A5050003364- RNA Interference and Gene Delivery
- vaccines and immunoinformatics approaches
- Nanoparticle-Based Drug Delivery
- Curcumin's Biomedical Applications
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- Bacteriophages and microbial interactions
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Clinical Research Studies
- Chemical Synthesis and Analysis
- Drug Transport and Resistance Mechanisms
- Asthma and respiratory diseases
- Evolution and Genetic Dynamics
- Supramolecular Self-Assembly in Materials
- Protein purification and stability
- Hepatitis B Virus Studies
- Long-Term Effects of COVID-19
- Influenza Virus Research Studies
- Advanced Breast Cancer Therapies
- Mast cells and histamine
- HER2/EGFR in Cancer Research
- Food Allergy and Anaphylaxis Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Iran University of Medical Sciences
2019-2025
Kurdistan University of Medical Sciences
2022
University of Arizona
2022
Kerman University of Medical Sciences
2022
Motamed Cancer Institute
2022
Academic Center for Education, Culture and Research
2022
Arak University
2022
Tehran University of Medical Sciences
2019-2020
University of Tehran
2019
An effective treatment for hormone-dependent breast cancer is chemotherapy using cytotoxic agents such as letrozole (LTZ). However, most anticancer drugs, including LTZ, are classified class IV biopharmaceuticals, which associated with low water solubility, poor bioavailability, and significant toxicity. As a result, developing targeted delivery system LTZ critical overcoming these challenges limitations. Here, biodegradable LTZ-loaded nanocarriers were synthesized by solvent emulsification...
Curcumin (CUR) has potent anticancer activities, and its bioformulations, including biodegradable polymers, are increasingly able to improve CUR’s solubility, stability, delivery cancer cells. In this study, copolymers comprising poly (L-lactide)-poly (ethylene glycol)-poly (L-lactide) (PLA-PEG-PLA) glycol) (PEG-PLA-PEG) were designed synthesized assess compare their CUR-delivery capacity inhibitory potency on MCF-7 breast Molecular dynamics simulations free energy analysis indicated that...
The genetic material within cells plays a pivotal role in shaping the structure and function of living organisms. Manipulating an organism's genome to correct inherited abnormalities or introduce new traits holds great promise. Genetic engineering techniques offers promising pathways for precisely altering cellular genetics. Among these methodologies, clustered regularly interspaced short palindromic repeat (CRISPR), honored with 2020 Nobel Prize Chemistry, has garnered significant attention...
Infectious diseases have caused historical pandemics in the world. Three strategies, including sanitation programs, antimicrobial drugs, and vaccines are considered for prevention treatment of infectious diseases. Today, some cause millions mortalities universally. Due to emergence antibiotic-resistant pathogens, as well limitations traditional vaccines, focusing on novel strategies is essential. Multi-Epitope Vaccines (MEVs), a strategy, been designed based immunoinformatics methods;...
Undoubtedly, the SARS-CoV-2 has become a major concern for all societies due to its catastrophic effects on public health. In addition, mutations and changes in structure of virus make it difficult design effective treatment. Moreover, amino acid sequence protein is factor formation second tertiary protein. Amino replacement can have noticeable folding protein, especially if an asymmetric change (substitution polar residue with non-polar, charged uncharged, positive charge negative charge,...
Abstract The attachment of SARA‐CoV‐2 happens between ACE2 and the receptor binding domain (RBD) on spike protein. Mutations in this can affect affinity protein for ACE2. S477N, one most common mutations reported recent variants, is located RBD. Today's computational approaches biology, especially during SARS‐CoV‐2 pandemic, assist researchers predicting a protein's behavior contact with other proteins more detail. In study, we investigated interactions S477N‐hACE2 silico to find impact...
Infertility is a reproductive system disorder, defined as the failure to become pregnant after 12 months of regular, unprotected intercourse, or produce viable infant [1,2]. Female infertility...
Abstract Background Type A influenza viruses are contagious and even life-threatening if left untreated. So far, no broadly protective vaccine is available due to rapid antigenic changes emergence of new subtypes virus. In this study, we exploited bioinformatics tools in order design a subunit chimeric from the highly conserved regions HA M2 proteins H7N9 subtype We used mucosal adjuvant candidates, including CTxB, STxB, ASP-1, LTB stimulate immunity analyzed combination HA2, M2e, adjuvant....
Abstract Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a large number mutations in its genome have been reported. Some occur noncoding regions without affecting pathobiology virus, while coding are significant. One where mutation can occur, function virus is at receptor‐binding domain (RBD) spike protein. RBD interacts with angiotensin‐converting enzyme (ACE2) and facilitates entry into host cells. There lot focus on mutations, especially displacement...
Chronic hepatitis B (CHB) is the most common cause of hepatocellular carcinoma (HCC) and liver cirrhosis worldwide. In spite numerous advances in treatment CHB, drugs vaccines have failed because many factors like complexity, resistance, toxicity, heavy cost. New RNA interference (RNAi)-based technologies developed innovative strategies to target Achilles' heel several hazardous diseases involving cancer, some genetic disease, autoimmune illnesses, viral disorders particularly virus (HBV)...
Abstract Cell invasion is an important process in cancer progression and recurrence. Invasion implantation of cells from their original place to other tissues, by disabling vital organs, challenges the treatment patients. Given importance matter, many molecular treatments have been developed inhibit cell invasion. Because low production cost ease production, peptides are valuable therapeutic molecules for inhibiting In recent years, advances field computational biology facilitated design...
Abstract The binding of therapeutics to human serum albumin (HSA), which is an abundant protein in plasma poses a major challenge drug discovery. Although HSA has several pockets, the site I on D2 and II D3 are main pockets HSA. To date, few experiments have been conducted examine effects potential hydrogen (pH) changes attributes. In present investigation, effect acidic (pH 7.1) basic states 7.7) structure its potency were examined comparison with physiological state 7.4). For this purpose,...
Curcumin (CUR) is a phytochemical with potent anticancer activities as demonstrated by both preclinical and clinical studies. CUR bioformulations, including loading in biodegradable polymers, have been explored to increase CUR’s solubility chemical stability, control its release, improve delivery cancer cells. In this study, copolymers comprising poly (L-lactide)-poly (ethylene glycol)-poly (L-lactide) (PLA-PEG-PLA) glycol) (PEG-PLA-PEG) were designed synthesized assess compare their...
Polymeric nanoparticles (NPs) have garnered significant interest due to their potential in drug delivery. Specifically, nanopolymers functionalized with molecules such as proteins or peptides serve versatile vehicles for this purpose. Curcumin (Cur) is a widely studied anticancer compound known its positive effects on human health. Nevertheless, insolubility and low bio-distribution hinder the exploitation of beneficial traits. In study, our team developed nanodelivery system using...