A5056826043- Textile materials and evaluations
- Material Properties and Applications
- Polymer crystallization and properties
- Fiber-reinforced polymer composites
- Recycling and Waste Management Techniques
- biodegradable polymer synthesis and properties
- Monoclonal and Polyclonal Antibodies Research
- Metabolomics and Mass Spectrometry Studies
- Bioeconomy and Sustainability Development
- Immunotherapy and Immune Responses
- Protein purification and stability
- Analytical Chemistry and Chromatography
- Advanced Fiber Optic Sensors
- Microplastics and Plastic Pollution
- Arctic and Russian Policy Studies
- Immune cells in cancer
- Global Trade and Competitiveness
- Mass Spectrometry Techniques and Applications
- Ergonomics and Human Factors
- Chemistry and Stereochemistry Studies
- Environmental Impact and Sustainability
- Additive Manufacturing and 3D Printing Technologies
- Material Properties and Processing
- Optimization and Packing Problems
- Polymer Nanocomposites and Properties
Technion – Israel Institute of Technology
2019-2023
Tel Hai Academic College
2009-2017
Migal - Galilee Technology Center
2009-2017
Optech (Canada)
2008-2015
Research Institute of Synthetic Fiber with the Pilot Plant
1970-1988
The inability to inspect metabolic activities within subcellular compartments has been a major barrier our understanding of eukaryotic cell metabolism. Here, we describe spatial-fluxomics approach for inferring fluxes in mitochondria and cytosol under physiological conditions, combining isotope tracing, rapid fractionation, LC-MS-based metabolomics, computational deconvolution, network modeling. Applied study reductive glutamine metabolism cancer cells, shown mediate fatty acid biosynthesis...
Mass spectrometry based metabolomics is a widely used approach in biomedical research. However, current methods coupling mass with chromatography are time-consuming and not suitable for high-throughput analysis of thousands samples. An alternative flow-injection (FI-MS) which samples directly injected to the ionization source. Here, we show that sensitivity Orbitrap FI-MS limited by ion competition effect. We describe an overcoming this effect analyzing distribution m/z values...
Summary The immune response against hapten is T‐cell‐dependent, and so requires the uptake, processing presentation of peptides on MHC class II molecules by antigen‐presenting cells to specific T cell. Some haptens, following conjugation available free amines surface carrier protein, can reduce its immunogenicity. purpose this study was explore mechanism which occurs. Four proteins were tested as carriers six used haptens. reduced > 100‐fold some haptens (termed immunogenicity reducing –...
In the kidney, low urinary citrate increases risk for developing kidney stones, and elevation of luminal succinate in juxtaglomerular apparatus renin secretion, causing hypertension. Although association between stone formation hypertension is well established, molecular mechanism linking these pathophysiologies has been elusive.To investigate relationship citrate/oxalate levels, we assessed blood urine levels metabolites, renal protein expression, BP (using 24-hour telemetric monitoring)...
Low nephron number at birth is associated with a high risk of CKD in adulthood because nephrogenesis completed
The inability to inspect metabolic activities within distinct subcellular compartments has been a major barrier our understanding of eukaryotic cell metabolism. Previous work addressed this challenge by analyzing metabolism in isolated organelles, which grossly bias activity. Here, we describe method for inferring physiological fluxes and metabolite concentrations mitochondria cytosol based on isotope tracing experiments performed with intact cells. This is made possible computational...
Proteins and peptides have been used as drugs for almost a century. Technological advances in the past 30 years enabled production of pure, stable proteins vast amounts. In contrast, administration based on their native active conformation (and thus necessitating use subcutaneous injections) has remained solely unchanged. The therapeutic anti-HER2 humanized monoclonal immunoglobulin (IgG) Trastuzumab (Herceptin) is first line treatment breast cancer. Chicken IgY commercially important...