A5101860282- Advanced NMR Techniques and Applications
- Solid-state spectroscopy and crystallography
- NMR spectroscopy and applications
- Organic Light-Emitting Diodes Research
- Organic Electronics and Photovoltaics
- Luminescence and Fluorescent Materials
- Cancer-related molecular mechanisms research
- Muon and positron interactions and applications
- Extraction and Separation Processes
- Metal Extraction and Bioleaching
- Advanced MRI Techniques and Applications
- Perovskite Materials and Applications
- Protein Structure and Dynamics
- Genetic and phenotypic traits in livestock
- Conducting polymers and applications
- Bauxite Residue and Utilization
- Alzheimer's disease research and treatments
- Catalysis and Oxidation Reactions
- Catalytic Cross-Coupling Reactions
- Genetic Mapping and Diversity in Plants and Animals
- Plant biochemistry and biosynthesis
- Molecular spectroscopy and chirality
- Mesoporous Materials and Catalysis
- Supramolecular Self-Assembly in Materials
- Advancements in Battery Materials
Fuzhou University
2025
Jiangnan University
2019-2024
Nanyang Technological University
2024
Southwest University of Science and Technology
2023
Max Planck Institute for Biophysical Chemistry
2020-2022
Jiangsu University of Science and Technology
2022
Center for Life Sciences
2021
Central South University
2017-2021
Beijing National Laboratory for Molecular Sciences
2021
Peking University
2021
The available magnetic field strength for high resolution NMR in persistent superconducting magnets has recently improved from 23.5 to 28 Tesla, increasing the proton resonance frequency 1 1.2 GHz. For magic-angle spinning (MAS) NMR, this is expected improve resolution, provided sample preparation results homogeneous broadening. We compare two-dimensional (2D) detected MAS spectra of four membrane proteins at 950 and 1200 MHz. find a consistent improvement that scales superlinearly with...
Membrane-assisted amyloid formation is implicated in human diseases, and many of the aggregating species accelerate induce cell death. While structures membrane-associated intermediates would provide tremendous insights into pathology aid design compounds to potentially treat it has not been feasible overcome challenges posed by membrane. Here, we use NMR experimental constraints solve structure a type-2 diabetes related islet polypeptide intermediate stabilized nanodiscs. ROSETTA MD...
Various types of Ti-containing zeolites, i.e., Ti-MWW, TS-1, Ti-MOR, and Ti-BEA, have been evaluated as candidates for the liquid-phase oxidation cyclohexane using t-butyl hydroperoxide (TBHP, 7–8 wt %) model oxidant. Ti-MWW zeolite displayed highest activity cyclohexanol cyclohexanone (KA oil) with an overall selectivity higher than 90% at 80 °C, making this catalyst a candidate choice industrial KA oil production by deperoxidation cyclohexyl hydroperoxide. The effect reaction temperature,...
Abstract Developing novel and efficient cathode interlayers (CILs) for organic solar cells has been a hot topic due to its significance the device performance. In this work, series of asymmetric molecules containing boron‐nitrogen coordination bonds (B←N) with backbone dipoles is disclosed innovatively applied as CILs OSCs. By tailoring substituents on boron, dipole moments, intramolecular charge transfer (ICT) properties, compatibility active layer these B←N embedded can be well...
MAS solid-state NMR is capable of determining structures protonated solid proteins using proton-detected experiments. These experiments are performed at rotation frequency around 110 kHz, employing 0.5 mg material. Here, we compare 1H, 13C correlation spectra obtained from and deuterated microcrystalline 111 show that the spectral quality samples superior to those acquired in terms resolution sensitivity. In comparison samples, yield a gain on order 3 2 proton carbon dimensions,...
In the last decade, proton detection in magic-angle spinning (MAS) solid-state NMR became a popular strategy for biomolecular structure determination. particular, probe technology has experienced tremendous progress with smaller and diameter rotors achieving ever higher MAS frequencies. rotation frequencies beyond 100 kHz allow to observe assign protons fully protonated samples. these experiments, resolution is however compromised as homogeneous proton–proton dipolar coupling interactions...
Homonuclear dipolar recoupling is routinely used for magic-angle spinning NMR-based structure determination. In fully protonated samples, only short proton-proton distances are accessible to broadband approaches because of high proton density. Selective methods allow detection longer by directing polarization a subset spins. Here we introduce the selective pulse sequence MODIST, which recouples spins that have modest chemical shift offset difference, and demonstrate it selectively record...
Abstract Magic‐angle spinning (MAS) is an essential ingredient in a wide variety of solid‐state NMR experiments. The standard procedures to adjust the rotor angle are not highly accurate, resulting slight misadjustment from magic ( ) on order few millidegrees. This small missetting has no significant impact overall spectral resolution, but sufficient reintroduce anisotropic interactions. Shown here that site‐specific 1 H‐ 15 N dipolar couplings can be accurately measured heavily deuterated...
<b><i>Background:</i></b> In this study, we examined whether RORA (retinoic acid receptor-related orphan receptor alpha) was capable of alleviating the progression allergic rhinitis (AR). <b><i>Methods:</i></b> order to elucidate possible effects and regulatory mechanism between Wnt/β-catenin signaling pathway, mouse AR models were established treated with vector, siRNA against RORA, or pathway inhibitor WIF-1. Subsequently, serum levels...
We disclose the unprecedented hybrid-ruthenium catalysis for distal meta-C-H activation. The catalyst was recyclable, as proven by various heterogeneity tests, and fully characterized with microscopic spectroscopic techniques, highlighting physical chemical stability. Thereby, proved broadly applicable alkylations of among others purine-based nucleosides natural product conjugates. Additionally, its versatility further reflected activations through visible-light irradiation, well...
Sensitivity and resolution together determine the quality of NMR spectra in biological solids. Higher magic angle spinning frequencies yield a more efficient suppression coupling network enable atomic-level investigations protonated protein samples. On other hand, truncation effects induced by higher magnetic fields have an impact on achievable sensitivity resolution. In this work, we address question how proton dipolar affects field strength-dependent gains We find that—beyond canonical...
Co-localizing biochemical processes is a great strategy when expressing the heterologous metabolic pathway for product biosynthesis. The RNA scaffold flexible and efficient synthetic compartmentalization method to co-localize enzymes involved in by binding specific RNA, domains fused with engineered enzymes. Herein, we designed two artificial structures─0D scaffolds 2D scaffolds─using reported aptamers PP7 BIV-Tat corresponding RNA-binding (RBDs). We verified interaction of RBD aptamer vitro...
Abstract Two Y chromosome specific microsatellites UMN2404 and UMN0103 were genotyped assessed for polymorphisms in a total of 423 unrelated males from 25 indigenous Chinese cattle breeds. Consistently, both displayed indicine taurine alleles each bull examined. The detected 248 (58.6%), 175 (41.4%), respectively, although these frequencies varied amongst different breeds dominated the southern group (92.4%), while northern (95.5%). Hainan Island was possibly site origin zebu, Tibetan...
Abstract The molecular design of purely organic fluorophores for highly efficient and stable deep‐blue light‐emitting diodes (OLEDs) is still a challenge. Excellent performances in terms Commission Internationale de l'Eclairage (CIE) coordinates, external quantum efficiency (EQE), brightness lifespan, often cannot be achieved simultaneously one OLED. Herein, novel carbazole‐based thermally activated delayed fluorescence emitter DPFCz ‐ TRZ designed synthesized through Friedel‐Crafts...