A5003033212- Opioid Use Disorder Treatment
- Substance Abuse Treatment and Outcomes
- Neurotransmitter Receptor Influence on Behavior
- HIV, Drug Use, Sexual Risk
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Pain Management and Opioid Use
- Mental Health Treatment and Access
- Treatment of Major Depression
- Digital Mental Health Interventions
- Pain Management and Placebo Effect
- Neural and Behavioral Psychology Studies
- Mental Health and Patient Involvement
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Neuroethics, Human Enhancement, Biomedical Innovations
- Face Recognition and Perception
- Mental Health Research Topics
- Suicide and Self-Harm Studies
- Health Policy Implementation Science
- Forensic Toxicology and Drug Analysis
- Pharmaceutical Practices and Patient Outcomes
- Attention Deficit Hyperactivity Disorder
- Early Childhood Education and Development
University of Maryland, Baltimore
2016-2025
Charleston Area Medical Center
2025
University of Maryland, College Park
2022
University of California, San Francisco
2022
Johns Hopkins University
2022
National Institutes of Health
2005-2016
National Institute on Drug Abuse
2009-2016
University of California, Irvine
2004-2009
Resting-state functional MRI is a powerful tool that increasingly used as noninvasive method for investigating whole-brain circuitry and holds great potential possible diagnostic disease. Despite this potential, few resting-state studies have animal models (of which nonhuman primates represent our best opportunity of understanding complex human neuropsychiatric disease), no work has characterized networks in awake, truly resting animals. Here we present results from small New World monkey...
Identifying nonaddictive opioid medications is a high priority in medical science, but μ-opioid receptors (MORs) mediate both the analgesic and addictive effects of opioids. We found significant pharmacodynamic difference between morphine methadone that determined entirely by heteromerization MORs with galanin Gal1 (Gal1Rs), rendering profound decrease potency methadone. This finding was explained weaker proficiency activating dopaminergic system as compared predicted dissociation...
<h3>Importance</h3> The demand for medications opioid use disorder (MOUD) in rural US counties far outweighs their availability. Novel approaches to extend treatment capacity include telemedicine (TM) and mobile on demand; however, combined has not been reported or evaluated. <h3>Objective</h3> To evaluate the of a TM unit (TM-MTU) improve access MOUD individuals living an underserved area. <h3>Design, Setting, Participants</h3> This quality improvement study evaluated data collected from...
Neurocognitive and emotional regulatory deficits in substance users are often attributed to misuse; however most studies do not include a substance-naïve baseline justify that conclusion. The etiological literature suggests pre-existing may contribute the onset escalation of use then exacerbated by subsequent use. To address this, there is burgeoning interest conducting prospective, longitudinal neuroimaging isolate neurodevelopmental precursors consequences adolescent misuse, as reflected...
In combination with advances in analytical methods, resting-state fMRI is allowing unprecedented access to a better understanding of the network organization brain. Increasing evidence suggests that this architecture may incorporate highly functionally connected nodes, or "hubs", and we have recently proposed local functional connectivity density (lFCD) mapping identify highly-connected nodes human Here, imaged awake nonhuman primates test whether, like brain, marmoset brain contains FC...
Despite the widespread availability of naloxone, US opioid overdose rates continue to rise. The "Cascade Care" (CoC) is a public health approach that identifies steps in achieving specific outcomes and has been used identify gaps naloxone carriage among individuals with use disorder (OUD). We sought apply this framework treatment-seeking population OUD may be more inclined engage harm reduction behaviors.Patients were recruited from an urban methadone program complete survey. assessed...
Methadone treatment is the most effective evidence-based for opioid use disorder (OUD), but challenges related to dosing and premature dropout argue adjunct interventions improve outcomes. One potential behavioral intervention with low risk involves harnessing placebo effects.
Abstract Background Despite efficacy of medication for opioid use disorder, low-income, ethno-racial minoritized populations often experience poor disorder treatment outcomes. Peer recovery specialists, individuals with lived substance and recovery, are well-positioned to engage hard-to-reach patients in disorder. Traditionally, peer specialists have focused on bridging care rather than delivering interventions. This study builds research other low-resource contexts that has explored...