A5087653097- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Clostridium difficile and Clostridium perfringens research
- SARS-CoV-2 detection and testing
- Liver Disease and Transplantation
- SARS-CoV-2 and COVID-19 Research
- Infective Endocarditis Diagnosis and Management
- Diet and metabolism studies
- Clinical Nutrition and Gastroenterology
- Liver Disease Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Oral health in cancer treatment
- Geriatric Care and Nursing Homes
- Endometrial and Cervical Cancer Treatments
- Nutrition and Health in Aging
- Stoma care and complications
- Mycobacterium research and diagnosis
- Bacterial Identification and Susceptibility Testing
- Genital Health and Disease
- Ovarian cancer diagnosis and treatment
- Legionella and Acanthamoeba research
- Pneumonia and Respiratory Infections
- Neutropenia and Cancer Infections
- COVID-19 diagnosis using AI
University of Chicago
2020-2025
Evanston Hospital
2024
University of Chicago Medical Center
2022
Anna Needs Neuroblastoma Answers
2022
Massachusetts General Hospital
2022
University of Michigan
2022
Tallaght University Hospital
1995-2003
Abstract Background Loss of a diverse intestinal microbiome, particularly through the depletion anaerobic bacteria, is associated with poor outcomes in people undergoing treatment for leukemia. We present preliminary results from pilot, prospective observational study characterizing longitudinal changes fecal microbiome and metabolome patients intensive chemotherapy newly diagnosed acute myeloid leukemia (AML). Methods recruited 10 AML who were hospitalized chemotherapy. The subjects...
ABSTRACT The BioFire Joint Infection Panel (JI panel) is a newly FDA-approved multiplex PCR assay for detection of common bone and joint pathogens with 39 targets which include select Gram-positive Gram-negative bacteria, yeast, antimicrobial resistance genes. We evaluated the performance JI panel in detecting infections our patient population. Sixty-three frozen, residual fluid specimens were retrospectively tested using panel. An additional 104 de-identified prospectively within 1 week...
Abstract As the Coronavirus 2019 (COVID-19) pandemic evolves, development of immunoassays to help determine exposure and potentially predict immunity has become a pressing priority. In this report we present performance EUROIMMUN enzyme-linked immunosorbent assay (ELISA) for semi-quantitative detection IgA IgG antibodies in serum plasma samples using recombinant S1 domain SARS-CoV-2 spike protein as antigen. Specimens from patients, with without COVID-19 infection, were tested at University...
Emerging evidence is revealing the impact of gut microbiome on hematopoietic and solid organ transplantation. Prior studies postulate that this influence mediated by bioactive metabolites produced gut-dwelling commensal bacteria. However, microbial metabolite production has not previously been measured among heart transplant (HT) recipients.
We report a fatal case of Legionella feeleii endocarditis in post-lung transplant patient. The diagnosis was delayed, as routine microbiological testing nonrespiratory specimens does not account for extrapulmonary Legionella, and urine antigen only reliably detects pneumophila serogroup 1. This also illustrates the utility molecular sequencing blood culture-negative endocarditis.
Abstract Background The gut microbiota plays a critical role in health and its disruption can impact clinical outcomes variety of circumstances, including graft-versus-host disease following hematopoietic stem cell transplantation, Clostridioides difficile infections, liver disease. Metagenomic metabolomic analyses fecal material is frequently performed the research setting; however, evaluation not yet incorporated into routine patient care. One barrier to implementation lack...
ABSTRACT The intestinal microbiome is composed of myriad microbial species that produce metabolites impact host health. While loss bacterial and beneficial from the fecal associated with development a range diseases medical complications, there are currently no diagnostic tests rapidly identify individuals deficiencies. Reduced concentrations butyrate deoxycholic acid adverse clinical outcomes result subset health-associated species. We present rapid test based on 3-nitrophenylhydrazine...
ABSTRACT Progression of chronic liver diseases is precipitated by hepatocyte loss, inflammation and fibrosis. This process results in the loss critical hepatic functions, increasing morbidity risk infection. Medical interventions that treat complications failure, including antibiotic administration for systemic infections, impact gut microbiome composition metabolite production. Using a multi-omics approach on 850 fecal samples from 263 patients with acute or disease, we demonstrate...
ABSTRACT Background Liver transplantation (LT) is associated with postoperative infections caused by antibiotic-resistant bacterial pathogens that reside in the intestine. An intact intestinal microbiome suppresses expansion of enteric pathogens, however patients severe liver disease often have reduced diversity and increased density Enterococcus Enterobacterales species. (1–4) Experimental models demonstrated metabolites produced microbiome, including short chain fatty acids (SCFAs),...
Most low-grade, early-stage endometrial endometrioid carcinomas (EEC) have an excellent prognosis; however, recurrences occur in a small subset with several studies reporting increase CTNNB1 exon 3 mutations this population. Herein we evaluated 10 recurrent low-grade (FIGO 1 or 2), IA) EECs matched to nonrecurrent further characterize their clinicopathologic features and molecular phenotype. Cases were controls based on size, grade, depth of invasion. All tumors for specific parameters...
Screening for Neisseria gonorrhoeae and Chlamydia trachomatis is recommended individuals at high-risk sexually transmitted infections (STIs), while the role of Mycoplasma genitalium screening still unclear. We evaluated whether specimen pooling an effective alternative infection testing during resource shortages.This 2-year prospective study enrolled 135 asymptomatic patients from a community outreach site who identified as men have sex with men. Oropharyngeal, urine, and/or rectal swab...
Journal Article The Elderly and Hospital-Acquired Diarrhoea: A High-Risk Group Get access L Kyne, MRCPI, MRCPI Age-Related Health Care & Dept. of Microbiology, Meath HospitalDublin 8, Ireland Search for other works by this author on: Oxford Academic PubMed Google Scholar Moran, MB, MB C Keane, MD, MD D O'Neill, Age Ageing, Volume 24, Issue suppl_2, 1995, Pages P17-c–P17, https://doi.org/10.1093/ageing/24.suppl_2.P17-c Published: 01 September 1995