A5103245704- Circular RNAs in diseases
- Inflammasome and immune disorders
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- Bioactive Natural Diterpenoids Research
- Connexins and lens biology
- Monoclonal and Polyclonal Antibodies Research
- Head and Neck Cancer Studies
- MicroRNA in disease regulation
- GDF15 and Related Biomarkers
- CAR-T cell therapy research
- Autoimmune and Inflammatory Disorders Research
- Cancer Research and Treatments
- Thermoregulation and physiological responses
- Vascular anomalies and interventions
- Atherosclerosis and Cardiovascular Diseases
- Lipid metabolism and disorders
- Connective tissue disorders research
- Genetics, Bioinformatics, and Biomedical Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Systemic Lupus Erythematosus Research
Affiliated Hospital of North Sichuan Medical College
2020-2025
National Medical Products Administration
2024
Peking University Cancer Hospital
2024
Peking University
2024
Beijing Anzhen Hospital
2014-2024
Capital Medical University
2013-2024
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Dalian University
2021-2022
University of South China
2022
A cDNA clone for the complete coding sequence alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase V (GlcNAc-T V, EC 2.4.1.155) was isolated and expressed in COS-7 cells. Degenerate oligonucleotide primers polymerase chain reaction were synthesized based on amino acid of three tryptic peptides from affinity-purified GlcNAc-T V. Polymerase amplimers rat mouse mRNA. cDNA-encoding full-length enzyme a 1 cell (EJ-ras-transformed) library sequenced. Transient expression this...
Cervical cancer is among the most types, with an extremely high global incidence and mortality. Ferroptosis a newly reported programmed cell death process that differs from apoptosis, autophagy, necroptosis. Circular RNAs (circRNAs) are covalently closed loops generated back-splicing pre-mRNAs, stability, abundant in physical environment. Here, we explored effect of circACAP2 on ferroptosis cervical cancer. We observed depletion by siRNAs was validated cells. The viability inhibited...
Mucin 17 (MUC17), a transmembrane mucin, is overexpressed in pancreatic cancer and associated with tumor proliferation metastasis. CD3 an indispensable molecule on the surface of T lymphocytes, which cell activation participates immune responses. Here, we developed bispecific T-cell engager radiotracer, 89Zr-M17C3, targeting MUC17 CD3, to enable noninvasive PET imaging both cells infiltration cancer. 89Zr-M17C3 was synthesized by conjugating AMG199 zirconium-89 verified for its radiochemical...
To detect HOXD9 levels in cervical cancer species and to explore the relationship between level prognosis patients. We also verify influence of on metastatic abilities cancer.HOXD9 were detected. Its clinical features patients was analyzed. Regulatory effects migratory invasive capacities C33-A HeLa cells evaluated by Transwell assay. Subsequently, downstream gene predicted bioinformatics analysis confirmed luciferase The involvement HMCN1 regulating ability finally explored rescue...
Zonula occludens-1 (ZO-1) and occludin are important tight junction (TJ)-associated proteins, which expressed in the retinal pigment epithelium (RPE)-choroid complex. Retinoic acid (RA) is a regulator of eye growth may play an role forming functional TJs. The aim this study was to detect changes that occur expression ZO-1 RPE-choroid complex guinea pigs with lens-induced myopia (LIM), investigate effect RA on TJ-associated proteins vivo. We developed animal model by placing -6.00 D negative...
Abstract Papillary thyroid cancer (PTC) is a frequent malignancy. With the significant regulatory role in tumor progression, more attention has been employed to investigate mechanism of long noncoding RNAs (lncRNAs) progression PTC. We prospectively explored whereby lncRNA SET‐binding factor 2‐antisense RNA1 (SBF2‐AS1) implicated pathogenesis First, differentially expressed SBF2‐AS1 between PTC and normal adjacent tissues was determined, result indicated higher expression than tissues....
Nowadays, it is indicated that miRNA was anomaly expressed in tumour. Previous studies have shown miRNAs can regulate the proliferation, invasion, and migration of cancer cell-related processes. Meanwhile, current investigations show RAB23 also plays an important role But potential mechanism remains unclear.SW579 cells were selected transfected with miR-597-3p mimics. Then expression measured by quantitative real-time polymerase chain reaction (PCR) western blotting, respectively....
Interleukin-18 (IL18) gene polymorphisms are related to many inflammatory and autoimmune diseases. However, a correlation analysis between IL18 -607C/A -137G/C Takayasu arteritis (TA) is lacking.This study enrolled 200 patients with TA as the case group 334 region-, age-, sex-matched healthy subjects control group. We genotyped alleles genotypes at positions -607 -137 of analyzed distribution frequencies. Mann-Whitney U test, t Chi-squared test Hardy-Weinberg equilibrium were performed.After...
To explore the role of mechanical hemodynamic support (MHS) in mapping and catheter ablation patients with hemodynamically unstable ventricular tachycardia (VT), report single-center experience a cohort consecutive receiving VT during MHS therapy, provide evidence-based medical evidence for clinical practice.
Esophageal cancer (ESCA) has the sixth highest mortality rate worldwide and its incidence is increasing every year. Alterations in genes poor dietary habits may induce ESCA. In addition, tumor immune microenvironment one of most common factors involved tumorigenesis development ESCA, which be mediated by tumor-associated macrophages, but molecular mechanism underlying this unclear. Therefore, study, CIBERSORT was used to understand distribution innate-immune cells ESCA normal tissues using...
This study is to investigate the preventive and therapeutic effect of intraportal oridonin on colorectal cancer liver metastasis (CRCLM).The inhibitory HT29 cells was determined by CCK-8 MTT assays. The CRCLM were investigated establishing BALb/c nude mice hemispleen models colon metastasis. microscopic characteristics tumor tissues observed hematoxylin-eosin staining, immunohistochemistry TUNEL staining. On other hand, function enzymes, such as alanine aminotransferase (ALT), aspartate...