapidly by reactive oxygen species (ROS), oxidative stress is accompanied reduced levels thiols. Oxidative has been implicated pathophysiology chronic kidney disease (CKD), which imbalance may precede onset CKD. Therefore, we aimed to investigate associations between serum thiols risk incident CKD as defined renal function decline albuminuria a...
Metabolic-associated fatty liver disease (MAFLD) is characterized by hepatic steatosis, metabolic dysregulation, and neutrophilic inflammation. In this study, we hypothesized that systemic levels of plasma calprotectin, as a biomarker inflammation, may be associated with suspected MAFLD. Plasma calprotectin were measured in subjects (n = 5446) participating the Prevention Renal Vascular ENd-stage Disease (PREVEND) cohort study. Suspected MAFLD was defined index (FLI ≥ 60) steatosis (HSI 36)...
Raynaud's phenomenon (RP) is often the first sign of systemic sclerosis (SSc). Molecular mechanisms involved are incompletely understood, but reactive oxygen, nitrogen, and sulfur species thought to play an important role in pathogenesis SSc. Free thiol groups a protective against oxidative stress may represent attractive therapeutic target. We aimed investigate effects hypothermia-induced vasoconstriction on responsiveness redox-related markers. Thirty participants (n = 10/group [SSc,...
Background: Older adults (OAs) with mild traumatic brain injury (OA-mTBI) are a growing population, but studies on long-term outcomes and quality of life scarce. Our aim was to determine the health-related (HRQoL) in OA-mTBI one year after assess early predictors HRQoL. Methods: Data from prospective follow-up study 164 older (≥60 years) 289 younger mTBI patients (<60 admitted emergency department were analyzed. Post-traumatic complaints, emotional distress coping evaluated 2 weeks...
Circulating levels of neutrophil gelatinase-associated lipocalin (NGAL) have been associated with acute kidney injury and the severity progression chronic disease (CKD). This study investigated its potential utility as a biomarker for risk new-onset CKD in population-based cohort study. Individuals without at baseline (n = 4660) who participated Prevention REnal Vascular ENd-stage Disease (PREVEND) prospective Netherlands were included. Baseline plasma NGAL concentrations their associations...
To assess whether the presence of arthritis autoantibodies alongside IgG ACPA predicts clinically suspect arthralgia in ACPA-positive subjects without RA.In population-based Lifelines cohort (n = 40 136), 308 individuals RA were present. Serum levels IgA ACPA, and IgM RF, anti-carbamylated antibodies measured at baseline. Individuals divided based on Connective tissue disease Screening Questionnaire after 2 years follow-up. Antibodies to Porphyromonas gingivalis determined baseline related...
Abstract Objective To assess the minimally invasive single-port thoracoscopic sympathicotomy feasibility and efficacy in patients with treatment-resistant RP. Methods Single-port was performed unilaterally on left side eight RP (six males, two females, a median age of 45.2 years). Five had primary three secondary Perfusion effects hands were assessed at baseline after 1 month by using cooling recovery procedure, laser speckle contrast analysis. Number duration attacks reported over 2-week...
Elderly patients are at increased risk for persistent complaints after mild traumatic brain injury (MTBI). This study aimed to investigate the role of post-concussive symptoms, mood, post-traumatic stress, and coping on functional outcome in elderly with MTBI. Information was collected 2 weeks post-injury. Six months post-injury assessed Glasgow Outcome Scale Extended. One hundred sixty-two aged ≥ 60 years were included, 55% male, mean age = 71 (±6.2) years. The most frequent cause falls...
Type 1 diabetes mellitus (T1DM) is associated with inflammation and the production of reactive oxygen species (ROS). Systemically, free thiols (R-SH) can be oxidized by ROS circulating R-SH concentrations may directly reflect systemic redox status. In this study association between clinical parameters T1DM, including glycated haemoglobin A1c (HbA1c), was investigated. This particular interest since are amendable to therapeutic intervention.As part a prospective cohort study, data from 216...
Oxidative stress plays a pivotal role in cardiovascular (CV) disease, but current biomarkers used to predict CV events are still insufficient. In this study, we comparatively assessed the utility of redox-related predicting risk and all-cause mortality male female subjects from general population. Subjects (n = 5955) Prevention REnal Vascular ENd-stage Disease (PREVEND) population-based cohort study were included. Blood homocysteine, gamma-GT, HDL cholesterol, bilirubin protein-adjusted free...
Raynaud's Phenomenon (RP) leading to repetitive ischemia and reperfusion (IR) stress, is the first recognizable sign of systemic sclerosis (SSc) increased oxidative stress. High-mobility group box-1 (HMGB1) a nuclear factor released by apoptotic necrotic cells after Since HMGB1 can signal through receptor for advanced glycation end products (RAGE), we investigated whether an RP attack promotes release HMGB1, fibroblast activation upregulation interferon (IFN)-inducible genes. A cold...