A5108053944- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- Plant-Microbe Interactions and Immunity
- Aquaculture disease management and microbiota
- Whipple's Disease and Interleukins
- Liver Disease and Transplantation
- Plant biochemistry and biosynthesis
- Natural product bioactivities and synthesis
- Plant tissue culture and regeneration
- Cytokine Signaling Pathways and Interactions
- Genetic diversity and population structure
- Mycorrhizal Fungi and Plant Interactions
- Ginseng Biological Effects and Applications
- Viral Infections and Immunology Research
- Nuclear Receptors and Signaling
- Chemokine receptors and signaling
- Plant Molecular Biology Research
- Liver Disease Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Botanical Studies and Applications
- Lipid metabolism and biosynthesis
- Plant Pathogenic Bacteria Studies
- Genetic Mapping and Diversity in Plants and Animals
- Soil Carbon and Nitrogen Dynamics
- Mitochondrial Function and Pathology
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Anhui Institute of Optics and Fine Mechanics
2024
Guizhou Academy of Agricultural Sciences
2022-2024
Institute of Pomology
2021-2023
Nanjing Agricultural University
2006-2022
Guizhou Electric Power Design and Research Institute
2022
Huazhong Agricultural University
2020-2022
Linyi People's Hospital
2019
Peking University
2019
Peking University People's Hospital
2019
Ginseng, which contains ginsenosides as bioactive compounds, has been regarded an important traditional medicine for several millennia. However, the genetic background of ginseng remains poorly understood, partly because plant's large and complex genome composition. We report entire sequence Panax using next-generation sequencing. The 3.5-Gb nucleotide more than 60% repeats encodes 42 006 predicted genes. Twenty-two transcriptome datasets mass spectrometry images roots were adopted to...
Chitin is a major component of fungal cell wall and synthesized by chitin synthases (Chs). Plant pathogenic fungi normally have multiple synthase genes. To determine their roles in development pathogenesis, we functionally characterized all seven CHS genes Magnaporthe oryzae. Three them, CHS1, CHS6, CHS7, were found to be important for plant infection. While the chs6 mutant was non-pathogenic, chs1 chs7 mutants significantly reduced virulence. CHS1 plays specific role conidiogenesis, an...
Abstract Perilla is a young allotetraploid Lamiaceae species widely used in East Asia as herb and oil plant. Here, we report the high-quality, chromosome-scale genomes of tetraploid ( frutescens ) AA diploid progenitor citriodora ). Comparative analyses suggest post Neolithic allotetraploidization within 10,000 years, nucleotide mutation 10% more than diploid, both which are dominated by G:C → A:T transitions. Incipient diploidization characterized balanced swaps homeologous segments,...
AbstractMonocyte chemoattractant protein 1 (MCP-1) is a member of the chemokine family proinflammatory cytokines, all which share high degree amino acid sequence similarity. Aberrant expression chemo-kines occurs in variety diseases that have an inflammatory component, such as atherosclerosis. Although structural analyses indicate chemokines form homodimers, there controversy about whether dimerization necessary for activity. To address this question MCP-1, we obtained evidence four steps....
Summary Andrographis paniculata is a herbaceous dicot plant widely used for its anti‐inflammatory and anti‐viral properties across distribution in China, India other Southeast Asian countries. A. was as crucial therapeutic treatment during the influenza epidemic of 1919 India, still infectious disease China. produces large quantities diterpenoid lactones andrographolide neoandrographolide, their analogs, which are touted to be next generation natural medicines lung diseases, hepatitis,...
This study investigates the role of abscisic acid (ABA) in bolstering drought resistance plants, employing “Panjiang Sophora viciifolia” as subject. A simulated scenario was created using polyethylene glycol (PEG-6000) to examine impact varying intensities (0%, 5%, 20% PEG) and ABA concentrations (0, 10, 50, 100, 200 mg·L−1) on germination physiological parameters viciifolia. The results showed that absence ABA, rate (GR), potential (GP), index (GI) S. viciifolia seeds initially increased...
Meliaceous plants such as Azadirachta indica (neem) and Melia azedarach (chinaberry) contain large amounts of limonoids with unique anti-insect activities. However, genes responsible for downstream modifications are not well known. Here, we improve the genome assemblies neem chinaberry to telomere-to-telomere (T2T) level. Allopatric speciation two is confirmed by lineage-specific inversion chromosome 12 in lineage. We further identify BAHD-acetyltransferases (ATs) (MaAT8824 MaAT1704) that...
IL-16 is synthesized as a precursor molecule of 68 kDa (pro-IL-16) that processed by caspase-3, member the IL-1 converting enzyme (ICE) family. This cleavage results in 13-kDa carboxy terminal peptide, which constitutes bioactive secreted form IL-16. We have previously reported constitutive mRNA expression and pro-IL-16 protein CD4+ CD8+ T cells. Although present unstimulated cells, there no Along these lines, cells contain active caspase-3. In current studies we investigated regulation...
Abstract The genetic diversity of germplasm is critical for exploring and phenotypic resources has important implications crop-breeding sustainability improvement. However, little known about the factors that shape maintain diversity. Here, we assembled a high-quality chromosome-level reference Chinese common apricot ‘Yinxiangbai’, resequenced 180 accessions cover four major ecogeographical groups in China other from occidental countries. We concluded Chinese-cultivated germplasms possessed...
Seed endophytes in maize, which facilitate the transmission of microorganisms from one plant generation to next, may play a crucial role protection and growth promotion. This study aimed investigate effects various maize varieties on communities endophytic bacteria seeds germinating roots. utilized Illumina high-throughput sequencing technology examine structural diversity differences bacterial within seed (BY1507), silage (QQ446), wild (Teosinte) both The results showed that 416 genera were...
Acute radiation-induced esophagitis (ARIE) is among the most serious form of toxicities associated with definitive radiotherapy or chemoradiotherapy used for treatment patients esophageal cancer. Our preliminary phase I and II trials lung cancer who received indicated epigallocatechin-3-gallate (EGCG) as a promising therapeutic option against ARIE. Therefore, we conducted prospective study to validate efficacy safety EGCG in The Shandong Cancer Hospital Institute China were enrolled present...
Microbes, especially abundant microbes in bulk soils, form multiple ecosystem functions, which is relatively well studied. However, the role of rhizosphere microbes, rare taxa vs. regulating element circling, multifunctionality, aboveground net primary productivity (ANPP) and trade-offs functions remains largely unknown. Here, we compared structure function soil bacterial fungal subcommunities (locally rare, locally abundant, regionally entire), Zea mays Sophora davidii sole Z. mays/S....
Interleukin-16 (IL-16) is a pleiotropic cytokine that functions as chemoattractant factor, modulator of T cell activation, and an inhibitor human immunodeficiency virus (HIV) replication. These diverse are exclusively attributed to the secreted C-terminal peptide 121 amino acids (mature IL-16), which cleaved from precursor protein (pro-IL-16) by caspase-3. Human pro-IL-16 comprised 631 with three PDZ domains, one present in mature IL-16. No cellular localization or biologic have been...
Abstract Chinese plum ( Prunus salicina L.), also known as Japanese plum, is gaining importance because of its extensive genetic diversity and nutritional attributes that are beneficial for human health. Single-nucleotide polymorphisms (SNPs) the most abundant form genomic widely used in population genetics research. In this study, we constructed high-quality SNPs through whole-genome resequencing 67 accessions with a depth ~20× to evaluate genome-level structure. Phylogenetic analysis,...
The retinoblastoma protein (Rb) plays a pivotal role in regulating cell proliferation and apoptosis. Nutlin-3, small molecule MDM2 antagonist blocking interaction between p53, activates p53 resulting growth arrest or apoptosis various cancer cells. However, the molecular basis for different cellular responses upon nutlin-3 treatment is not fully understood. In this study, we show that dramatic increase expression marked reduction total Rb levels. Interestingly, reduces levels of...
The objective is to investigate the effect of high mobility group box-1 (HMGB1) on lipid deposition in γ-interferon (IFN-γ)-stimulated mouse mesangial cell line (MMC) and determine whether Janus kinase 2 signal transducer activator transcription 1 (JAK2/STAT1) signaling pathway plays an important role this process. We employed a control group, IFN-γ stimulation + AG490 (JAK2 inhibitor) group. RNA interference aimed at sterol regulatory element-binding protein-1 (SREBP-1) or HMGB1 was used...
Cyprinid herpesvirus 2 (CyHV-2, species 2) causes severe mortality in ornamental goldfish, crucian carp (Carassius auratus), and gibel gibelio). It has been shown that the genomic DNA of CyHV-2 could be detected subclinical fish, which implied establish persistent infection. In this study, latency was investigated survival fish after primary multiple tissues acute infection samples; however, detection significantly reduced recovered from on day 300 postinfection. No active viral gene...
Abstract Three amicarthiazol‐resistant mutants (Xuv10, Xuv20 and Xuv40) were obtained by UV induction used in this study. Minimal inhibition concentrations (MICs) of amicarthiazol against the growth wild‐type isolate 400 100 µg ml −1 respectively. Inhibition succinate dehydrogenase (SDH) activities Xanthomonas campestris pv. citri (Hasse) Dye (Xcc) three resistant derived from assayed using triphenyltetrazolium chloride (TTC). The SDH these significantly lower than that Xcc. complete...
The chloroplast is a self-independent organelle and contains its own transcription translation systems. establishment of genetic systems vital for normal plant growth development. We isolated rice zebra leaf 16 (zl16) mutant derived from cultivar 9311. zl16 showed chlorotic abnormalities in the transverse sectors young leaves seedlings. use transmission electron microscopy (TEM) demonstrated that dramatic defects occurred variegated during early development chloroplast. Map-based cloning...