A5044523133- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- Enzyme function and inhibition
- RNA Interference and Gene Delivery
- Protease and Inhibitor Mechanisms
- Ultrasound and Hyperthermia Applications
- Chemical Synthesis and Analysis
- Photoacoustic and Ultrasonic Imaging
- Histone Deacetylase Inhibitors Research
- Molecular Sensors and Ion Detection
- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Polydiacetylene-based materials and applications
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Connective Tissue Growth Factor Research
- Luminescence and Fluorescent Materials
- Signaling Pathways in Disease
- Cholinesterase and Neurodegenerative Diseases
- Chemical Reactions and Mechanisms
- Lipid Membrane Structure and Behavior
- Analytical Chemistry and Sensors
South Dakota State University
2024-2025
North Dakota State University
2015-2024
Dakota State University
2010-2024
Wells Fargo (United States)
2014-2020
Case Western Reserve University
1991-2016
Cornell University
2016
University of Leeds
2016
PhytoCeutica (United States)
2015
Institute of Life Sciences
2011
University of North Dakota
2005-2009
Three-dimensional (3D) bio-printing is a revolutionary technology to reproduce 3D functional living tissue scaffold in-vitro through controlled layer-by-layer deposition of biomaterials along with high precision positioning cells. Due its bio-compatibility, natural hydrogels are commonly considered as the material. However, mechanical integrity hydrogel material, especially in architecture, an issue. In this research, novel hybrid hydrogel, that is, sodium alginate carboxymethyl cellulose...
Hypoxia in tumors contributes to overall tumor progression by assisting epithelial-to-mesenchymal transition, angiogenesis, and metastasis of cancer. In this study, we have synthesized a hypoxia-responsive, diblock copolymer poly(lactic acid)-azobenzene-poly(ethylene glycol), which self-assembles form polymersomes an aqueous medium. The did not release any encapsulated contents for 50 min under normoxic conditions. However, hypoxia, 90% the dye was released min. combination anticancer drugs...
Significant differences in biochemical parameters between normal and tumor tissues offer an opportunity to chemically design drug carriers which respond these changes deliver the drugs at desired site. For example, overexpression of matrix metalloproteinase-9 (MMP-9) enzyme extracellular can act as a trigger modulate delivery from carriers. In this study, we have synthesized MMP-9-cleavable, collagen mimetic lipopeptide forms nanosized vesicles with POPC, POPE-SS-PEG,...
Biological nanoparticles, such as exosomes, offer an approach to drug delivery because of their innate ability transport biomolecules. Exosomes are derived from cells and integral component cellular communication. However, the cargo human exosomes could negatively impact use a safe carrier. Additionally, have intrinsic yet enigmatic, targeting characteristics complex Hence, harnessing natural abilities for requires predictably these biological nanoparticles. This manuscript describes two...
In pancreatic ductal adenocarcinoma (PDAC), early onset of hypoxia triggers remodeling the extracellular matrix, epithelial-to-mesenchymal transition, increased cell survival, formation cancer stem cells, and drug resistance. Hypoxia in PDAC is also associated with development collagen-rich, fibrous stroma (desmoplasia), resulting severely impaired penetration. To overcome these daunting challenges, we created polymer nanoparticles (polymersomes) that target penetrate tumors, reach hypoxic...
Solid tumors are often poorly irrigated due to structurally compromised microcirculation. Uncontrolled multiplication of cancer cells, insufficient blood flow, and the lack enough oxygen nutrients lead development hypoxic regions in tumor tissues. As partial pressure drops below necessary level (10 psi), cells modulate their genetic makeup survive. Hypoxia triggers progression by enhancing angiogenesis, stem cell production, remodeling extracellular matrix, epigenetic changes cells. However,...
Pancreatic ductal adenocarcinoma (PDAC), a metabolic disorder, remains one of the leading cancer mortality sources worldwide. An initial response to treatments, such as gemcitabine (GEM), is often followed by emergent resistance reflecting an urgent need for alternate therapies. The PDAC GEM could be due ERK1/2 activity. However, successful ERKi therapy hindered low ligand efficiency, poor drug delivery, and toxicity. In this study, overcome these limitations, we have designed pH-responsive...
Matrix metalloproteinases (MMPs) constitute a class of extracellular-matrix-degrading enzymes overexpressed in many cancers and contribute to the metastatic ability cancer cells. We have recently demonstrated that liposomal contents can be released when triggered by enzyme MMP-9. Herein, we report results our mechanistic studies MMP-9-triggered release contents. synthesized peptides containing cleavage site for MMP-9 conjugated them with fatty acids prepare corresponding lipopeptides. By...
Liposomes have been widely used as a drug delivery vehicle, and currently, more than 10 liposomal formulations are approved by the Food Drug Administration for clinical use. However, upon targeting, release of liposome-encapsulated contents is usually slow. We recently demonstrated that from appropriately formulated liposomes can be rapidly released cancer-associated enzyme matrix metalloproteinase-9 (MMP-9). Herein, we report our detailed studies to optimize formulations. By properly...
The effects of NaCl on the H2O2 content and activities catalase (CAT) superoxide dismutase (SOD) were studied in diverse group plants, such as a unicellular alga, Chlorella sp., an aquatic macrophyte, Najas graminea, mangrove plant, Suaeda maritima, all showing high tolerance to NaCl. Significant accumulation was observed tested plants upon their exposure 255 mM activity both CAT SOD increased significantly response treatment. Growing presence also resulted synthesis new isoforms SOD.
Abstract The ability to map multiple biomarkers at the same time has far‐reaching biomedical and diagnostic applications. Here, a series of biocompatible poly( d,l ‐lactic‐ co ‐glycolic acid) polyethylene glycol particles for multicolor multiplexed imaging are reported. More than 30 particle formulations that exhibit distinct emission signatures (ranging from visible NIR wavelength region) designed synthesized. These encapsulated with combinations carbocyanine‐based fluorophores DiO, Dil,...
Gene therapy holds immense potential as a future therapeutic strategy for the treatment of numerous genetic diseases which are incurable to date. Nevertheless, safe and efficient gene delivery remains most challenging aspects therapy. To overcome this difficulty series hexanoic acid (HA) monomethoxy poly(ethylene glycol) (mPEG) double grafted chitosan-based (HPC) nanomicelles were developed nonviral carrier. HPC polymers with various HA mPEG substitution degrees synthesized, their chemical...
Improving the therapeutic index of anticancer agents is an enormous challenge. Targeting decreases side effects by delivering drugs to intended destination. Nanocarriers containing nuclear localizing peptide sequences (NLS) translocate cell nuclei. However, localization peptides are nonselective and cannot distinguish malignant cells from healthy counterparts. In this study, we designed a "masked" NLS which activated only in presence overexpressed matrix metalloproteinase-7 (MMP-7) enzyme...