A5049802616- Blood transfusion and management
- Immune Cell Function and Interaction
- Blood properties and coagulation
- T-cell and B-cell Immunology
- Electrospun Nanofibers in Biomedical Applications
- Angiogenesis and VEGF in Cancer
- Optical Imaging and Spectroscopy Techniques
- Immunotherapy and Immune Responses
- Hemostasis and retained surgical items
- Transgenic Plants and Applications
- Muscle metabolism and nutrition
- Platelet Disorders and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Muscle Physiology and Disorders
- Analytical Methods in Pharmaceuticals
- Chemical Synthesis and Reactions
- High Altitude and Hypoxia
- Protein purification and stability
- Inorganic and Organometallic Chemistry
- Mesenchymal stem cell research
- Non-Invasive Vital Sign Monitoring
- Biochemical and Structural Characterization
- Bacteriophages and microbial interactions
- Periodontal Regeneration and Treatments
École Polytechnique Fédérale de Lausanne
2010-2017
Illinois Institute of Technology
2006-2008
Significance Inducing the growth of new blood vessels by specific factors is an attractive strategy to restore flow in ischemic tissues. Vascular endothelial factor (VEGF) master regulator angiogenesis, yet clinical trials VEGF gene delivery failed. Major challenges include need control tissue distribution dose and duration expression. Here, we developed a highly tunable fibrin-based platform precisely protein Optimized fibrin-bound ensured normal, stable, functional angiogenesis improved...
Humoral immune tolerance to the therapeutic enzyme E. coli l -asparaginase was induced by engineering for in vivo erythrocyte binding.
Although most current treatments for autoimmunity involve broad immunosuppression, recent efforts have aimed to suppress T cells in an antigen-specific manner minimize risk of infection. One such effort is through targeting antigen the apoptotic pathway increase presentation interest a tolerogenic context. Erythrocytes present rational candidate target because their high rate eryptosis, which facilitates continual uptake by antigen-presenting spleen. Here, we develop approach that binds...
Aprotinin is a broad-spectrum serine protease inhibitor used in the clinic as an anti-fibrinolytic agent fibrin-based tissue sealants. However, upon re-exposure, some patients suffer from hypersensitivity immune reactions likely related to bovine origin of aprotinin. Here, we aimed develop human-derived substitute Based on sequence homology analyses, identified Kunitz-type (KPI) domain human amyloid-β A4 precursor protein being potential candidate. While KPI has lower intrinsic activity than...
Fibrin has long been used clinically for hemostasis and sealing extensively characterized as a biomaterial. Yet, in terms of harnessing its potential use tissue regeneration, there remains wide gap between vitro experimentation clinical application. Important factors contributing to this disjunction are rapid resorption vivo, handling capability, therapeutic robustness. This thesis addresses some the shortcomings associated with fibrin regeneration by offering feasible solutions improve...