Abstract Objective To examine the potential value of maternal serum concentration placental protein 13 (PP13) at 11–13 weeks' gestation in screening for preeclampsia (PE). Methods Serum PP13, PAPP‐A and uterine artery pulsatility index (PI) were determined a case–control study 208 cases that developed PE including 48 required delivery before 34 weeks (early‐PE) 416 unaffected controls. Results PP13 levels, expressed as multiples median (MoM) group, significantly reduced early‐PE (0.83 MoM)...

The concentrations of various trace elements in amniotic fluid (AF) change over the course pregnancy, with gestational age and fetus growth. aim present study was to evaluate selected essential toxic AF their relations maternal fetal parameters. carried out 39 pregnant women, aged 34.6 ± 4.7 years, between weeks 16 26 gestation. Amniotic samples were obtained during standard procedure amniocentesis high-risk patients for chromosomal abnormalities. An inductively coupled plasma mass...

Alpha-fetoprotein (AFP) is a serum protein, which characteristic of the fetal development period and well-known oncological marker. The predominance AFP among proteins common in life, whereas after birthing its functions are gradually taken over by albumins. An understanding mechanism transfer between fetus mother has led to screening tests for identifying neural tube defects Down's syndrome. Currently, knowledge on patophysiology possible importance perinatology medicine extends far beyond...

Preterm birth is defined as delivery before 37 completed weeks of pregnancy, and it the leading cause neonatal morbidity mortality. Oxidative stress recognized an important factor in pathogenesis premature labor. We conducted this analysis to investigate safety administration tocolytic drug Atosiban-a reversible, competitive antagonist oxytocin receptor treatment preterm its impact on level oxidative pregnant women after 48 hours treatment. This prospective study was between March 2016...

The objective of this study was to determine the concentration and reference ranges essential toxic elements in amniotic fluid (AF) maternal serum (MS) at birth. This conducted among 175 healthy pregnant Caucasian European women aged 18–42. AF blood samples were collected during delivery. An inductively coupled plasma mass spectrometry (ICP-MS) technique used levels Mg, Co, Cu, Zn, Sr, Cd, Ba, Pb, U, Ca, Cr, Al, Mn, V, Fe, As, Se Sb MS. range values calculated for all analyzed AF. mean...

Alpha-fetoprotein (AFP) is one of the biochemical components triple (T-3) and quadruple (T-4) test used so far in prenatal screening mainly for trisomy 21 (T21) neural tube defects (NTDs). Based on many years experience data collected during these studies, a variety factors have been identified that can affect pregnant woman's serum AFP level, thus risk assessment defects. These include both unaccounted purely medical (e.g., from baseline information about patient, assisted reproduction...

Congenital birth defects may result in a critical condition affecting the baby, including severe fetal/neonatal handicap and mortality. Several studies have shown that genetic, nutritional, environmental factors an impact on fetal development neonatal health. The relevance of essential toxic elements has not yet been fully investigated, results recent research indicate these be crucial assessment risk malformations neonates. We determined association between level folate maternal serum (MS)...

Although simultaneous supplementation of iron and folic acid is justified, the potential interactions between these micronutrients other elements are poorly known. In this study, we aimed to investigate effect on levels selected essential toxic in serum micronutrient-deficient young women. A total 40 women participated study were divided into two groups: group (n = 23) (with folate deficiency) control 17). The received supplements for 3 months. Blood samples collected at baseline after...

Prenatal nutrition plays a crucial role in maternal and child health. This study aims to compare nutrient intake its adequacy recommendations among pregnant women Spain Poland. The ECLIPSES utilized self-administered food frequency questionnaire, while the PREDISH Poland employed 3-day interview method. We assessed energy against recommended dietary allowances. analysis included 583 participants first trimester 465 third from both countries. Our findings revealed insufficient of iron,...

Folate is required for fetal, placental and maternal tissue growth during pregnancy. A decline in circulating folate concentrations an increase total homocysteine (a non-specific indicator of deficiency) have been observed with the progression However, role third trimester pregnancy not clear status late has so far widely analyzed. The main aim this retrospective cross-sectional study was to determine amniotic fluid umbilical cord blood serum derived delivery.This conducted on 175 pregnant...

Mycotoxin exposure assessments through biomonitoring studies, based on the analysis of amniotic fluid, provides useful information about potential mothers and fetuses to ubiquitous toxic metabolites that are routinely found in food environment. In this study, fluid samples (n = 86) were collected via abdominal amniocentesis at 15-22 weeks gestation from pregnant women with a high risk chromosomal anomalies or genetic fetal defects detected during 1st trimester prenatal screening. These...

The present study aimed to investigate the relationship between concentrations of essential and toxic elements in amniotic fluid (AF) fetal chromosomal abnormalities pregnant women. A total 156 white Polish women aged 20 43 years screened detect high risk for defects first trimester were included study. AF samples collected from these during routine diagnostic treatment procedures at mid-gestation (15-22 weeks their pregnancies). various minerals determined by inductively coupled plasma mass...