A5032427061- Ginseng Biological Effects and Applications
- Genomics and Phylogenetic Studies
- Phytochemistry and biological activity of medicinal plants
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Chromatography in Natural Products
- Plant and Fungal Species Descriptions
- Plant Pathogens and Fungal Diseases
- Plant Disease Resistance and Genetics
- Plant tissue culture and regeneration
- Phytochemicals and Antioxidant Activities
- Plant-Microbe Interactions and Immunity
- Plant biochemistry and biosynthesis
- Plant Physiology and Cultivation Studies
- Ginger and Zingiberaceae research
- Biological and pharmacological studies of plants
- Identification and Quantification in Food
- Polysaccharides and Plant Cell Walls
- Amphibian and Reptile Biology
- Biochemical and Structural Characterization
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Fungal Biology and Applications
- Fungal Plant Pathogen Control
Gansu Provincial Hospital
2022-2025
Guangzhou University of Chinese Medicine
2017-2025
Guangdong Provincial Hospital of Traditional Chinese Medicine
2017-2024
National Medical Products Administration
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2019
China Agricultural University
2014-2019
China Academy of Chinese Medical Sciences
2017-2018
Institute of Chinese Materia Medica
2017
Guangdong Ocean University
2014-2015
Ginseng, which contains ginsenosides as bioactive compounds, has been regarded an important traditional medicine for several millennia. However, the genetic background of ginseng remains poorly understood, partly because plant's large and complex genome composition. We report entire sequence Panax using next-generation sequencing. The 3.5-Gb nucleotide more than 60% repeats encodes 42 006 predicted genes. Twenty-two transcriptome datasets mass spectrometry images roots were adopted to...
The cultivation of Panax plants is hindered by replanting problems, which may be caused plant-driven changes in the soil microbial community. Inoculation with antagonists efficiently alleviate issues. Through high-throughput sequencing, this study revealed that bacterial diversity decreased, whereas fungal increased, rhizosphere soils adult ginseng at root growth stage under different ages. Few community, such as Luteolibacter, Cytophagaceae, Luteibacter, Sphingomonas, Sphingomonadaceae, and...
Background: This study aimed to investigate the role of ROS/MAPK signaling pathways and effects baicalin in LPS-induced inflammatory responses mice porcine intestinal epithelial cells (IPEC-J2). Methods: In vivo, 18 male C57BL/6J were randomly divided into three groups (n = 6): control, LPS (3.5 mg/kg administered intraperitoneally [ip] on day 7), (200 orally for 7 days, with ip 7). On 8, sacrificed, jejunal tissues collected H&E staining. ROS levels serum cytokine protein expressions...
Ginseng (Panax ginseng C.A. Meyer) is one of the best-selling herbal medicines, with ginsenosides as its main pharmacologically active constituents. Although extensive chemical and pharmaceutical studies these compounds have been performed, genome-wide basic helix-loop-helix (bHLH) transcription factors are still limited. The bHLH factor family largest families found in eukaryotic organisms, proteins involved a myriad regulatory processes. In our study, 169 genes were identified genome P....
Panax quinquefolius and notoginseng are widely used well known for their pharmacological effects. As main components, saponins have different distribution patterns in the root tissues of plants.In this study, representative ginsenosides were detected quantified by desorption electrospray ionization mass spectrometry high-performance liquid chromatography analysis to demonstrate saponin P. notoginseng, metabolite profiles analyzed metabolomes obtain biomarkers tissues. Finally, transcriptome...
Astragalus membranaceus var. mongholicus (AMM), a member of the Leguminosae, is one most important medicinal plants worldwide. The dried roots AMM have wide range pharmacological effects and are traditional Chinese medicine. Here, we report first chromosome-level reference genome AMM, comprising nine pseudochromosomes with total size 1.47 Gb 27 868 protein-encoding genes. Comparative genomic analysis reveals that has not experienced an independent whole-genome duplication (WGD) event after...
Chloroplast genomes for 3 Bidens plants endemic to China (Bidens bipinnata Linn., pilosa and alba var. radiata) have been sequenced, assembled annotated in this study distinguish their molecular characterization phylogenetic relationships. The chloroplast are typical quadripartite structure with two inverted repeat regions separating a large single copy region small region, ranged from 151,599 154,478 bp length. Similar number of SSRs long repeats were found Bidens, wherein mononucleotide...
Southern Chinese Medicine (SCM) is an important sect of Traditional (TCM) with its own special cultural style. Species identification essential for TCM quality control because authentic herbs are possibly substituted adulterants that would threaten the health public or even cause death. Here, we provided first local reference DNA barcode library based on second internal transcribed spacer (ITS2) molecular SCM. A total 1512 specimens southern representing 359 species were collected under...
CRP (Citri Reticulatae Pericarpium), a famous traditional Chinese medicine, has also been extensively used in foods and condiments dietary practice for centuries. According to the Pharmacopeia (2015 edition) it contains two subtypes, Guangchenpi (GCP) Chenpi (CP). GCP exclusively originates from pericarp of Citrus reticulata 'Chachi' cultivar it's generally believed that superior qualities compared with other main cultivars In present study, an integrated approach combining LC-QTOF MS-based...
Species in genus Amomum always have important medicinal and economic values. Classification of using morphological characters has long been a challenge because they exhibit high similarity. The main goals this study were to mine genetic markers from cp genomes for species identification discover their evolutionary history through comparative analysis.Three villosum, maximum longipetiolatum sequenced annotated the complete chloroplast (cp) genomes, A. first reported. Three exhibited typical...
Gastric cancer (GC) is one of the most common tumors; reasons for its poor prognosis that GC cells can resist normal cell death process and therefore develop distant metastasis. Cuproptosis a novel type limited number studies have been conducted on relationship between cuproptosis-related genes (CRGs) in GC. The purpose present study was to establish prognostic model CRGs provide directions diagnosis treatment Transcriptome clinical data patients with were collected from Cancer Genome Atlas...
Herbgenomics provides a global platform to explore the genetics and biology of herbs on genome level. Panax ginseng C.A. Meyer is an important medicinal plant with numerous pharmaceutical effects. Previous reports mainly discussed transcriptome at organ However, based mass spectrometry imaging analyses, ginsenosides varied among different tissues. In this work, root was separated into three tissues-periderm, cortex stele-each for five duplicates. The chemical analysis were conducted...
Herb genomics and comparative provide a global platform to explore the genetics biology of herbs at genome level. Panax ginseng C.A. Meyer is an important medicinal plant for variety bioactive chemical compounds which biosynthesis may involve transport wide range substrates mediated by oligopeptide transporters (OPT). However, information about OPT family in kingdom still limited. Only 17 18 genes have been characterized Oryza sativa Arabidopsisthaliana, respectively. Additionally, few...
The many-banded krait, Bungarus multicinctus, has been recorded as the animal resource of JinQianBaiHuaShe in Chinese Pharmacopoeia. Characterization its venoms classified chief phyla modern neurotoxins. However, evolutionary origin and diversification neurotoxins well biosynthesis active compounds remain largely unknown due to lack high-quality genome. Here, we present 1.58 Gbp genome B. multicinctus assembled into 18 chromosomes with contig/scaffold N50 7.53 Mbp/149.8 Mbp. Major...
Generally, chloroplast genomes of angiosperms are always highly conserved but carry a certain number variation among species. In this study, 13 species from Datureae tribe that importance both in ornamental gardening and medicinal usage were studied. addition, seven together with two Solanaceae retrieved the National Center for Biotechnology Information (NCBI) integrated into study. The ranged size 154,686 to 155,979 155,497 155,919 bp Datura Brugmansia, respectively. As total 128 132 genes...
Introduction: The root of Reynoutria multiflora (Thunb.) Moldenke (RM) has been used widely in formulations herbal medicines China for centuries. Raw R. (RRM) should be processed before use to reduce toxicity and increase efficacy. However, detailed regulation the processing endpoint is lacking, duration can vary considerably. We conducted in-depth research on stilbene glycosides RM at different times. Previously, we discovered that 219 changed markedly quantity content. Therefore, proposed...
Bruguiera gymnorrhiza (L.) Savigny is an important mangrove tree species that grows in the intertidal regions of tropical and subtropical coastlines. In a survey conducted March 2014, leaf spot disease on this plant was observed Sea View Promenade Zhanjiang, Guangdong Province, China. Symptoms leaves initially appeared as small circular to irregular, dark brown, necrotic, sunken spots with average diameter 4 7 mm. The gradually enlarged size, becoming or remained concentric rings zones....
Ginsenosides have poor oral bioavailability and undergo rapid biological transformation in the complex gastrointestinal environment. Most studies on metabolism of ginsenosides focused gut bacteria, yet gastric juice remains a nonnegligible factor. Metabolic profiles ginsenoside monomers formed artificial were separately investigated qualitatively identified using ultra-high-pressure liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap MSn ). A...
Abstract Background Bungarus multicinctus , from which a classical Chinese medicine is produced, known as the most venomous land snake in world, but chromatin organization and transcription factor activity during venom replenishment progress have not been explored yet. This study aimed to determine roles of structure toxin via bioinformatics experimental validation. Methods Chromosome conformation capture (Hi-C) analysis was used examine interactions among chromosomes identify different...
2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside (THSG), a polyphenol stilbene compound, is the main active constituent in Polygonum multiflorum. In this study, comprehensive analytical strategy was developed for characterization of THSG metabolites vivo (rat plasma, bile, urine, heart, liver, spleen, lung, kidney, and stomach) utilizing ultrahigh performance liquid chromatography coupled with Q Exactive hybrid quadrupole-Orbitrap mass spectrometry (UHPLC-Q Exactive-Orbitrap MS) based on...