A5026776988- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Olfactory and Sensory Function Studies
- Iron Metabolism and Disorders
- Memory and Neural Mechanisms
- Hemoglobinopathies and Related Disorders
- Neuroscience and Neuropharmacology Research
- Biochemical Analysis and Sensing Techniques
- Kruppel-like factors research
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Child Nutrition and Water Access
- Animal Nutrition and Physiology
- Platelet Disorders and Treatments
- Protease and Inhibitor Mechanisms
- Diabetes Treatment and Management
- Circadian rhythm and melatonin
- Trace Elements in Health
- Dietary Effects on Health
- Gut microbiota and health
- Peptidase Inhibition and Analysis
- Pancreatic function and diabetes
- Advanced Proteomics Techniques and Applications
- Language and cultural evolution
- Language Development and Disorders
- Reproductive System and Pregnancy
Walter and Eliza Hall Institute of Medical Research
2018-2025
The University of Melbourne
2019-2024
University of Cambridge
1999-2022
National Health Service
2012-2022
NHS Blood and Transplant
2013-2022
KU Leuven
2015
Maastricht University
2015
Synapse (Netherlands)
2015
University of Bristol
2015
Upon activation, platelets release a powerful cocktail of soluble and vesicular signals, collectively termed the "platelet releasate" (PR). Although several studies have used qualitative/quantitative proteomic approaches to characterize PR; with debated content significant inter-individual variability reported, confident, reliable insights been hindered. Using label-free quantitative (LFQ)-proteomics analysis, reproducible, quantifiable investigation 1U mL-1 thrombin-induced PR from 32...
Objective— Platelets are increasingly implicated in processes beyond hemostasis and thrombosis, such as vascular remodeling. Members of the matrix metalloproteinase (MMP) family not only remodel extracellular but also modulate platelet function. Here, we made a systematic comparison roles MMP members acute thrombus formation under flow conditions assessed platelet-dependent collagenolytic activity over time. Approach Results— Pharmacological inhibition MMP-1 or MMP-2 (human) deficiency...
Abstract Antibiotics may alter the gut microbiome, and this is one of mechanisms by which antimicrobial resistance be promoted. Suboptimal stewardship in Asia has been linked to resistance. We aim examine relationship between oral antibiotic use composition microbiome 1093 Bangladeshi infants. leverage a trial 8-month-old infants rural Bangladesh: 61% children were cumulatively exposed antibiotics (most commonly cephalosporins macrolides) over 12-month study period, including 47% first 3...
To determine efficacy and tolerability of dutogliptin, a dipeptidyl peptidase 4 (DPP4) inhibitor, in patients with type 2 diabetes mellitus.This was 12-week, multicentre, randomized, double-blind, placebo-controlled trial 423 suboptimal metabolic control. Following 2-week single-blind placebo run-in, aged 18-75 years body mass index 25-48 kg/m(2) baseline HbA1c 7.3-11.0% were randomized 2:2:1 to receive once-daily oral therapy either dutogliptin (400 or 200 mg) on background medication...
The process of platelet production has so far been understood to be a 2-stage process: megakaryocyte maturation from hematopoietic stem cells followed by proplatelet formation, with each phase regulating the peripheral blood count. Proplatelet formation releases into bloodstream beads-on-a-string preplatelets, which undergo fission mature platelets. For first time, we show that preplatelet is third, tightly regulated, critical akin cytokinesis regulates We deficiency in cytokine...
In each of two experiments, rats were pre-exposed to flavoured solutions, saline-lemon and sucrose-lemon. For group ALT, trials with one solution alternated the other. Group BLK received all in a block, before any An associative theory suggests that alternating, but not blocked, schedule would establish an inhibitory association between sucrose saline. To provide retardation test this inhibition, some animals then given single pairing saline sucrose, experienced sodium depletion, finally...
In a series of flavour aversion experiments, rats received different schedules pre-exposure to two compound flavours (AX and BX). Discrimination between them was assessed by establishing an AX measuring generalization this BX. Experiment 1 demonstrated that alternating BX resulted in less than did blocked exposure, where animals all exposure before (or vice versa). This difference not accompanied any the strength conditioned common X element. Varying interval condition from minute or several...
Aim: To determine the efficacy and tolerability of PHX1149, a novel dipeptidyl peptidase‐4 (DPP4) inhibitor, in patients with type 2 diabetes. Methods: This is multicentre, randomized, double‐blind, placebo‐controlled, 4‐week study diabetes suboptimal metabolic control. Patients baseline haemoglobin A 1c (HbA ) 7.3 to 11.0% were randomized 1 : receive once‐daily oral therapy either PHX1149 (100, 200 or 400 mg) placebo; on constant background metformin alone plus glitazone. Results: Treatment...
Polycythemia Vera (PV) is a myeloproliferative neoplasm driven by activating mutations in JAK2 that result unrestrained erythrocyte production, increasing patients' hematocrit and hemoglobin concentration, placing them at risk of life-threatening thrombotic events. Our GWAS 440 PV cases 403,351 controls utilizing UK Biobank data found SNPs HFE known to cause hemochromatosis are highly associated with diagnosis, linking iron regulation PV. Analysis the FinnGen dataset independently confirmed...
Rats injected with lithium chloride after drinking a saline-lemon solution also reduced their consumption of and sucrose-lemon, but single prior exposure to sucrose-lemon decreased the generalized aversion. Experiment 1 showed that this decrease in aversion could not be explained by either conditioned or neophobia sucrose-lemon. 2 ruled out possibility generalization between was based on shared novelty. 3 two solutions related strength lemon flavor they common causing latent inhibition element.
Abstract Serum iron has long been thought to exhibit diurnal variation and is subsequently considered an unreliable biomarker of systemic status. Circadian regulation (endogenous ~24‐h periodic oscillation a biologic function) governs many critical physiologic processes. It unknown whether serum levels are regulated by circadian machinery; likewise, the nature key players homeostasis unstudied. Here we show that iron, transferrin saturation (TSAT), hepatic receptor (TFR1) gene ( Tfrc )...
Abstract Anemia is highly prevalent globally, especially in young children low-income countries, where it often overlaps with a high burden of diarrheal disease. Distribution iron interventions (as supplements or iron-containing multiple micronutrient powders, MNPs) key anemia reduction strategy. Small studies Africa indicate may reprofile the gut microbiome towards pathogenic species. We seek to evaluate safety and MNPs based on their effects diversity, composition, function rural...