A5039991549- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Child Nutrition and Water Access
- Obstructive Sleep Apnea Research
- Birth, Development, and Health
- Sleep and related disorders
- Neuroscience of respiration and sleep
- Infant Development and Preterm Care
- Pregnancy and preeclampsia studies
- Maternal Mental Health During Pregnancy and Postpartum
- Material Dynamics and Properties
- Liquid Crystal Research Advancements
- Circadian rhythm and melatonin
- Dietary Effects on Health
- Menstrual Health and Disorders
- Breastfeeding Practices and Influences
- Maternal and Perinatal Health Interventions
- Surfactants and Colloidal Systems
- Family Support in Illness
- Sleep and Wakefulness Research
- Reproductive Health and Contraception
- Advanced Statistical Process Monitoring
- Polydiacetylene-based materials and applications
- Underground infrastructure and sustainability
- Optimal Experimental Design Methods
Walter and Eliza Hall Institute of Medical Research
2021-2025
The University of Melbourne
2022-2024
Cardiff University
2023
Pinsent Masons (United Kingdom)
2023
Kamuzu Central Hospital
2023
Peter Doherty Institute
2023
Peter MacCallum Cancer Centre
2023
The Royal Melbourne Hospital
2023
University of Otago
2017-2021
Murdoch Children's Research Institute
2021
A generic statistical mechanical model is presented for the self-assembly of chiral rod-like units, such as β-sheet-forming peptides, into helical tapes, which with increasing concentration associate twisted ribbons (double tapes), fibrils (twisted stacks ribbons), and fibers (entwined fibrils). The finite fibril width helicity shown to stem from a competition between free energy gain attraction penalty because elastic distortion intrinsically on incorporation growing fibril. Fibers are...
The birth of a child should be time celebration. However, for many women, childbirth represents great vulnerability to becoming mentally unwell, neglected maternal morbidity. This study aimed determine the prevalence early postpartum depression (PPD) and its associated risk factors among women giving at health facilities in southern Malawi. Identifying vulnerable PPD will help clinicians provide appropriately targeted interventions before discharge from maternity ward.We conducted nested...
Abstract Over 46% of African pregnant women are anemic. Oral iron is recommended but often suboptimal, particularly late in pregnancy. Intravenous ferric carboxymaltose (FCM) could treat anemia the third trimester sub-Saharan Africa. In an open-label, individually randomized trial antenatal clinics southern Malawi, we 590 at 27–35 weeks gestation with capillary hemoglobin <10.0 g dl −1 to FCM (20 mg kg up 1,000 mg, once enrollment) or standard care (60 elemental iron, twice daily for 90...
ABSTRACT: Objective: Sleep difficulties, daytime sleepiness, and sluggish cognitive tempo (SCT) are associated with impairments in academic performance. SCT refers to symptoms of sluggishness, tiredness/lethargy, slowed thinking/processing, but despite symptom overlap research examining interrelations sleep sleepiness is limited. The aims this study were evaluate the relationship between examine pathways sleep, SCT, Method: Participants a community sample 1628 parents/caregivers children...
Anaemia in pregnancy remains a critical global health problem, affecting 46% of pregnant women Africa and 49% Asia. Oral iron therapy requires extended adherence to achieve correction anaemia replenishment stores. Ferric carboxymaltose (FCM) is recently established intravenous formulation associated with substantial advantages safety, speed delivery total dose deliverable single infusion. We aim determine whether FCM given once during the second trimester compared standard oral distributed...
<ns4:p>Background Anemia affects 40% of pregnant women globally, leading to maternal mortality, premature birth, low birth weight, and poor baby development. Iron deficiency causes over anemia cases in Africa. Oral iron supplementation is insufficient for Low-and-Middle-Income-Countries (LMICs) meet current WHO targets. We hypothesized that a single intravenous dose Ferric Carboxymaltose (FCM) may be more effective than oral treatment recovery, particularly these settings where present late...
Abstract Serum iron has long been thought to exhibit diurnal variation and is subsequently considered an unreliable biomarker of systemic status. Circadian regulation (endogenous ~24‐h periodic oscillation a biologic function) governs many critical physiologic processes. It unknown whether serum levels are regulated by circadian machinery; likewise, the nature key players homeostasis unstudied. Here we show that iron, transferrin saturation (TSAT), hepatic receptor (TFR1) gene ( Tfrc )...
The liquid crystalline phase diagrams for aqueous solutions of the homologous series surfactants CF3(CF2)nCO−2Cs+ (n=5–8) have been determined. They all exhibit classical isotropic (I)-to-discotic nematic (ND) and ND-to-smectic lamellar (L) sequences transitions with increasing concentration, as previously established n=6 system [N. Boden, S. A. Corne, K. W. Jolley, J. Phys. Chem. 91, 4092 (1987)]. effect n is to displace higher temperatures. behavior surfactant systems can be represented on...
Background: Anaemia affects more than half of Africa's pregnancies. Standard care, with oral iron tablets, often fails to achieve results, compliance and gastrointestinal side-effects being a significant issue. In recent years, intravenous formulations have become safe, effective, quick administer, allowing the complete requirements pregnancy be provided in one 15-minute infusion. The Randomized controlled trial Effect intraVenous on Malawian Pregnant women (REVAMP) will evaluate whether...
Research Findings: Optimal sleep is important for children's learning and development. Sleep disordered breathing (SDB) refers to a spectrum of conditions from simple snoring obstructive apnea that common in childhood interrupts sleep. We examined pathways between SDB academic performance children (N = 163, M age 6.2 years) one year after school entry. Measures included parent questionnaire clinical assessment SDB, standardized tests rating scales cognitive executive functioning,...
Abstract Children born extremely preterm (EP, <28 weeks’ gestation) or low birth weight (ELBW, <1,000 g) are a vulnerable population at high risk of working memory impairments. We aimed to examine changes in the brain structural connectivity networks thought underlie performance, after completion training program (Cogmed) compared with placebo EP/ELBW children. This was double‐blind, placebo‐controlled randomized trial (the Improving Memory Preterm Randomised Intervention Trial)....
Background: Childhood sleep disordered breathing (SDB) has been linked to poorer academic performance; however, research not investigated the extent improvement in SDB may alter outcomes across key skills. This study aimed investigate if children's early status could predict later outcomes, and an childhood years would coincide with better, performance skills related reading, numeracy, listening comprehension. Methods: Eighty five case children symptom score &gt;25 (maximum 77) were...
<ns4:p><ns4:bold>Background: </ns4:bold>Anaemia affects more than half of Africa’s pregnancies. Standard care, with oral iron tablets, often fails to achieve results, compliance and gastrointestinal side-effects being a significant issue. In recent years, intravenous formulations have become safe, effective, quick administer, allowing the complete requirements pregnancy be provided in one 15-minute infusion. The Randomized controlled trial Effect intraVenous on Anaemia Malawian Pregnant...
Summary Background Menstrual-related absenteeism from work, school, or social activities is an important functional indicator of poor menstrual health that disrupts women and girls’ daily lives exacerbates gender inequality. We sought to estimate the prevalence factors contributing menstrual-related across low- middle-income countries (LMICs). Methods analysed cross-sectional data 47 nationally representative Multiple Indicator Cluster Surveys 2017-2023 comprising 3,193,042 individuals...
Abstract Serum iron has long been thought to exhibit diurnal variation and is subsequently considered an unreliable biomarker of systemic status. Circadian regulation (endogenous ∼24-hour periodic oscillation a biologic function) governs many critical physiologic processes. It unknown whether serum levels are regulated by circadian machinery; likewise, the nature key players homeostasis unstudied. Here we show that iron, hepatic transferrin receptor (TFR1) gene ( Tfrc ) expression...
The current constraints on skills and knowledge across the infrastructure sector how to set up, structure procure digital solutions at each stage of asset life cycle need be rapidly overcome allow climate change targets achieved. Digital data sharing must given a high priority, with operating models developed funded as part overall resourcing, procurement contracting process for assets. This paper summarises some practical, structural legal considerations that enable – particularly building...