A5101809763- Airway Management and Intubation Techniques
- Anesthesia and Sedative Agents
- CRISPR and Genetic Engineering
- Anesthesia and Pain Management
- Tracheal and airway disorders
- Enzyme Catalysis and Immobilization
- Cancer, Hypoxia, and Metabolism
- Viral Infections and Immunology Research
- Respiratory Support and Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Microbial Metabolic Engineering and Bioproduction
- MicroRNA in disease regulation
- Computational Drug Discovery Methods
- interferon and immune responses
- Nausea and vomiting management
- Cancer, Stress, Anesthesia, and Immune Response
- Cardiac, Anesthesia and Surgical Outcomes
- Cytomegalovirus and herpesvirus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Analytical Chemistry and Chromatography
- RNA and protein synthesis mechanisms
- HIV/AIDS drug development and treatment
- Cancer Immunotherapy and Biomarkers
- Influenza Virus Research Studies
- Pediatric Pain Management Techniques
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Soochow University
2023-2025
81th Hospital of PLA
2024
The 180th Hospital of PLA
2012-2023
Soochow University
2023
University of Pennsylvania
2020
Shanghai Jiao Tong University
2019
University of Electronic Science and Technology of China
2017
Chinese People's Liberation Army
2013
Hypoxaemia is frequently seen during flexible bronchoscopies that are done with a nasal approach under the traditional sedation propofol. This study investigated potential benefits of supraglottic jet oxygenation and ventilation (SJOV) using Wei tube (WNJ) in reducing hypoxaemia patients undergoing bronchoscopy moderate to deep intravenous propofol, lidocaine remifentanil cocktail.
The emergency difficult airway with the 'cannot intubate and cannot ventilate' (CICV) situation contributes to a high percentage of anesthesia- medicine-related morbidity mortality. A new technique supraglottic jet oxygenation ventilation (SJOV) via nasal approach was successfully used in an save patient CICV from catastrophic outcome.
A study of the enzymatic synthesis a chiral 2,3-dihydro-1,4-benzodioxane motif using engineered Candida antarctica lipase B with novel method based on covariant amino acids.
Covariant residues identified by computational algorithms have provided new insights into enzyme evolutionary routes. However, the reliability and accuracy of routine statistical coupling analysis (SCA) are unable to satisfy needs protein engineering because SCA depends only on sequence information. Here, we set up a algorithm, SCA.SIM, integrating structure information MD simulation data. The more reliable covariant with high-quality scores obtained from alignment weighted residual movement...
Supraglottic jet oxygenation/ventilation (SJOV) can reduce hypoxemia in sedated endoscopy but may increase minor side effects like pharyngalgia and xerostomia. This study aimed to identify risk factors for pharyngalgia/xerostomia with SJOV during gastrointestinal endoscopy. From January 1 December 31, 2021, 5313 patients propofol sedation underwent or removal of polyps was analyzed retrospectively. Data included patient characteristics, operation details, postoperative adverse events,...
Abstract The activation of glycolysis, particularly in the context reprogrammed energy metabolism, is increasingly recognized as a significant characteristic cancer. However, precise mechanisms by which glycolysis promoted metastatic gastric cancer cells under normal oxygen conditions remain poorly understood. MicroRNAs (miRNAs) play crucial role development malignant phenotypes Nevertheless, our understanding specific involvement miRNAs hypoxia-induced metabolic shifting and subsequent...
<title>Abstract</title> <bold>Background: </bold>Increasing gastric volume is one of the main risk factors associated with pulmonary aspiration. Supraglottic jet oxygenation and ventilation (SJOV) using WEI Nasal Jet Tube (WEI JET, WNJ) a developing technique, increasingly used to promote during moderate deep sedation difficult airway management. However, its potential increase has not been investigated. <bold>Methods:</bold> This prospective, randomized, double-blind clinical study....
Objective To investigate the safety and effectiveness of 0.5% different volume isobaric ropivacaine for spinal anesthesia in elderly patients undergoing hip surgery. Methods Aged≥60, American Society Anesthesiologists (ASA) Ⅰ~Ⅳ patients, elective surgery, were randomly divided by a form randomized numbers into three (A, B, C) groups (n=63/group). Lumbar puncture at L3~4 interspinous spaces was performed non-surgical lateral decubitus all patients. A percentage (1%) diluted to with...
Objective To observe the effect of acute normovolemic hemodilution (ANH) combine with low central venous pressure (LCVP) on regulatory T cells and natural killer (NK) in patients undergoing liver cancer resection.Methods The Sixty-six right operation operated by same surgeon were equally randomized into three groups ANH,LCVP,or ANH+LCVP,respectively.Peripheral blood was extracted postoperative days 0(T0),1(T1),3(T2),5(T3) to determine immune function including NK cells.Results Compare T0,the...
Objective To evaluate the effects of different blood-saving strategies on postoperative cellular immune function in patients undergoing resection for liver cancers.Methods Sixty-six ASA physical status Ⅰ or Ⅱ patients,aged 25-64 yr,with hepatocellular carcinoma classification G1-G3 and clinicopathological staging Ⅰ-Ⅳ,undergoing elective cancers,were randomly divided into 3 groups (n =22 each) using a random number table:low central venous pressure group (L group),acutenormovolemic...
Objective To compare the efficacy of combined intravenous-inhalational anesthesia with propofol-fentanyl-sevoflurane in children undergoing minor surgery under spontaneous breathing nasopharyngeal airway-face mask versus laryngeal airway (LMA).Methods Seventy-two children,scheduled for elective high ligation indirect inguinal hernia,were randomly divided into 2 groups (n =36 each):nasopharyngeal group (group M) and LMA L).Propofol 1.0 mg/kg fentanyl 2.0μg/kg were injected intravenously.The...
Abstract The activation of glycolysis, particularly in the context reprogrammed energy metabolism, is increasingly recognized as a significant characteristic cancer. However, precise mechanisms by which glycolysis promoted metastatic gastric cancer cells under normal oxygen conditions remain poorly understood. MicroRNAs (miRNAs) play crucial role development malignant phenotypes Nevertheless, our understanding specific involvement miRNAs hypoxia-induced metabolic shifts and subsequent...
Objective To investigate the effects of pregabalin on postoperative analgesia in patients with lower abdominal surgery. Methods The aged 19-70,ASA Ⅰ -Ⅱ,scheduled for surgery were randomly divided into 2 groups (n=15):Group P (pregabalin) and Group C(control).The C orally took (75 mg) or self-made flour capsule 30 min prior to general anesthesia,respectively.General anesthesia was routinely induced maintained remifentanil,propofol muscle relaxant.Patient-controlled intravenous (PCIA) used...
Objective To evaluate the efficacy and safety of supraglottic jet ventilation modified laryngeal mask airway during painless fiberbronchoscopy. Methods Eighty patients undergoing fiberbronchoscopy were randomly divided into 2 groups(n=40), receiving (J group) (L group), respectively. The outcomes procedures recorded, including success rate first tubing insertion, time spent in successful positioning tube, stability related complications. Furthermore, MAP, HR, SpO2 PETCO2 monitored...
Objective To evaluate the efficacy of WEI NASAL JET for supraglottic ventilation before tracheal intubation in patients with tooth loss. Methods Sixty both sexes loss (more than 8 teeth missing), aged 67-83 yr, American Society Anesthesiologists physical statusⅠ-Ⅲ, Mallampati classificationⅠ-Ⅲ, body mass index 18-25 kg/m2, undergoing surgery general anesthesia, were divided into 2 groups (n=30 each) using a random number table method: group (S group) and mask (M group). After end...