A5039690924- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Occupational exposure and asthma
- Pediatric health and respiratory diseases
- Renal function and acid-base balance
- Radiation Dose and Imaging
- Atomic and Subatomic Physics Research
- Lung Cancer Diagnosis and Treatment
Central Finland Health Care District
2019-2023
Seinäjoki University of Applied Sciences
2016-2021
The aim of this study was to evaluate the effect smoking on lung function decline in adult-onset asthma a clinical, 12-year follow-up study.In Seinäjoki Adult Asthma Study, 203 patients were followed for 12 years (1999-2013) after diagnosis new-onset adult asthma. Patients divided into two groups based history: <10 or ≥10 pack-years. Spirometry evaluation points were: 1) baseline, 2) maximum during first 2.5 (Max0-2.5) and 3) follow-up.Between Max0-2.5 follow-up, median annual absolute...
Previous cluster analyses on asthma are based cross-sectional data.To identify phenotypes of adult-onset by using data from baseline (diagnostic) and 12-year follow-up visits.The Seinäjoki Adult Asthma Study is a study patients with new-onset adult asthma. K-means analysis was performed variables visits 171 to phenotypes.Five clusters were identified. Patients in 1 (n = 38) predominantly nonatopic males moderate smoking history at baseline. At follow-up, 40% these had developed persistent...
Differences between asthma–COPD overlap syndrome (ACOS) and adult-onset asthma are poorly understood. This study aimed to evaluate these differences in a clinical cohort of patients with asthma, as part the Seinäjoki Adult Asthma Study (SAAS). 188 were diagnosed re-evaluated 12 years after diagnosis. They divided into three groups based on smoking history post bronchodilator spirometry values: 1) never- ex-smokers <10 smoked pack-years; 2) non-obstructive (forced expiratory volume 1 s...
Background: There is a lack of knowledge on the association between daily physical activity and lung function in patients with asthma. Objective: This study aims to examine asthma control, function, decline adult-onset Design: part Seinäjoki Adult Asthma Study (SAAS), where 201 were followed for 12 years after diagnosis. Daily was assessed at follow-up by structured questionnaire used classify population into subgroups low (≤240 min) or high (>240 activity. Three spirometry evaluation points...
Adherence to inhaled corticosteroids (ICS) has been suggested be poor but long-term follow-ups are lacking. The objective of the present study was assess adherence ICS treatment in patients with adult-onset asthma during 12-year follow-up. A total 181 clinically confirmed, new-onset adult were followed for 12 years as part Seinäjoki Adult Asthma Study. assessed individually percentage true dispensed micrograms per prescribed daily over years. Mean 69% (mean± sd 2.5±1.8 g and 3.6±1.5...
<b>Occupational exposure to vapours, gases, dusts or fumes (VGDF) increases the prevalence of asthma–COPD overlap (ACO) in adult-onset asthma. VGDF is independently associated with ACO and an additive effect smoking proposed.</b>http://bit.ly/2LiMiXW
Spirometry and testing for bronchodilator response have been recommended to detect asthma, a (BDR) of ≥12% ≥200 mL has suggested confirm asthma. However, the clinical value bronchodilation tests in newly diagnosed steroid-naïve adult patients with asthma remains unknown. We evaluated sensitivity BDR forced expiratory volume 1 s (FEV ) as diagnostic test real-life cohort participants Seinäjoki Adult Asthma Study. In phase, 369 spirometry were performed 219 patients. The fulfilment each...
<b>Background:</b> Adherence to inhaled corticosteroids (ICS) has been suggested be poor but long-term follow-ups are lacking. <b>Aims and Objectives:</b> To address adherence ICS treatment in patients with adult-onset asthma during 12 year follow-up. <b>Methods:</b> A total of 181 clinically confirmed new-onset adult were followed for years as part Seinäjoki Adult Asthma Study (SAAS). was assessed individually the percentage true dispensed µg per prescribed daily whole years. not a stable...
Possible variation in bronchodilator response (BDR) according to age at the diagnosis of adult-onset asthma is unknown. Our aim was assess if BDR FEV1 related and how many subjects fulfill 400 mL criterion BDR, suggested cut-off for asthma-like reversibility asthma-COPD overlap (ACO). A total 1030 patients with were included; 245 from SAAS (Seinäjoki Adult Asthma Study, Finland) 785 COREA (Cohort Reality Evolution Korea) cohorts. assessed. Patients divided into groups based on diagnosis: <...
<b>Background:</b> Predictors of long-term lung function decline in adult-onset asthma are not known. <b>Aims:</b> To evaluate the determinants for accelerated loss a 12-year follow-up as part Seinäjoki Adult-onset Asthma Study (SAAS). <b>Methods:</b> 257 adults were diagnosed with new-onset during 1999-2002. After 12 years patients (n=203) re-evaluated. Spirometry measurement points were:1.) baseline (i.e. time diagnosis), 2.) maximum (Max<sub>0-2.5</sub>) first 2.5 after diagnosis start...
<b>Background:</b> The effect of smoking on the long-term decline in lung function adult-onset asthma is not known. <b>Aims and Objectives:</b> To evaluate smoked pack-years a 12-year follow-up as part Seinäjoki Adult-onset Asthma Study (SAAS). <b>Methods:</b> Patients (n=257) were diagnosed to have new-onset adult during 2000-2002. At time diagnosis history was assessed. After 12 years (2012-2013) patients (n=203) evaluated for status. divided into two groups based pack-years: ≤ 10 >10....
<b>Background</b> Previous cluster analyses on asthma are based cross-sectional data. <b>Aims and objectives</b> To identify phenotypes of adult-onset by using data from baseline (diagnostic) 12 year follow-up visits. <b>Methods</b> Seinäjoki Adult Asthma Study (SAAS) is a 12-year study patients with new-onset adult asthma. K-means analysis was performed variables visits 171 to phenotypes. <b>Results</b> Five clusters were identified. Patients in 1 (n=38) predominantly non-atopic males...
<b>Background</b>: Differences between ACOS and adult-onset asthma (AOA) are poorly known. <b>Aims</b>: To evaluate these differences as a part of Seinäjoki Adult-onset Asthma Study (SAAS). <b>Methods</b>: 257 adults were diagnosed with new-onset during 1999-2002. After 12 years (2012-2013) patients (n=203) re-evaluated, divided into 4 groups based on smoking history post bronchodilator spirometry values: 1.)<10 pack-years smoking, no obstruction (FEV1/FVC≥0.7), 2.)<10 pack-years,...
Plasma nitrite
<b>Background:</b> Asthma is characterized by variable and reversible expiratory airflow limitation. Thus, it logical to use the change in FEV<sub>1</sub> response a bronchodilating drug (∆FEV<sub>1</sub>BDR) as diagnostic tool. An increase of ≥12% ≥200mL from baseline has often been considered diagnostic. <b>Aim:</b> To evaluate historical development cut-off-levels ∆FEV<sub>1</sub>BDR for adults well evidence behind these recommendations. <b>Methods:</b> find out how tool adult asthma...
<b>Introduction</b> Tobacco smoking has been associated with reduced response to inhaled corticosteroids (ICS) in asthma treatment. However, little is known about how affects lung function after initiation of ICS treatment new-onset asthma. <b>Aims and objectives</b> To evaluate the sub-acute on new adult-onset steroid-naïve patients. <b>Methods</b> In Seinäjoki Adult Asthma Study, 203 patients were followed for 12 years. Patients who dispensed during first two years follow-up included...
<b>Background:</b> Differences between obstructive asthma and asthma-COPD overlap syndrome (ACOS) are poorly known. <b>Aims:</b> To evaluate these differences in Seinäjoki Adult-onset Asthma Study (SAAS) cohort. <b>Methods:</b> 257 patients were diagnosed with new-onset adult during 1999-2002. After 12 years (2012-2013) (n=203) re-evaluated, 2 groups of chosen for analysis: 1) non-smoking asthmatic fixed obstruction (<10 pack-years smoking post bronchodilator [BD]...
<b>Background:</b> Diagnostic criteria of asthma-COPD overlap (ACOS) are under discussion. Recently, it has been suggested that as a for ACOS, asthma should be diagnosed before age 40 years<sup>1</sup>. However, increasing evidence shows persistent is often at older age<sup>2</sup>. <b>Aims:</b> Our aim was to assess the proportion patients who with years in Finland, and evaluate validity consequences limit. <b>Methods:</b> In Finland every patient novel entitled medication reimbursement by...
<b>Background:</b> There is a lack of knowledge on the association between physical activity and lung function in patients with asthma. The objective this study was to investigate significance daily adult-onset asthma, including all intensities movement from incidental vigorous exercise. <b>Methods:</b> This part Seinäjoki Adult Asthma Study (SAAS), where 203 were followed for 12 years after asthma diagnosis. Daily at follow-up assessed by structured questionnaire used classify population...
<b>Background:</b> The effect of cumulative smoking history on the disease burden asthma is poorly known. <b>Aim:</b> To assess impact smoked pack-years hospitalizations, comorbidities and symptoms in adult-onset asthma. <b>Methods:</b> In Seinäjoki Adult Asthma Study (SAAS) 257 patients were diagnosed with (years 1999-2002), 12 years later 193 known detailed re-evaluated. Current ex-smokers (n=97) analyzed 3 groups based as follows: 1) 0.1-9.9, 2) 10-19.9, 3) ≥20 pack-years. <b>Results:</b>...
<b>Background:</b> To avoid over-diagnosing of asthma-COPD overlap (ACO), a higher cut-off 400mL for bronchodilator response (BDR) in FEV<sub>1</sub> has been proposed patients with asthma diagnosed at age ≥40 years. However, it is not known how many asthmatics fulfill this criterion and whether BDR related to diagnosis adult-onset asthma. <b>Aim:</b> assess if subjects the 400 mL BDR. <b>Methods:</b> 1030 (age onset ≥15 years) were included; 245 from SAAS (Seinäjoki Adult Asthma Study) 785...
<b>Background:</b> The role of occupational exposures (OE) in the development Asthma-COPD overlap (ACO) is not known. <b>Aim:</b> To study if ACO among subjects with adult-onset asthma associated OE to vapors, gases, dusts and fumes (VGDF). <b>Methods:</b> 194 patients known pack-year history (≥0 pack-years) were included from cohort Seinäjoki Adult Asthma Study (SAAS). Spirometry was measured, data collected by a structured questionnaire. Patients ≥10 pack-years post bronchodilation...