A5102750865- CRISPR and Genetic Engineering
- Erythropoietin and Anemia Treatment
- Innovations in Medical Education
- PARP inhibition in cancer therapy
- HIV Research and Treatment
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Artificial Intelligence in Healthcare and Education
- Pancreatic function and diabetes
- Phagocytosis and Immune Regulation
- Radiomics and Machine Learning in Medical Imaging
- HIV/AIDS drug development and treatment
- Radiology practices and education
- Diabetes Management and Research
- Machine Learning in Healthcare
- Iron Metabolism and Disorders
- Flow Measurement and Analysis
- Psychological and Temporal Perspectives Research
- Transplantation: Methods and Outcomes
- Diversity and Career in Medicine
- Medical Education and Admissions
- Climate Change and Health Impacts
- Clinical Reasoning and Diagnostic Skills
- Advanced Breast Cancer Therapies
- Cardiovascular Syncope and Autonomic Disorders
University of California, San Francisco
2015-2025
Broad Center
2023-2025
Lyell McEwin Hospital
2018-2024
The University of Adelaide
2024
University of Toronto
2020
Hospital for Sick Children
2020
SickKids Foundation
2020
Howard Hughes Medical Institute
2018
University of California, Berkeley
2015
Western University
2008
Gut microbes can profoundly modulate mucosal barrier-promoting Th17 cells in mammals. A salient feature of HIV/simian immunodeficiency virus (SIV) immunopathogenesis is the loss cells, which has been linked to increased activity immunomodulatory enzyme, indoleamine 2,3-dioxygenase 1 (IDO 1). The role gut this system remains unknown, and SIV-infected rhesus macaque provides a well-described model for HIV-associated immune disruption. We observed specific depletion gut-resident Lactobacillus...
Blood transfusion plays a vital role in modern medicine, but frequent shortages occur. Ex vivo manufacturing of red blood cells (RBCs) from universal donor offers potential solution, yet the high cost recombinant cytokines remains barrier. Erythropoietin (EPO) signaling is crucial for RBC development, and EPO among most expensive media components. To address this challenge, we develop highly optimized small molecule-inducible synthetic receptors (synEPORs) using design-build-test cycles...
Large language models (LLMs) can answer expert-level questions in medicine but are prone to hallucinations and arithmetic errors. Early evidence suggests LLMs cannot reliably perform clinical calculations, limiting their potential integration into workflows. We evaluated ChatGPT's performance across 48 medical calculation tasks, finding incorrect responses one-third of trials (n = 212). then assessed three forms agentic augmentation: retrieval-augmented generation, a code interpreter tool,...
Pharmacologic inhibition of the mammalian target rapamycin (mTOR) in setting renal transplantation has previously been associated with lower human immunodeficiency virus 1 (HIV-1) DNA burden, and vitro studies suggest that mTOR may lead to HIV transcriptional silencing. Because prospective clinical trials are lacking, we conducted an open-label, single-arm study determine impact broad inhibitor, everolimus, on residual gene expression profiles, immune responses HIV-infected adult solid organ...
Accumulation of excess air and water in the lungs leads to breakdown respiratory function is a common cause patient hospitalization. Compact non-invasive methods detect changes lung fluid accumulation can allow physicians assess patients' conditions. In this paper, an acoustic transducer digital stethoscope system are proposed as targeted solution for clinical need. Alterations structure lead measurable which be used pathology. We standardize procedure by sending controlled signal through...
Abstract Alpha-thalassemia is an autosomal recessive disease with increasing worldwide prevalence. The molecular basis due to mutation or deletion of one more duplicated α-globin genes, and severity directly related the number allelic copies compromised. most severe form, α-thalassemia major (αTM), results from loss all four has historically resulted in fatality utero . However, transfusions now enable survival birth. Postnatally, patients face challenges similar β-thalassemia, including...
A bstract Prior work has shown that large language models (LLMs) have the ability to answer expert-level multiple choice questions in medicine, but are limited by both their tendency hallucinate knowledge and inherent inadequacy performing basic mathematical operations. Unsurprisingly, early evidence suggests LLMs perform poorly when asked execute common clinical calculations. Recently, it been demonstrated capability of interacting with external programs tools, presenting a possible remedy...
Abstract Blood transfusion plays a vital role in modern medicine. However, availability is contingent on donated blood, and frequent shortages pose significant healthcare challenge. Ex vivo manufacturing of red blood cells (RBCs) derived from universal donor O-negative pluripotent stem emerges as solution, yet the high cost recombinant cytokines required for ex erythroid differentiation remains major barrier. Erythropoietin (EPO) signaling through EPO receptor indispensable to RBC...
<title>Abstract</title> Blood transfusion plays a vital role in modern medicine. However, availability is contingent on donated blood, and frequent shortages pose significant healthcare challenge. <italic>Ex vivo </italic>manufacturing of red blood cells (RBCs) derived from universal donor O-negative pluripotent stem emerges as solution, yet the high cost recombinant cytokines required for <italic>ex vivo</italic> erythroid differentiation remains major barrier. Erythropoietin (EPO)...
Problem: Effective patient-centered communication is a core competency for physicians. However, both seasoned providers and medical trainees report decreased confidence in leading conversations on sensitive topics such as goals of care or end-of-life discussions. The significant administrative burden the resources required to provide dedicated training difficult has been long-standing problem education. Approach: In this work, we present novel educational tool designed facilitate...
Abstract Background The International Federation for Emergency Medicine (IFEM) published its model curriculum medical student education in emergency medicine 2009. Because of the evolving principles and education, driven by societal, professional, educational developments, there was a need an update on IFEM recommendations. main objective process creating Intended Learning Outcomes (ILOs) providing tier-based Method A consensus methodology combining nominal group modified Delphi methods...
<title>Abstract</title> Blood transfusion plays a vital role in modern medicine. However, availability is contingent on donated blood, and frequent shortages pose significant healthcare challenge. Ex vivo manufacturing of red blood cells (RBCs) derived from universal donor O-negative pluripotent stem emerges as solution, yet the high cost recombinant cytokines required for ex erythroid differentiation remains major barrier. Erythropoietin (EPO) signaling through EPO receptor indispensable to...
<h3>Background</h3> Repetitive elements are suppressed in normal tissues but commonly expressed cancer, where methylation changes can lead to their reactivation. Combined with dysregulation of splicing machinery, this leads an increase the number RNA repeat-gene 'fusions': transcripts derived from junctions between protein-coding genes and repetitive elements. These fusions have potential be a rich source highly tumor-specific cancer vaccine targets. <h3>Methods</h3> ROME has developed...
BackgroundOral hypoglycemic agents are a frequent cause of hypoglycemia in nondiabetic people. Here, we report case recurrent caused by glipizide, which diagnosis was delayed because combination agent screening and low sensitivity the panel used.Case ReportA 66-year-old woman repeatedly presented with symptomatic hypoglycemia. At first presentation, serum glucose level 40 mg/dL (2.2 mmol/L), C-peptide 13.1 ng/mL (0.8-3.1 ng/mL), proinsulin 96.9 pmol/L (<18.8 pmol/L), insulin 164 mU/L (<17...
Introduction: In patients with type 1 diabetes mellitus, glucose homeostasis can be re-established allogeneic islet transplantation. This approach has the advantage of overcoming surgical morbidity whole pancreas transplant. However, widespread applicability both therapies is limited by a paucity deceased donors. Pluripotent stem cell-derived islets offer potentially renewable source functional beta cells, but major limitation risk teratoma formation following Therefore, for transplantation...