A5101673487- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Platelet Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Spinal Dysraphism and Malformations
- Antiplatelet Therapy and Cardiovascular Diseases
- Topological Materials and Phenomena
- Heart Rate Variability and Autonomic Control
- Sperm and Testicular Function
- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Inflammatory Biomarkers in Disease Prognosis
- Quantum and electron transport phenomena
- Cardiac Imaging and Diagnostics
- Urologic and reproductive health conditions
- Monoclonal and Polyclonal Antibodies Research
- Neurological Disease Mechanisms and Treatments
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Advanced MRI Techniques and Applications
- Calcium signaling and nucleotide metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Sirtuins and Resveratrol in Medicine
- Wnt/β-catenin signaling in development and cancer
- Synthesis of β-Lactam Compounds
Hefei University
2024
Fudan University
2022-2024
Collaborative Innovation Center of Advanced Microstructures
2022-2024
State Key Laboratory of Surface Physics
2024
Capital Medical University
2016-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020-2024
Chongqing Medical University
2020-2024
Beijing Chao-Yang Hospital
2016-2024
Northwest A&F University
2013-2023
Chinese PLA General Hospital
2023
The functions of platelets and fibrinogen in protecting tumor cells from natural killer cytotoxicity have been discussed for more than 20 years. However, their exact roles relationships the process are still not clear. In this study, we show that prefer to adhere platelets, can enhance adhesion platelets. Beta3 integrin plays an important role B16F10 enhanced by fibrinogen. presence thrombin, forms dense fibrin(ogen) layers around cells. Tumor induce aggregate form thrombin. Platelets, as...
Seminal plasma ingredients are important for maintenance of sperm viability. This study focuses on the effect boar seminal exosomes function during long-term liquid storage. Boar had typical nano-structure morphology as measured by scanning electron microscopy (SEM) and molecular markers such AWN, CD9 CD63 western blot analysis. The parameters adding different ratio to preparations was analyzed. Compared diluent without exosomes, with four times or sixteen compared original semen higher...
The nucleocapsid (N) protein of severe acute respiratory syndrome-coronavirus (SARS-CoV) is a major virion structural protein. In this study, two epitopes (N1 and N2) the N SARS-CoV were predicted by bioinformatics analysis. After immunization with peptides, peptides-specific antibodies isolated from immunized rabbits. further experiments demonstrated that N1 peptide-induced polyclonal had high affinity to bind E. coli expressed SARS-CoV. Furthermore, it was confirmed peptide-specific IgG...
The mu-opioid receptor (MOR), a membrane-bound G protein-coupled receptor, is the main target for opioids in nervous system. MOR1 has been found several types of cancer cells and reported to be involved tumor progression metastasis. However, expression clinical significance esophageal squamous cell carcinoma (ESCC) remain unclear. In our study, was confirmed ESCC lines (KYSE180, KYSE150, EC109) by Western blot. also detected on tissue microarrays samples 239 cases using immunohistochemical...
Previous studies have shown that sirtuin 1 (SIRT1) reduces the production of neuronal amyloid beta (Aβ) and inhibits inflammatory response glial cells, thereby generating a neuroprotective effect against Aβ neurotoxicity in animal models Alzheimer's disease. However, protective SIRT1 on astrocytes is still under investigation. This study established time point model for clearance primary astrocytes. Results showed 12 hours culture was sufficient endocytosis oligomeric Aβ, 36 effective...
Key Points Coordinated thromboxane A2 and ADP/P2Y12 signaling is required for platelet accumulation in the outer shell region of hemostatic plugs. Platelet activation within plug core predominantly mediated by thrombin.
Abstract The adhesion of tumor cells with platelets is important in the process metastasis. A huge work has indicated that anti‐adhesion an effective strategy for metastasis inhibition. In this article, we assess role platelet integrin α IIb β 3 melanoma to and effects heparin modified heparins on vitro vivo . We show involved interaction human A375 platelets, high affinity epitope resides subunit rather than subunit. Heparin sulfate‐like proteoglycans cell surface are implicated also...
To investigate the incidence of carotid artery (CA) and vertebral (VA) stenosis by contrast-enhanced MR angiography (CE-MRA) in patients with nasopharyngeal carcinoma (NPC) after radiotherapy.72 NPC radiotherapy more than 3 years ago were recruited as irradiation group to degree CA VA CE-MRA. The results compared those control group, which comprised 50 newly diagnosed who had not received radiotherapy.There was a higher terms patient number well vessel involvement. significant (>50%)...
Abstract As one of the most destructive pests, aphids cause significant damage on various agricultural and horticultural crops. Recently, melatonin has been shown to enhance plant resistance aphids; however, underlying mechanisms remain unclear. In this study, our results showed that melatonin, MeJA, H 2 S enhanced aphid watermelon in a dose‐dependent manner, accompanied by increases defense‐related enzyme activities lignin accumulation. On plants pretreated with 100 μM 50 NaHS, numbers were...
Generally, the dissipationless Hall effect in solids requires time-reversal symmetry breaking (TRSB), where TRSB induced by external magnetic field results ordinary effect, while caused spontaneous magnetization gives rise to anomalous (AHE) which scales with net magnetization. The AHE is therefore not expected antiferromagnets vanishing small However, large was recently observed certain noncollinear spin structure and nonvanishing Berry curvature. Here, we report another origin of a layered...
The aim of this study was to evaluate prognostic values ambulatory blood pressure (ABP) and clinic (CBP) in diabetic patients with hypertension. A total 450 hypertensive without established cardiovascular diseases were enrolled 416 who had finished 12months' follow-up included final analysis. Baseline data collected Cox proportional hazards regression analysis used value ABP CBP. Compared those endpoints (n = 370), experienced 46) more elderly likely be male, longer hypertension duration...
In the present study, trehalose was utilized to improve primary culture of mouse epididymal epithelial cells in vitro, and enhance naked DNA delivery epididymis vivo. During six-day culture, proliferation activity medium with addition higher than that those cultured absence (p<0.01). To determine optimal concentration for cell proliferation, a series concentrations (0, 60, 120, 180 mM) were tested, result indicated 120 mM showed highest potential. The containing upon 16th passage, they...
The aim of current study was to evaluate sex-specific cardiac and vascular responses hypertension in Chinese populations without overt cardiovascular disease.This a cross-sectional participants were enrolled outpatient clinic between January 2017 December 2019. Transthoracic echocardiographic measurements performed structure function.Among 486 participants, women account for 36.2% (n = 176). Compared men, younger, had shorter duration hypertension, more likely be abdominal obesity. Mean...
Fetal repair of myelomeningocele (MMC) has been proven to be beneficial for the central nervous system development; however, effect fetal MMC on bladder function remains controversial. The objective present study was establish an early timepoint in utero using a rat model, and investigate changes development subsequent that intervention. Sprague Dawley rats were divided into MMC, control groups. fetus models created by treating pregnant with all‑trans retinoic acid. defect then repaired at...
Object The relationship between PR interval prolongation during hospitalization and long-term prognosis in patients with acute ST-segment elevation myocardial infarction (STEMI) has not been elucidated. This study aimed to evaluate the prevalence, predictors, outcomes of a prospective cohort post-STEMI. Methods values ionized calcium were calculated as mean level two measurements hospitalization. Variables from univariate analysis associated included multivariable logistic regression using...
Hypertension is known as a major factor for global mortality. We aimed to investigate the role of Cullin3 (CUL3) in regulation hypertension.Human vascular smooth muscle cells (VSMCs) were treated with Angiotensin II (Ang II) establish hypertension vitro model. Cell viability was detected by cell counting kit-8 (CCK-8) assay. The content reactive oxygen species (ROS) evaluated kit. Transwell assay and TUNEL staining were, respectively, used assess migration apoptosis. Additionally, expression...