A5048251142- Congenital Heart Disease Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal Respiratory Health Research
- Anesthesia and Sedative Agents
- Cardiac Arrest and Resuscitation
- Healthcare professionals’ stress and burnout
- Congenital heart defects research
- Anesthesia and Neurotoxicity Research
- Mitochondrial Function and Pathology
- Tracheal and airway disorders
- Respiratory Support and Mechanisms
- Diversity and Career in Medicine
- Innovations in Medical Education
- Congenital Diaphragmatic Hernia Studies
- Pediatric Pain Management Techniques
- Mechanical Circulatory Support Devices
- Medical Education and Admissions
- Cystic Fibrosis Research Advances
- Aortic Disease and Treatment Approaches
- Pericarditis and Cardiac Tamponade
- Inhalation and Respiratory Drug Delivery
- Hospital Admissions and Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Biomedical and Engineering Education
- Cardiovascular Conditions and Treatments
University of Pittsburgh
2015-2024
Children's Hospital of Pittsburgh
2015-2023
UPMC Health System
2022
Westmead Hospital
2016
Florey Institute of Neuroscience and Mental Health
2016
La Trobe University
2016
Monash Health
2016
Monash University
2016
Deakin University
2016
Eastern Health
2016
Abstract Aim Nasal cannulas are used to provide oxygen support for infants and have been considered as a means delivering aerosols the lungs. To measure mucociliary clearance in lungs of with congenital heart defects, we delivered radiopharmaceutical via nasal cannula. Here report on pulmonary deposition these aerosols. Method A total 18 (median age = 26 days; quartiles 11‐74 days) performed measurements soon before or after corrective cardiac surgery. The regional aerosol was assessed using...
Examine the relationship between perioperative renal regional tissue oximetry, urinary biomarkers, and acute kidney injury in infants after congenital cardiac surgery with cardiopulmonary bypass.Prospective, observational.Cardiac operating room ICU.Neonates without history of or anatomic abnormality.None.Renal oximetry was measured intraoperatively for 48 hours postoperatively. Urinary levels neutrophil gelatinase-associated lipocalin inhibitor metalloproteinases 2 together insulin-like...
Primary ciliary dyskinesia (PCD), a disease of impaired respiratory cilia motility, is often difficult to diagnose. Recent studies show low nasal nitric oxide (nNO) closely linked PCD, allowing the use nNO measurement for PCD assessments. Nasal NO cutoff values are stratified by age, given levels normally increase with age. However, normative have not been established infants less than 1 year old. In this study, we aim establish in and determine their utility guiding infant assessment.We...
ABSTRACT Background Travel costs and application fees make in-person residency interviews expensive, compounding existing financial burdens on medical students. We hypothesized virtual (VI) would be associated with decreased for applicants compared to (IPI) but at the expense of gathering information which assess program. Objective To survey senior students postgraduate year (PGY)-1 residents regarding their burden program perception during versus interviews. Methods The authors conducted a...
We use a non-invasive MRI proxy of neurovascular function (pnvf) to assess the ability vasculature supply baseline metabolic demand, compare pediatric and young adult congenital heart disease (CHD) patients normal referents relate neurocognitive outcomes nitric oxide bioavailability. In prospective single-center study, resting-state blood-oxygen-level-dependent (BOLD) arterial spin labeling (ASL) scans were successfully obtained from 24 CHD (age = 15.4 ± 4.06 years) 63 14.1 3.49) years. Pnvf...
The Bristol Stool Form Scale (BSFS) and a modified child-friendly version (M-BSFS) are frequently used in clinical practice research. These scales have not been validated children. 3-D stool scale models may be better adapted to the child's development.To assess usefulness of BSFS, M-BSFS, newly developed children.Fifty children were asked rank picture cards BSFS from hardest softest match pictures with descriptors for each type.Thirty percent appropriately characterized stools as hard,...
NO bioavailability has not been systematically examined in congenital heart disease (CHD). To assess patients with CHD, we measured nasal (nNO) generated by the epithelia, given blood is difficult to measure (half-life, <2 ms). Given NO's role hemodynamic regulation and association of failure risk, hypothesized levels may differ varying severity CHD physiologic characteristics.Six-hundred eighteen subjects, 483 135 controls, had nNO noninvasively via nares using American Thoracic...
Summary Hypoplastic left heart syndrome (HLHS) is a severe congenital defect with 30% mortality from failure (HF) in the first year of life, but why only some patients suffer early-HF and its cause remain unknown. Modeling using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) showed patient iPSC-CM have increased apoptosis, redox stress, failed antioxidant response. This was associated mitochondrial permeability transition pore (mPTP) opening, hyperfusion respiration defects....
Background: Infants undergoing congenital cardiac surgery with cardiopulmonary bypass are at high risk for respiratory complications. As impaired airway mucociliary clearance (MCC) can potentially contribute to pulmonary morbidity, our study objective was measure in infants and examine correlation clinical covariables that may impair function. Materials Methods: Airway measured over 30 min using inhaled nebulized Technetium 99m sulfur colloid administered either via a nasal cannula or the...
Strategies to prevent or reduce burnout for anesthesiology residents remain relatively unexplored. We aimed determine if participation in a wellness course would be associated with lower burnout.A prospective, case-control survey/questionnaire study was implemented within single residency large academic medical center program. One class participated an inaugural (n = 15) promoting particular principles 4 months into their postgraduate year (PGY)-1, while another no served as controls 13)....