The reactions of seven-coordinate [FeIII(dapsox)(H2O)2]ClO4·H2O (1), [FeII(H2dapsox)(H2O)2](NO3)2·H2O (2), and [MnII(H2dapsox)(CH3OH)(H2O)](ClO4)2(H2O) (3) complexes the acyclic rigid pentadentate H2dapsox ligand [H2dapsox = 2,6-diacetylpyridinebis(semioxamazide)] with superoxide have been studied spectrophotometrically, electrochemically, by a submillisecond mixing UV/vis stopped-flow in dimethyl sulfoxide (DMSO). same studies were performed on [MnII(Me2[15]pyridinaneN5)(H2O)2]Cl2·H2O (4)...

Neural progenitor cells (NPCs) capable of self-renewal and differentiation into neural cell lineages offer broad prospects for therapy neurodegenerative diseases. However, based on NPC transplantation is limited by the inability to acquire sufficient quantities NPCs. Previous studies have found that a chemical cocktail valproic acid, CHIR99021, Repsox (VCR) promotes mouse fibroblasts differentiate NPCs under hypoxic conditions. Therefore, we used VCR (0.5 mM 3 μM 1 Repsox) induce...

Objective: To investigate the expression of LncRNA MNX1-AS1 in NSCLC and its effect on cell lines. Methods: In this experiment, was detected by qRT-PCR 116 samples, correlation between patients further analyzed chi-square test. The prognostic value assessed Kaplan-Meier survival curve. line A549 knocked down, effects proliferation, apoptosis, migration invasion cells were evaluated. Results: Compared with normal lung tissue, significantly increased cancer tissues (p<0.05). level higher than...

We have synthesized and characterized two Mn(II) seven-coordinate complexes with N5 pentadentate ligands, which contain hydrazone hydrazide groups respectively. shown that insertion of hydrazido (amido) into the ligand sphere increases negative charge chelate, without changing a donor atom set coordination geometry, radically modulate redox activity manganese complexes, is important for function as superoxide dismutase catalytic center.

Gelsemium elegans (G. elegans) as a traditional medicinal plant used in livestock production. The use of G. veterinary clinics may pose safety risks to human health.The aim this study was investigate tissue residue depletion pigs fed powder.A precise quantitation method and simultaneous semi-quantitation for multiple components independently standards pig tissues were developed the first time. two methods validated terms specificity, LODs, LOQs, linearity, accuracy, precision, matrix...

Hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising treatment strategy for patients with peritoneal metastasis of ovarian cancer. Heat shock proteins (HSPs) play an important role in cellular stress during HIPEC treatment. The aim the present study was to investigate whether paclitaxel can exert antitumor effects by inhibiting heat protein 27 (HSP27) expression Cell viability detected CCK8 assay. We used Western blot analysis detect HSP27 under hyperthermia conditions or without...

For the first time, effect of pressure on proton-coupled electron-transfer reactions two selected seven-coordinate FeIII/II(H2L)(H2O)2 systems [where H2L = 2,6-diacetylpyridine-bis(semicarbazone) and 2,6-diacetylpyridine-bis(semioxamazide), respectively] was examined. The acid−base equilibria different FeIII/II were investigated by spectrophotometric, potentiometric, electrochemical titrations. On basis obtained species distributions, pH intervals in which protonated forms studied exist...

Abstract Skeletal muscle atrophy coincides with extensive fibrous tissue hyperplasia in muscle‐atrophied patients, and plays a vital role skeletal function hinders fiber regeneration. However, effective drugs to manage fibrosis remain elusive. This study isolated characterized exosomes derived from satellite cells (MuSC‐Exo). The investigated their effects on denervated Sprague Dawley (SD) rats via intramuscular injection. MuSC‐Exo demonstrated the potential alleviate fibrosis. underlying...

To investigate the effect of radiotherapy plus recombinant human endostatin (RH-endostatin) on esophageal cancer and its mechanism.A total 50 nudemice were equally randomized into control group, combined therapy group I, II, III after inoculating with Eca109 cell suspension (1 × 10(7) cells/mL). On day grouping, injected normal saline, while 3 groups received radiotherapy; besides, was RH-endostatin 2.5, 5, 10 mg/kg respectively. After 3-week therapy, tumors each collected microvessel...

Abstract Two new cadmium(II) complexes with phenylthiourea (PTU), namely Cd(PTU)4Cl2 (1) and [Cd2(NCS)2(μ2-SCN)2(PTU)2(μ2-PTU)2] n (2), have been prepared characterized structurally by X-ray diffaction. Complex 1 crystallizes in the monoclinic space group C2/c, a = 27.057(13), b 8.108(3), c 16.751(8) Å, β 114.46°, V 3345(3) Å3, Z 4. 2 triclinic P-1, 9.336(3), 14.686(5), 16.911(5) α 71.36(2), 84.31(2), γ 72.470(10)°, 2095.0(12) Å3 The structural analysis shows that each metal atom both...

Menopausal syndrome (MS) refers to a series of symptoms with autonomic nervous system dysfunction caused by decreased sex hormones before and after menopause. Baihe Dihuang (BHDH) decoction positively affects MS, but its mechanism remains unclear. This study aimed reveal the underlying through network pharmacology. The components BHDH Decoction were found HERB, while corresponding targets obtained from Drug Bank, NPASS, Targetnet, Swisstarget databases. MS GeneCards OMIM. STRING was used...

Two complexes, [Zn(Him)2(mpa)] (1) and [Zn(Him)2(tpa)]·H2O (2) (Him = imidazole, mpa m-phthalate, tpa terephthalate), have been prepared structurally characterized, revealing two different three-dimensional hydrogen-bonded molecular architectures. Each features [Zn(Him)2(dicarboxylate)] zigzag polymeric chains intermolecular N–H…O hydrogen bonds between the uncoordinated Him nitrogen atoms carboxylate oxygen that are similar to carboxylate–histidine–zinc triad systems in zinc(II) enzymes....

Macleaya cordata extracts (MCE) are listed as feed additives in animal production by the European Food Authority. The core components of MCE mainly sanguinarine (SA) and chelerythrine (CHE). This study aims to investigate sex differences pharmacokinetics tissue residues rats.Male female rates were intragastrically administered (1.25 mg·kg-1 body weight 12.5 dose for 28 days). SA CHE concentrations determined using high-performance liquid chromatography/tandem mass spectrometry.The peak...

<sec><title>Objective</title> To establish a methodological system for reprogramming rat embryonic fibroblasts (REF) into chemically induced neurons (ciNCs) via small molecule compounds to provide safe and effective donor cells treatment of neurodegenerative diseases. </sec><sec><title>Methods</title> Based on the method established by PEI Gang's research group directly reprogram human neurons, induction medium maturation was optimized replacing coating solution, mitigating oxidative stress...

This article explores the teaching reform of Numerical Analysis course through "Four Integration" model to enhance quality. Based on Outcome-Based Education (OBE) concept, interdisciplinary integration, ethics education, and combination industry, academia, a systematic plan is proposed. By introducing mathematical modeling experiment cases, combined with enterprise projects university student innovation projects, study found that significantly enhances students' scientific computing skills...

Background: Manual therapy (MT) has been widely used in China to treat local tissue inflammation for a long time. However, there is lack of scientific evidence using MT anti‐inflammatory therapy, and its mechanism needs further clarification. Methods: We utilized cardiotoxin (CTX) injury‐induced skeletal muscle C57BL6/J mice. analyzed the underlying by integrating single‐cell RNA sequencing (scRNA‐seq) with molecular techniques. Hematoxylin eosin (H&amp;E) immunohistochemical (IHC) staining...

Objective: To investigate the effect of titanium mesh on flail chest and bone healing from clinical animal experiments. Methods: Clinical experiment: 24 patients with chests in our hospital January 2020 to 2023 were prospectively selected divided into control groups according different treatment plans basic data‐matching principles, 12 cases each group. The group was treated conservative external fixation, fixation. efficacy index, visual analog scale blood gas indexes hemodynamic two...

To observe the effect of electroacupuncture (EA) preconditioning on podocytes and phosphatase tension homologous protein (PTEN)/phosphoinositide-3-kinase (PI3K) signaling pathway in rats with type 2 diabetic kidney injury, so as to explore its potential mechanisms.