A5067791758- Plant Reproductive Biology
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Plant and animal studies
- Plant Molecular Biology Research
- Bariatric Surgery and Outcomes
- Global Health and Surgery
- Glioma Diagnosis and Treatment
- Global Health Workforce Issues
- Gallbladder and Bile Duct Disorders
- Gastroesophageal reflux and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Phytase and its Applications
- Biotin and Related Studies
- Ubiquitin and proteasome pathways
- Botanical Research and Chemistry
- Abdominal Surgery and Complications
- Angiogenesis and VEGF in Cancer
- Congenital Diaphragmatic Hernia Studies
- Restraint-Related Deaths
- Phytochemical Studies and Bioactivities
- Pediatric Urology and Nephrology Studies
- Photosynthetic Processes and Mechanisms
- Soybean genetics and cultivation
- Sarcoma Diagnosis and Treatment
University of Illinois Chicago
2021-2024
University of Illinois Hospital & Health Sciences System
2021-2024
Mount Sinai Hospital
2023
King's College London
2019
American College of Surgeons
2019
Canadian Anesthesiologists' Society
2019
Royal College of Surgeons of England
2019
Shriners Hospitals for Children - Northern California
2019
Rady Children's Hospital-San Diego
2019
University of California, San Diego
2019
Dysfunctional tumor vessels can be a significant barrier to effective cancer therapy. However, increasing evidence suggests that vascular endothelial growth factor (VEGF) inhibition effect transient "normalization" of the vasculature, thereby improving perfusion and, consequently, delivery systemic chemotherapy. We sought examine temporal changes in function response anti-VEGF antibody, bevacizumab.Established orthotopic neuroblastoma xenografts treated with bevacizumab were evaluated at...
We characterized the structure, organization, and expression of genes that encode soybean glycinins, a family storage proteins synthesized exclusively in seeds during embryogenesis. Five predominant glycinin subunits found soybeans, they have each been cloned, sequenced, compared. The five diverged into two subfamilies are designated as Group-I Group-II genes. Each gene contains four exons three introns like related other legumes. Two identified "glycinin-related" because hybridize weakly...
Petunia hybrida is a popular bedding plant that has long history as genetic model system. We report the whole-genome sequencing and assembly of inbred derivatives its two wild parents, P. axillaris N inflata S6. The assemblies include 91.3% 90.2% coverage their diploid genomes (1.4 Gb; 2n = 14) containing 32,928 36,697 protein-coding genes, respectively. reveal lineage experienced at least rounds hexaploidization: older gamma event, which shared with most Eudicots, more recent Solanaceae...
We investigated the structure and expression of three S-alleles Petunia hybrida in self-incompatible varieties a pseudo-self-compatible line which self-incompatibility response is defective. Comparison derived amino acid sequences from different gametophytic revealed pattern sequence conservation variability that was highly nonrandom. In varieties, petunia S-locus mRNA accumulates preferentially styles during transition bud self-compatibility to self-incompatibility. S-Allele homologous...
The self-incompatibility (SI) response occurs widely in flowering plants as a means of preventing self-fertilization. In these self/non-self discrimination systems, plant pistils reject self or genetically related pollen. the Solanaceae, Plantaginaceae and Rosaceae, pistil-secreted S-RNases enter pollen tube function cytotoxins to specifically arrest self-pollen growth. Recent studies have revealed that S-locus F-box (SLF) protein controls expression SI families. However, precise role SLF...
Illumination (22,000 lumens per meter(2)) of etiolated maize plants for 80 hours brings about a 5-fold increase in phosphoenolpyruvate carboxylase activity unit protein. An protein and incorporation [(35)S]methionine into the occurs simultaneously with increase. In green plants, level enzyme is dependent on intensity light during growth. These results are consistent conclusion that from light-stimulated de novo synthesis phosphoenolypyruvate
Polyadenylated RNA has been isolated from maize leaves at various times during greening of etiolated seedlings and used to prime the wheat germ cell-free translation system. Levels translatable messenger for phosphoenolpyruvate carboxylase increase with length illumination period. The pattern in mRNA enzyme is similar that protein previously observed intact tissues. Phosphoenolpyruvate synthesized vivo migrates as a doublet band on gradient sodium dodecyl sulfate-polyacrylamide gels. A seen...
Different robotic systems have been used widely in human surgery since 2000, but pediatric patients require some features that are lacking the most frequently systems.The Senhance® system is a safe and an effective device for use infants children has advantages over other systems.All between 0 18 years of age whose was amenable to laparoscopy were offered enrollment this IRB-approved study. We assessed feasibility, ease safety using platform including: set-up time, operative conversions,...
Abstract Self‐incompatibility is a cell‐cell recognition system in higher plants that based on the ability of pistil to discriminate “self‐pollen from “non‐self"‐pollen. In simplest systems, this response controlled by single locus — S‐locus with multiple alleles. Pollination pollen bearing an S‐allele factor identical expressed host plant stigma or style results rejection “self"‐pollen. Most studies molecular genetics self‐incompatibility are summarized review have had as their goal...
The nucleotide sequence of the Gy.glycinin storage protein gene is shown below.It was obtained by sequencing both strands contained in lambda DA28-30, a clone isolated from genomic library prepared using leaf DNA soybean variety Dare.The transcribed region bold type and first base this considered +1.Potential regulatory sequences are underlined type.These include CACA (-428) CATGCAT elements (-109 -253), lequmin box (-90 to -117), TATA (-32) polyadenylation signals (2498 2612).This discussed...
Abstract Although temozolomide has shown clinical activity against neuroblastoma, this is likely limited by the DNA repair enzyme O6-methylguanine methyltransferase (MGMT). We hypothesized that IFN-β could sensitize neuroblastoma cells to cytotoxic effects of through its ability down-regulate MGMT expression. In vitro proliferation three cell lines treated with and alone or in combination was examined. Antitumor assessed both localized disseminated xenografts using single-agent therapy,...