A5103032877- Second Language Learning and Teaching
- Platelet Disorders and Treatments
- EFL/ESL Teaching and Learning
- Blood Coagulation and Thrombosis Mechanisms
- Reflective Practices in Education
- Innovations in Educational Methods
- Extracellular vesicles in disease
- Inflammatory Biomarkers in Disease Prognosis
- COVID-19 and Mental Health
- Educational Technology in Learning
- COVID-19 and healthcare impacts
- Healthcare professionals’ stress and burnout
- Wnt/β-catenin signaling in development and cancer
- Advanced Proteomics Techniques and Applications
- Phonetics and Phonology Research
- Higher Education Teaching and Evaluation
- Protease and Inhibitor Mechanisms
- Heparin-Induced Thrombocytopenia and Thrombosis
- Multiple Sclerosis Research Studies
- Cultural Insights and Digital Impacts
- Evaluation of Teaching Practices
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood properties and coagulation
- Online and Blended Learning
- Animal Behavior and Welfare Studies
University College Dublin
2017-2025
Laboratoire de Linguistique et Didactique des Langues Etrangères et Maternelles
2024
Université Grenoble Alpes
2024
Hannan University
2019-2021
South London and Maudsley NHS Foundation Trust
2021
King's College Hospital
2021
King's College London
2021
Royal College of Surgeons in Ireland
2018
University of Reading
2011
Objectives This study reports preliminary findings on the prevalence of, and factors associated with, mental health well-being outcomes of healthcare workers during early months (April–June) COVID-19 pandemic in UK. Methods Preliminary cross-sectional data were analysed from a cohort (n=4378). Clinical non-clinical staff three London-based NHS Trusts, including acute took part an online baseline survey. The primary outcome measure used is presence probable common disorders (CMDs), measured...
ABSTRACT Extracellular vesicles (EVs) are mediators of cell communication during health and disease, abundantly released by platelets upon activation or ageing. Platelet EVs exert modulatory effects on immune vascular cells. may modulate the function smooth muscle cells (SMC). were isolated from platelet‐rich plasma incubated with SMC in order to assess binding, proliferation, migration pro‐inflammatory phenotype firmly bound resting through platelet integrin α IIb β 3 , while binding also...
Upon activation, platelets release a powerful cocktail of soluble and vesicular signals, collectively termed the "platelet releasate" (PR). Although several studies have used qualitative/quantitative proteomic approaches to characterize PR; with debated content significant inter-individual variability reported, confident, reliable insights been hindered. Using label-free quantitative (LFQ)-proteomics analysis, reproducible, quantifiable investigation 1U mL-1 thrombin-induced PR from 32...
Nanoparticle tracking analysis (NTA) can be used to quantitate extracellular vesicles (EVs) in biological samples and is widely considered a useful diagnostic tool detect disease. However, accurately profiling EVs challenging due their small size heterogeneity. Here, we aimed provide protocol facilitate high-precision particle quantitation by NTA plasma, the supernatant of activated purified platelets (the platelet releasate) serum, increase confidence enumeration. The overall variance...
ABSTRACT Purpose Multiple Sclerosis is an inflammatory neurodegenerative disease characterised by blood‐brain barrier dysfunction and leukocyte infiltration into the CNS. Platelets are best known for their contributions to haemostasis, however, upon activation, platelets release abundance of soluble vesicular‐associated proteins, termed platelet releasate (PR). This milieu contains numerous vasoactive that can attract leukocytes alter endothelial permeability. Experimental design We aimed...
The safety, quality and supply of donor-derived platelet units intended for transfusion have improved over the past decades but significant problems still remain. In vitroderived platelets offer a possible alternative up-scaling production is hindered by our limited understanding thrombopoiesis (the release their mother cell, megakaryocyte [MK]). Here, we developed an integrated strategy aiming to mimic ex vivo bone marrow physiological niche that promotes mature MKs. screening panel 259...
Abstract Objectives This study reports preliminary findings on the prevalence of, and factors associated with, mental health wellbeing outcomes of healthcare workers during early months (April-June) COVID-19 pandemic in UK. Methods Preliminary cross-sectional data were analysed from a cohort (n=4,378). Clinical non-clinical staff three London-based NHS Trusts (UK), including acute Trusts, took part an online baseline survey. The primary outcome measure used is presence probable common...
Diabetic nephropathy is the most common microvascular complication of diabetes mellitus, manifesting as mesangial expansion, glomerular basement membrane thickening, sclerosis, and progressive tubulointerstitial fibrosis leading to end-stage renal disease. Here we describe functional characterization Wnt6, whose expression progressively lost in diabetic animal models acute tubular injury fibrosis. We have shown prominent Wnt6 frizzled 7 (FzD7) mesonephros developing mouse kidney, suggesting...
Upon activation, platelets release a host of soluble and vesicular signals, collectively termed the 'platelet releasate' (PR). The contents this PR play significant role in haemostasis, inflammation, pathologic sequelae. Despite this, proteomic studies investigating coronary artery disease have not been performed. Here, we undertook comparative label-free quantitative (LFQ) profiling 1U/ml thrombin-induced from 13 acute syndrome versus 14 stable angina pectoris patients using tandem mass...
Purpose Healthy pregnancy is characterized by an increase in platelet activation and a decrease the number of circulating platelets with gestation. Despite this recognized importance, proteomic studies investigating healthy have not been performed. As cargo can be altered different conditions, it hypothesized that may store relevant bespoke collection molecules during pregnancy. Experimental design Comparative label‐free quantitative profiling releasates (PRs) performed from 18 pregnant 13...
Background Thrombin is well recognised for its role in the coagulation cascade but it also plays a inflammation, with enhanced thrombin generation observed several inflammatory disorders. Although patients multiple sclerosis (MS) have higher incidence of thrombotic disease, has not been studied to date. Objectives The aim this study was characterise calibrated automated thrombography parameters relapsing–remitting MS (RRMS) and primary progressive (PPMS) comparison healthy controls (HCs)....
Abstract It was previously demonstrated that the WNT/β‐catenin pathway is present and active in platelets established canonical WNT ligand, WNT‐3a, suppresses platelet adhesion activation. In nucleated cells, β‐catenin, key downstream effector of this pathway, a dual function protein, regulating coordination gene transcription cell–cell adhesion. The specific role β‐catenin anucleate however remains elusive. Here, label‐free quantitative proteomic analysis immunoprecipitates from human...
The optimum assessment structure measures student knowledge accurately and without bias. In this study, the performance of first-year undergraduate science students from University College Dublin was evaluated to test gender equality in place. Results male female taking three life modules were analysed, for two academic years, with based on a combination types evaluation: continuous multiple choice questions (MCQ) exam scored with/without negative marking. We found no significant effect...