A5013620746- Bone Metabolism and Diseases
- Acupuncture Treatment Research Studies
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Muscle Physiology and Disorders
- Myofascial pain diagnosis and treatment
- Hedgehog Signaling Pathway Studies
- Congenital limb and hand anomalies
- Exercise and Physiological Responses
- Healthcare and Venom Research
- Bone health and osteoporosis research
- Musculoskeletal pain and rehabilitation
- Adipose Tissue and Metabolism
- Heterotopic Ossification and Related Conditions
- Cervical and Thoracic Myelopathy
- Autoimmune and Inflammatory Disorders Research
- Prosthetics and Rehabilitation Robotics
- Dermatological and Skeletal Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Total Knee Arthroplasty Outcomes
- S100 Proteins and Annexins
- CAR-T cell therapy research
- Bone and Joint Diseases
- Prenatal Screening and Diagnostics
- Osteoarthritis Treatment and Mechanisms
Hainan Provincial Hospital of Traditional Chinese Medicine
2015-2025
Hainan Medical University
2024-2025
Guangzhou University of Chinese Medicine
2024-2025
Third Affiliated Hospital of Southern Medical University
2020-2022
Southern Medical University
2015-2020
ORCID
2020
Luteolin, a natural flavonoid compound, has demonstrated anti-inflammatory, antioxidant, and broad anti-tumor properties. Recent studies suggest that its effects are linked to enhanced CTL function-including proliferation, survival, cytotoxicity-via inhibition of the YAP/Wnt signaling pathway in tumor cells. Consequently, luteolin potential as an adjuvant combination therapies with adoptive immunotherapy. This study first assessed luteolin's tumor-inhibitory vitro vivo using cytotoxicity...
Cranial sutures play critical roles in load distribution and neuroprotection, with their biomechanical performance intimately linked to morphological complexity. The purpose of this study was investigate the effect different morphologies cranial on behavior. Based sutures, six groups finite element models (closed, straight, sine wave, tight sinusoidal layered wave + sutural bone) bone–suture–bone composite structures that ranged from simple complex were constructed. Each model subjected 50...
Heterotopic ossification of the entheses is one most distinctive features in ankylosing spondylitis (AS). Fibroblasts are potential target cells for heterotopic ossification. The Wnt/β-catenin pathway and its inhibitor dickkopf-1 (DKK-1) regulate bone formation. DKK-1 expression human AS tissues has not been documented.The purpose current study was to investigate elucidate role fibroblasts proliferation osteogenesis AS.DKK-1 assessed by western blotting, real time-polymerase chain reaction...
Background: Heterotopic ossification on the enthesis, which develops after subsequent inflammation, is one of most distinctive features in ankylosing spondylitis (AS). Prostaglandin E2 (PGE-2) serves as a key mediator inflammation and bone remodeling AS. Celastrol, well-known Chinese medicinal herb isolated from Tripterygium wilfordii , widely used treating inflammatory diseases, including It has been proven that it can inhibit lipopolysaccharide-induced expression various mediators, such...
Skull defect repair is a complex and critical medical challenge, there an urgent need to develop multifunctional tissue engineering scaffolds for skull regeneration. The success of bone depends on the construction that can regulate immune microenvironment regeneration mimic liquid crystal viscoelastic properties natural extracellular matrix. Hence, smart hydrogel (PEGDA5/AM15/CLC-BMP-4@MBG) with good biocompatibility ability modulate wound has been developed defects. consists chitin...
Abstract Skeletal muscle atrophy coincides with extensive fibrous tissue hyperplasia in muscle‐atrophied patients, and plays a vital role skeletal function hinders fiber regeneration. However, effective drugs to manage fibrosis remain elusive. This study isolated characterized exosomes derived from satellite cells (MuSC‐Exo). The investigated their effects on denervated Sprague Dawley (SD) rats via intramuscular injection. MuSC‐Exo demonstrated the potential alleviate fibrosis. underlying...
Abstract Osteoarthritis (OA) is a progressively developing condition primarily characterized by the deterioration of articular cartilage and proliferation bone, along with ongoing inflammation. Although precise pathogenesis remains somewhat elusive, restoring homeostatic balance intra‐articular microenvironment crucial for management OA. Intra‐articular injection medication one most direct effective treatment methods; however, injectable drugs used osteoarthritis treatment, due to their...
To investigate the changes in proinflammatory cytokines and chemokines, namely, C-C motif ligand (CCL) 2 CCL7, postmenopausal osteoporosis (PMOP) to develop a new drug, bindarit (Bnd), for PMOP an ovariectomized (OVX) mouse model.Bone marrow macrophages (BMMs) from femurs of five women with premenopausal without were detected by RNA sequencing. BMMs mice differentiated into osteoclasts treated synthetic inhibitor CCL2 Bnd, or 17 beta estradiol (E2 ). Mouse Bnd 7 days analyzed Osteoblasts...
Abstract Background and objective Sympathetic activity plays an important role in the proliferation differentiation of stem cells, it changes over time, thereby exerting differential effects on various cell types. Aging causes sympathetic hyperactivity aged tissues blunts nerves regulation, abnormalities play a aging-related diseases. Currently, effect skeletal muscle namely satellite cells (SCs), is unclear. This study aimed to investigate SC aging repair. Materials methods To evaluate...
Background: There are few studies focusing on biomechanism of spinal cord injury according to the ossification posterior longitudinal ligament (OPLL) during cervical rotatory manipulation (CRM). This study aimed explore biomechanical effects CRM cord, dura matter and nerve roots with OPLL in vertebral canal. Methods: Three validated FE models craniocervical spine complex were constructed by adding mild, moderate, severe healthy model, respectively. We simulated static compression dynamic...
Background: Manual therapy (MT) has been widely used in China to treat local tissue inflammation for a long time. However, there is lack of scientific evidence using MT anti‐inflammatory therapy, and its mechanism needs further clarification. Methods: We utilized cardiotoxin (CTX) injury‐induced skeletal muscle C57BL6/J mice. analyzed the underlying by integrating single‐cell RNA sequencing (scRNA‐seq) with molecular techniques. Hematoxylin eosin (H&E) immunohistochemical (IHC) staining...
Background Postmenopausal osteoporosis (PMOP) is characterized by low bone mass and increased fragility in postmenopausal women. Shen Gu An capsule (SGA) has been clinically used to treat diseases, especially PMOP with kidney Yang deficiency. Objectives We aimed study the effect of SGA on treatment PMOP. Methodology The key candidate targets pathways for treating were predicted Network pharmacology analysis. Then, vivo validation using bilaterally ovariectomized C57BL/6 mice was performed,...
Abstract Objective To investigate the expression of inflammatory factors IL-6, IL-8, MMP-1, and MMP-3 in synovial fluid (SF) patients with osteoarthritis (OA) during electroacupuncture treatment, further analyze correlation between function severity osteoarthritis. Methods 137 knee (KOA) were collected. 128 eventually enrolled study after propensity matching analysis, including 64 group control group. K-L grading was performed according to X-rays. The treated conventional physical...
Abstract Background The definition of the entrance bicipital groove (EBG) is still unclear, and relationships between EBG lesions long head biceps brachii tendon (LBT) pulley complex (BPC) have been controversial. purpose this anatomic imaging study was to define examine morphological parameters, classifications, their with LBT BPC. Methods One hundred thirteen unpaired intact dry humeri, 34 cadaveric shoulder specimens 278 images were collected, measured, classified based on...