A5101605809- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Cancer Cells and Metastasis
- Kruppel-like factors research
- Mycobacterium research and diagnosis
- Endoplasmic Reticulum Stress and Disease
- PI3K/AKT/mTOR signaling in cancer
- Lung Cancer Treatments and Mutations
- RNA and protein synthesis mechanisms
- Caveolin-1 and cellular processes
- Advanced MRI Techniques and Applications
- Forensic and Genetic Research
- Proteoglycans and glycosaminoglycans research
Asan Medical Center
2024
University of Ulsan
2024
Catholic University of Korea
2014-2024
Ulsan College
2024
Seoul National University
2019-2020
Background/Aims: Patients with advanced hepatocellular carcinoma (HCC) have a poor prognosis due to the lack of effective systemic therapies. Epithelial-to-mesenchymal transition (EMT) is pivotal event in tumor progression, during which cancer cells acquire invasive properties. In this study, we investigated effects phosphatidylinositol 3-kinase (PI3K) inhibitors, including LY294002 and idelalisib, on EMT features HCC vitro.Methods: Human cell lines, Huh-BAT HepG2, were used study. Cell...
Abstract Endometriosis consists of ectopic endometrial epithelial cells (EEECs) and stromal (EESCs) mixed with heterogeneous cells. To address how endometriosis‐constituting are different from normal endometrium among endometriosis subtypes their molecular signatures related to phenotypic manifestations, we analyzed ovarian cyst (OEC), superficial peritoneal (SPE), deep infiltrating (DIE) 12 patients using single‐cell RNA‐sequencing (scRNA‐seq). We identified 11 cell clusters, including...
Abstract Distant metastasis, the leading cause of cancer death, is efficiently kept in check by immune surveillance. Studies have uncovered peripheral natural killer (NK) cells as key antimetastatic effectors and their dysregulation during metastasis. However, molecular mechanism governing NK cell dysfunction links to metastasis remains elusive. Herein, MAP4K1 encoding HPK1 aberrantly overexpressed dysfunctional periphery metastatic site. Conditional overexpression suffices exacerbate...
Both strain and rate (SR) measure the regional myocardial deformation can assess phasic left atrial (LA) function. However, there is still a lack of evidence for their volume independency. In this study, SR determined by tissue Doppler imaging were used to evaluate effect preload reduction in end-stage renal disease patients who undergoing regular haemodialysis (HD). Forty-one subjects underwent transthoracic echocardiography just before after HD enrolled. LA was measured during late...
11q13 region is a frequently amplified locus in human malignancies. Among the genes located this region, FADD one of alleged driving genes. Because amplification not generally confined to single gene and may show increased expression, we need evaluate clinical significance changes occurring understand their roles carcinogenesis. Therefore, screened expressions closely (PPFIA1 TMEM16A) evaluated find invasive ductal carcinoma breast. Ninety-eight cases breast were collected. Using archival...
To better understand the mechanisms of SDC1 expression in invasive ductal carcinoma, we studied correlations between and related gene expressions (RSPO1, WNT1, WT1, P16). Using 100 cases carcinoma tissue, screened RSPO1, P16, using immunohistochemistry. We analyzed association immunoreactivities clinicopathological parameters. WT1 was associated with tumor grade. RSPO1 progesterone receptor expression. Expressions P16 were significantly disease-free survival. showed statistically significant...
Extremely small amounts of fatty acids detected in latent fingerprints are important for studying fingerprint visualization and age determination through changes composition over time. However, methods efficiently extracting or recovering from have not been extensively studied. If accurate stable quantitative estimations established, estimates will be possible a better understanding the acid composition. The extraction solvent treatment method essential factors achieving reliable analysis...