A5102822989- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Metastasis and carcinoma case studies
- Photodynamic Therapy Research Studies
- Hydrogen's biological and therapeutic effects
- Cell Adhesion Molecules Research
- Nanoplatforms for cancer theranostics
- Platelet Disorders and Treatments
- Angiogenesis and VEGF in Cancer
- Blood properties and coagulation
- Traditional Chinese Medicine Analysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Biochemical effects in animals
- Protease and Inhibitor Mechanisms
- Anesthesia and Neurotoxicity Research
- Cancer-related molecular mechanisms research
- Periodontal Regeneration and Treatments
- Traditional Chinese Medicine Studies
- RNA Interference and Gene Delivery
- Lung Cancer Research Studies
- Facial Trauma and Fracture Management
- Industrial Technology and Control Systems
West China Hospital of Sichuan University
2020-2025
Sichuan University
2020-2025
State Key Laboratory of Biotherapy
2020
Liaocheng People's Hospital
2011-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
China Academy of Chinese Medical Sciences
2020
Shandong First Medical University
2019
Liaocheng University
2016-2018
University Medical Center Utrecht
2000-2016
Taishan Medical University
2011-2015
Abstract Background Lung cancer has the highest fatality rate of all types. To improve patients’ survival and life quality, it is therefore very important to screen for detect at an early stage. Methods A negative enrichment–fluorescence in situ hybridization (NE‐FISH) approach was used circulating tumor cells (CTCs) lung patients, levels cancer‐associated serum markers were also measured peripheral blood these same patients. The correlation between CTCs, (carcinoembryonic antigen [CEA], CA...
Abstract Osteoarthritis (OA) is a chronic joint disease that causes gradual deterioration of articular cartilage. A major challenge in OA treatment the limited penetration and delivery efficiency drugs to cartilage chondrocytes due rapid clearance through synovial fluid joints osmotic barrier extracellular matrix (ECM). To address this issue, novel tetrahedral framework nucleic acid (tFNA)‐based nanomedicine system (tFNA‐2WL) first synthesized with excellent permeability perfect chondrocyte...
Abstract —We studied the role of von Willebrand Factor (vWF) in platelet thrombus formation flowing blood by using a perfusion system and mutant forms vWF lacking either interaction with glycoprotein Ib (GpIb) or IIb/IIIa (αIIb-β3). These mutants were added to patients severe Willebrand’s disease (vWD) normal reconstituted human albumin solution instead plasma. This was then perfused over collagen type III spray-coated on glass surface preincubated for 2 hours 20 μg/mL plasma vWF. In this...
Endostatin is a fragment of collagen XVIII that acts as an endogenous inhibitor tumor angiogenesis and growth. Anti‐tumor effects have been described using both soluble insoluble recombinant endostatin. However, differences in endostatin structure are likely to cause bioactivity. In the present study we investigated cellular We found shows all hallmarks amyloid aggregates. Firstly, it binds Congo red characteristic apple‐green birefringe when examined under polarized light. Secondly,...
Hydrogen-rich saline has been reported to have antioxidant and anti-inflammatory effects effectively protect against organ damage. Oxidative stress inflammation contribute the pathogenesis and/or development of pulmonary hypertension. In this study, we investigated hydrogen-rich on prevention hypertension induced by monocrotaline in a rat model.In male Sprague-Dawley rats, was subcutaneous administration at concentration 6 mg/100 g body weight. (5 ml/kg) or administered intraperitoneally...
Abstract Background Lung cancer (LC) remains the deadliest form of globally. While surgery optimal treatment strategy for individuals with early-stage LC, what metabolic consequences are such surgical intervention uncertain. Methods Negative enrichment-fluorescence in situ hybridization (NE-FISH) was used an effort to detect circulating tumor cells (CTCs) pre- and post-surgery peripheral blood samples from 51 LC patients. In addition, targeted metabolomics analyses, multivariate statistical...
Shenfu decoction (SFD) can be used to treat patients with sign of Yangqi decline or Yang exhaustion related chronic heart failure (CHF). We conducted a gas chromatography time-of-flight mass spectrometer (GC/TOF–MS)-based metabolomic study increase the understanding CHF and assess efficacies mechanisms SFD in treating induced by coronary artery ligation rats. Based on unsupervised principal component analysis, there was clear separation between sham surgery group, which revealed that...
The novel synthetic peptide P17-BMP-2 could promote cell attachment and enhance osteogenic capability. A composite, comprising nano-hydroxyapatite, collagen poly(L-lactide) (nHAC/PLLA), was an efficient scaffold for carrier of P17-BMP-2. Our aim to investigate whether nHAC/PLLA/P17-BMP-2 ac celerates the osteogenesis as a reliable method mandibular defect healing in this study. repair capability assessed by gross observation, X-ray test histological observation four animal experiment groups...
Photodynamic therapy (PDT) produces reactive species that alter vascular wall biology and vessel proteins. In this study, we examined platelet adhesion to PDT-treated (photosensitizer = Photofrin; fluence 100 J/cm2; λ 630 nm) extracellular matrix (ECM), fibrinogen, von Willebrand factor (vWF) collagen Types I III, under flow conditions in a recirculating perfusion chamber. Platelet was quantified by image analysis. The effect of PDT on vWF assessed measuring the binding domain-specific...
G protein-coupled receptors (GPR) are involved in a wide range of physiological processes, some which, however, can be hijacked by tumor cells. Over-expression 137 (GPR137) associated with the growth cells, but under-expression GPR137 has shown to inhibit cell proliferation several different types cancers. Currently, role leukemia is still unclear. In this study, effect on inhibiting cells explored, identify novel target for treatment. lentivirus-mediated RNA interference (RNAi) was employed...
Abstract Background: Lung cancer (LC) remains the deadliest form of globally. While surgery optimal treatment strategy for individuals with early-stage LC, what metabolic consequences are such surgical intervention uncertain. Methods: Negative enrichment-fluorescence in situ hybridization (NE-FISH) was used an effort to detect circulating tumor cells (CTCs) pre- and post-surgery peripheral blood samples from 51 LC patients. In addition, targeted metabolomics analyses, multivariate...
Abstract Background Lung cancer (LC) remains the deadliest form of globally. While surgery optimal treatment strategy for individuals with early-stage LC, what metabolic consequences are such surgical intervention uncertain. Methods Negative enrichment-fluorescence in situ hybridization (NE-FISH) was used an effort to detect circulating tumor cells (CTCs) pre- and post-surgery peripheral blood samples from 51 LC patients. In addition, targeted metabolomics analyses, multivariate statistical...
Material corrosion is a serious threat to power apparatus, equipments, buildings and personal safety, brings huge economic losses large amount of resources energy consumption all countries in the world. Corrosion data difficult be effectively treated by traditional analysis methods due its quantity, structural differences uneven quality. The emergence mining technology plays crucial role analyzing material data, building models, studying laws predicting long-term development trends...