A5058974299- Plant Stress Responses and Tolerance
- Organometallic Compounds Synthesis and Characterization
- Synthesis and biological activity
- RNA Research and Splicing
- Photosynthetic Processes and Mechanisms
- Natural product bioactivities and synthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Bioactive Compounds and Antitumor Agents
- Multiple Sclerosis Research Studies
- Antimicrobial Peptides and Activities
- Chemical Synthesis and Analysis
- Bacillus and Francisella bacterial research
- Ginseng Biological Effects and Applications
- Essential Oils and Antimicrobial Activity
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Lipid metabolism and biosynthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Edible Oils Quality and Analysis
- Cancer Mechanisms and Therapy
- Computational Drug Discovery Methods
- Hippo pathway signaling and YAP/TAZ
- Plant-Microbe Interactions and Immunity
- Cancer-related molecular mechanisms research
- Plant Gene Expression Analysis
Yarmouk University
2022-2025
Martin Luther University Halle-Wittenberg
2021-2025
Institute of Molecular Medicine
2025
Leibniz Institute of Plant Biochemistry
2017-2024
Background: Thieno[2,3-c]pyridines and their analogs are not well explored for anticancer properties. Hence, our research aimed to establish the potential of thieno[2,3-c]pyridines through cell-based assays in silico evaluations. Methods: Thieno[2,3-c]pyridine derivatives 6(a–k) were synthesized characterized using FT-IR, 1H-NMR, 13C-NMR, HRMS. All compounds screened initially activity against MCF7 T47D (breast cancer), HSC3 (head neck RKO (colorectal cancer) cell lines MTT assay. Apoptosis...
Objective: In this study, 25 synthetic cyclic lipopeptides (CLPs) were investigated for their anticancer potential against mouse melanoma (B16F10) cells, human prostate cancer (PC-3), colorectal adenocarcinoma (HT-29) and embryonic fibroblast (NIH3T3) cells. Methods: The cytotoxic activity of compounds was evaluated using MTT CV assays. order to examine the mechanism action most potent compound cell cycle analysis, apoptosis assay, caspase activity, CFSE DHR staining, DAF-FM, autophagy...
Abstract The Hippo/YAP1 signaling pathway regulates normal development by controlling contact inhibition of growth. In cancer, YAP1 activation is often dysregulated, leading to excessive tumor growth and metastasis. SRC kinase can cross talk Hippo disrupting adherens junctions, repressing the cascade, or activating promote proliferation. Here, we demonstrate that IGF2 messenger RNA-binding protein 1 (IGF2BP1) impedes repression in carcinomas. IGF2BP1 stabilizes RNA (mRNA) enhances synthesis...
Proteome remodeling is a fundamental adaptive response, and proteins in complexes functionally related are often co-expressed. Using deep sampling strategy we define core proteomes of Arabidopsis thaliana tissues with around 10 000 per tissue, absolutely quantify (copy numbers cell) nearly 16 throughout the plant lifecycle. A proteome-wide survey global post-translational modification revealed amino acid exchanges pointing to potential conservation translational infidelity eukaryotes....
Two birds in one shot: oligopeptides can be cyclized and lipidated step with multicomponent reactions.
Various cyclic lipopeptides (CLPs, 23 compounds) were tested for their antitumor potential against human cervix adenocarcinoma HeLa cells. From the fast screening (tested concentrations: 0.01 and 10 ?M) compound ((12S,6S,10S,13S)-6-((R)-sec-butyl)-7-(2-(dodecylamino)-2-oxoethyl)-13-isopropyl- 82-nitro-2,5,12,15-tetraoxo-4,7,11,14-tetraaza-1(1,2)-pyrrolidina-8(1,4)-benzenacyclopentadecaphane- 10-carboxamide) was identified as active cell line. The MTT...
Olive mill wastewater (OMW) poses a significant environmental challenge and health concern in olive-producing countries, including Jordan. Surfactant micelles are frequently employed as solubilizing agents to enhance the water solubility of chemical compounds. This study aims leverage sodium dodecyl sulfate (SDS) multi-step process detoxify OMW for agricultural industrial uses reduce its impact. The was treated multiple steps: screening, coagulation with different chemicals, distillation...
Abstract Background Tongue squamous cell carcinoma (TSCC) is an aggressive cancer associated with a poor prognosis and limited treatment options, necessitating new drug targets to improve therapeutic outcomes. Our current work focuses on protein tyrosine kinases as well-known for successful therapies. Methods Western blot analysis of phosphorylation patterns in 34 TSCC lines identified Src family (SFKs) the main contributors. Inhibition SFKs PP2 Dasatinib led profound biological effects. A...
Abstract Proteome remodeling is a fundamental adaptive response and proteins in complex functionally related are often co-expressed. Using deep sampling strategy we define Arabidopsis thaliana tissue core proteomes at around 10,000 per absolutely quantify (copy numbers cell) nearly 16,000 throughout the plant lifecycle. A proteome wide survey of global post translational modification revealed amino acid exchanges pointing to potential conservation infidelity eukaryotes. Correlation analysis...