A5037239205- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Pregnancy and Medication Impact
- Gestational Diabetes Research and Management
- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Hedgehog Signaling Pathway Studies
- Prenatal Screening and Diagnostics
- Preterm Birth and Chorioamnionitis
- Cardiac Valve Diseases and Treatments
- Assisted Reproductive Technology and Twin Pregnancy
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Congenital Diaphragmatic Hernia Studies
- Maternal and fetal healthcare
- Cardiac tumors and thrombi
- Digestive system and related health
- Pancreatic function and diabetes
- Axon Guidance and Neuronal Signaling
- Cardiomyopathy and Myosin Studies
- Glioma Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Hemoglobinopathies and Related Disorders
- Mast cells and histamine
University of Groningen
2015-2025
University Medical Center Groningen
2015-2025
University of Manchester
2016
Harper University Hospital
2016
St Mary's Hospital
2016
Hutzel Women's Hospital
2016
St Mary's Hospital
2016
University Medical Center Utrecht
2016
Mount Sinai Hospital
2016
Manchester Academic Health Science Centre
2016
-The value of placental examination in investigations adverse pregnancy outcomes may be compromised by sampling and definition differences between laboratories.-To establish an agreed-upon protocol for the placenta, diagnostic criteria lesions. Recommendations would cover reporting placentas tertiary centers as well community hospitals district general hospitals, are also relevant to scientific research community.-Areas controversy or uncertainty were explored prior a 1-day meeting where...
Abstract Mitochondrial protein synthesis requires charging mt-tRNAs with their cognate amino acids by mitochondrial aminoacyl-tRNA synthetases, the exception of glutaminyl mt-tRNA (mt-tRNA Gln ). is indirectly charged a transamidation reaction involving GatCAB amidotransferase complex. Defects machinery cause broad spectrum disorders, often fatal outcome. Here, we describe nine patients from five families genetic defects in complex subunit, including QRSL1 , GATB and GATC each showing lethal...
Immune cells are critically involved in placental development and functioning. Inadequate regulation of the immune system is associated with pathology pregnancy complications. This study aimed to explore numbers decidual pregnancies complicated fetal growth restriction (FGR) stillbirth (SB), placentas histopathological lesions: maternal vascular malperfusion, delayed villous maturation, chorioamnionitis villitis unknown etiology. Placental tissue from FGR (n=250), SB (n=64) healthy (n=42)...
Abstract Background Inflammatory bowel disease (IBD) often presents during the fertile age and may affect pregnancy outcomes. Both IBD selected complications involve oxidative stress. Soluble FMS-like tyrosine kinase-1 (sFlt-1) placental growth factor (PlGF) serve as biomarkers of insufficiency, while free thiols (FT) reflect systemic This study aimed to assess dynamics FT, sFlt-1, PlGF before, during, shortly after pregnancy, their relationships with disease- outcomes in patients IBD....
Inflammatory bowel disease (IBD) often presents during the fertile age and may affect pregnancy outcomes. Both IBD selected complications involve oxidative stress. Soluble FMS-like tyrosine kinase-1 (sFlt-1) placental growth factor (PlGF) serve as biomarkers of insufficiency, while free thiols (FT) reflect systemic This study aimed to assess dynamics FT, sFlt-1, PlGF before, during, shortly after pregnancy, their relationships with disease- outcomes in patients IBD. retrospective cohort...
Oxidative stress as observed in fetal growth restriction (FGR) and preeclampsia (PE) can be identified by decreased levels of systemic free thiols (FT) increased plasma ischemia-modified albumin (IMA), which may serve biomarkers maternal blood for pregnancy complications. We evaluate the performance oxidative stress-associated potential FGR PE, their relationship with clinical characteristics. A prospective pilot study was performed healthy controls women pregnancies complicated severe or...
Intrahepatic cholestasis of pregnancy (ICP) can result in adverse outcomes for both mother and fetus. Inflammatory (M1 subset) or anti-inflammatory (M2 macrophage polarisation is associated with various diseases. However, the influence ICP on numbers remains unknown. This study analyses density distribution placentas patients compared to controls. Clinical parameters were correlated ursodeoxycholic acid use (UDCA). included routinely collected placental tissue samples 42 women diagnosed 50...
ABSTRACT Introduction : Centronuclear myopathies (CNMs) are a subtype of congenital (CMs) characterized by muscle weakness, predominant type 1 fibers, and increased central nuclei. SPEG (striated preferentially expressed protein kinase) mutations have recently been identified in 7 CM patients (6 with CNMs). We report 2 additional expanding the phenotype evaluate genotype–phenotype correlations associated mutations. Methods Using whole exome/genome sequencing families, we novel recessive...
Objectives: To assess the role of fetal brain-sparing and postnatal cerebral oxygen saturation (rcSO2) as determinants long-term neurodevelopmental outcome following growth restriction (FGR). Methods: This was a prospective follow-up study an FGR cohort 41 children. Prenatally, presence (cerebroplacental ratio < 1) assessed by Doppler ultrasound. During first two days after birth, rcSO2 measured with near-infrared spectroscopy. At 4 years age, intelligence (IQ points), behavior (T-scores),...
Background and purposeRadiotherapy during pregnancy is rarely administered due to lack of data practical challenges. This the first detailed report proton therapy as cancer treatment for a pregnant patient with nasopharyngeal carcinoma.Materials methodsPencil beam scanning was prescribed total dose 70 Gy (RBE) therapeutic CTV 54.25 prophylactic CTV, delivered in 35 fractions simultaneous integrated boost technique.ResultsPhantom measurements showed thirty-fold decrease fetal radiation when...
In Fetal Growth Restriction 'fetal programming' may take place via DNA methylation, which has implications for short-term and long-term health outcomes. Small-for-gestational age fetuses are considered fetal growth restricted, characterized by brain-sparing when Doppler hemodynamics abnormal, expressed as a cerebroplacental ratio (CPR) <1. We aimed to determine whether is associated with altered methylation of selected genes.We compared six genes in 41 small-for-gestational placentas normal...
In pregnancy, maternal physiology is subject to considerable adaptations, including alterations in cardiovascular and metabolic function as well development of immunological tolerance towards the fetus. an oocyte donation fetus fully allogeneic mother, since it carries both donor antigens paternal antigens. Therefore, pregnancies result immunologically challenging which reflected by a higher-than-normal risk develop pre-eclampsia. Based on conditions pregnancies, we hypothesized that this...
Placental pathology and pregnancy complications are associated with unfavorable regulation of the maternal immune system. Although much research has been performed towards role cells like macrophages T in this context, little is known about presence function mast (MC). MC can be sub classified tryptase-positive (MCT) tryptase- chymase-positive (MCTC). This study investigates decidua pregnancies complicated by fetal growth restriction (FGR) stillbirth (SB). tissue from FGR (n = 250), SB 64)...
Sonic hedgehog (SHH) medulloblastoma originates from the cerebellar granule neuron progenitor (CGNP) lineage, which depends on Hedgehog signaling for its perinatal expansion. Whereas SHH tumors exhibit overall deregulation of this pathway, they also show patient age-specific aberrations. To investigate whether developmental stage CGNP can account these lesions, we analyzed developing murine transcriptomes and observed highly dynamic gene expression as a function age. Cross-species comparison...
Abstract Infections with hypervirulent Klebsiella pneumoniae (hvKp) commonly presents primary liver infection, bacteremia, and metastatic abscesses. Here, we present 2 cases of severe community-acquired pulmonary infections by hvKp in patients the Netherlands without recent travel history. Both bacterial isolates are closely related to an archetype ST23 reference isolate. Based on these findings, surveillance programs may consider include from pneumonia K. .
Objective Management of late fetal growth restriction (FGR) is limited to adequate monitoring and optimal timing delivery. The Disproportionate Intrauterine Growth Intervention Trial At Term (DIGITAT) trial compared induction labor with expectant management in pregnancies at (near) term complicated by suspected FGR. Findings the DIGITAT were that prolonged pregnancy for 10 days increased birthweight only 130 grams. This resulted more infants born below 2.3rd percentile labor, respectively...
Addition of placental histopathology studies to obstetric trials is likely be cost-effective and may reveal structural changes suggestive functional dysfunction explain the success or failure a clinical intervention. We share our recent experience in adding pathological examination two trials, retrospectively one at outset other, so that other trial investigators benefit from it. The practical issues can summarised as being regulatory ethical, operational reporting. Prospective inclusion...
Background: Placental insufficiency is an important mechanism underlying early-onset fetal growth restriction (eoFGR). Reduced placental function causes impaired metabolic and gaseous exchange. This unfavorable environment among other processes characterized by increased oxidative stress. Systemic free thiols (FT) are known for their reactive oxygen species scavenging capacity, higher plasma levels of FT associated with a better outcome in multitude ischemic inflammatory diseases. We aimed...
Early onset fetal growth restriction is a common pregnancy complication with significant risk of perinatal mortality and morbidity. The most etiology placental insufficiency, reflected by several lesions that appear restriction. Placental immune cells are involved in almost all aspects the development placenta cell imbalances have been related to complications. STRIDER trial investigated therapeutic potential sildenafil. No clinical improvements were observed, however, since sildenafil can...
<title>Abstract</title> Neuronal wiring in the developing nervous system relies on axon guidance, a process which enables proper pathfinding to target cells. Disruption of guidance results wide spectrum defects including congenital mirror movements (CMM) and corpus callosum agenesis (CCA). Axon signaling pathways, such as Netrin-1/DCC, act through guanine nucleotide exchange factors (GEFs) activate Rho GTPases, regulate outgrowth pathfinding. <italic>MCF2</italic> is an X-linked gene that...