A5025900751- Angiogenesis and VEGF in Cancer
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- Acute Ischemic Stroke Management
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Cardiac and Coronary Surgery Techniques
- IL-33, ST2, and ILC Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer, Lipids, and Metabolism
- RNA and protein synthesis mechanisms
- interferon and immune responses
- Periodontal Regeneration and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Tumors and Oncological Cases
- Tissue Engineering and Regenerative Medicine
- Immune cells in cancer
- Wound Healing and Treatments
- NF-κB Signaling Pathways
- Coronary Interventions and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Histone Deacetylase Inhibitors Research
- Acute Myeloid Leukemia Research
- Blood disorders and treatments
Cedars-Sinai Medical Center
2021-2023
The Ohio State University
2015-2017
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2017
Case Western Reserve University
2007-2011
Cleveland Cord Blood Center
2010
MetroHealth Medical Center
2009
Glioblastoma (GB) remains the most aggressive primary brain malignancy. Adoptive transfer of chimeric antigen receptor (CAR)-modified immune cells has emerged as a promising anti-cancer approach, yet potential utility CAR-engineered natural killer (NK) to treat GB not been explored. Tumors from approximately 50% patients express wild-type EGFR (wtEGFR) and in fewer cases both wtEGFR mutant form EGFRvIII; however, previously reported CAR T cell studies only focus on targeting EGFRvIII. Here...
Abstract Aims The metabolic failure of macrophages to adequately process lipid is central the aetiology atherosclerosis. Here, we examine role macrophage angiotensin-converting enzyme (ACE) in a mouse model PCSK9-induced Methods and results Atherosclerosis mice was induced with AAV-PCSK9 high-fat diet. Animals increased ACE (ACE 10/10 mice) have marked reduction atherosclerosis vs. WT mice. Macrophages from both aorta peritoneum express PPARα profoundly altered phenotype lipids characterized...
Abstract Group 3 innate lymphoid cells (ILC3s) are important regulators of the immune system, maintaining homeostasis in presence commensal bacteria, but activating defenses response to microbial pathogens. ILC3s a robust source IL-22, cytokine critical for stimulating antimicrobial response. We sought identify cytokines that can promote proliferation and induce or maintain IL-22 production by determine molecular mechanism this process. identified IL-18 as cooperates with an ILC3 survival...
Granulocytes are key players in cancer metastasis. While tumor-induced de novo expansion of immunosuppressive myeloid-derived suppressor cells (MDSCs) is well-described, the fate and contribution terminally differentiated mature neutrophils to metastatic process remain poorly understood. Here, we show that experimental models, CXCR4hiCD62Llo aged accumulate via disruption neutrophil circadian homeostasis direct stimulation aging mediated by angiotensin II. Compared CXCR4loCD62Lhi naive...
The surface receptor FcγRIIIA (CD16a) is encoded by the FCGR3A gene and acquired human NK cells during maturation. bind Fc portion of IgG via CD16a execute Ab-dependent cell-mediated cytotoxicity, which critical for effectiveness several antitumor mAb therapies. role epigenetic regulatory mechanisms controlling transcriptional posttranscriptional CD16 expression in unknown. In this study, we compared specific patterns DNA methylation with FCGR3B, differ cell type-specific despite displaying...
We sought to determine if the ABCD2 score, typically used for risk stratification, could predict having a positive diagnostic test in patients evaluated acutely transient ischemic attack.We performed retrospective cohort study admitted from our emergency department with new diagnosis of attack confirmed by neurologist. scores were calculated and score > or = 4 placed high-risk cohort. Tests included electrocardiogram, CT, MRI, MR angiography, carotid ultrasonography, echocardiography....
As first responder cells in host defense, neutrophils must be carefully regulated to prevent collateral tissue injury. However, the intracellular events that titrate neutrophil’s response inflammatory stimuli remain poorly understood. a molecular switch, Ras activity is tightly by GTPase activating proteins (RasGAP) maintain cellular active-inactive states. Here, we show RASAL3, RasGAP, highly expressed and its expression upregulated exogenous neutrophils. RASAL3 deficiency triggers...
Lymphoid cell rich fine-needle aspirations (FNAs) of the salivary glands pose a diagnostic dilemma, with wide range differential diagnoses that include several benign and malignant entities. There is limited literature regarding entities are commonly encountered in this situation. Our goal was to characterize surgical outcome these cases evaluate risk malignancy.This retrospective study at tertiary care institution. database queried over 10-year period. FNAs yielding prominent population...
Abstract Here we report that the murine Tox gene encodes two proteins from a single mRNA, and investigate mechanism of production function these proteoforms. The annotated thymocyte selection–associated HMG-box protein (TOX) coding sequence is predicted to produce 526-aa (TOXFL). However, Western blots reveal bands. We found lower band consists an N-terminally truncated variant TOX (TOXΔN), whereas slower-migrating TOXFL. TOXΔN proteoform alternatively translated via leaky ribosomal scanning...
Einleitung: die Apoptose spielt eine wichtige Rolle bei der Wirkung verschiedener Zytostatika. In vorliegenden Arbeit wurde in einem Kollektiv von 51 primären Mammakarzinomen prädiktive Bedeutung apoptoseassoziierter Proteine BCL-2 Familie (BCL-2, Bax und Bad) für ex vivo Chemosensitivität Paclitaxel untersucht.