A5090107780- Comparative Animal Anatomy Studies
- Polysaccharides Composition and Applications
- Nanocomposite Films for Food Packaging
- Research on Leishmaniasis Studies
- Polysaccharides and Plant Cell Walls
- Liver Disease Diagnosis and Treatment
- Urological Disorders and Treatments
- Congenital Diaphragmatic Hernia Studies
- Antioxidant Activity and Oxidative Stress
- Tracheal and airway disorders
- Eicosanoids and Hypertension Pharmacology
- Public Health in Brazil
- Vector-Borne Animal Diseases
- Infant Nutrition and Health
- Pediatric Hepatobiliary Diseases and Treatments
- Fatty Acid Research and Health
- Neonatal Respiratory Health Research
- Psidium guajava Extracts and Applications
- Bone Tissue Engineering Materials
- Hydrogels: synthesis, properties, applications
- Cardiovascular Disease and Adiposity
- Maternal and Neonatal Healthcare
- Virus-based gene therapy research
- Intestinal Malrotation and Obstruction Disorders
- Breastfeeding Practices and Influences
Universidade Federal do Piauí
2016-2025
Universidade de São Paulo
1999-2023
Universidade Católica Portuguesa
2023
Universidade Estadual de Maringá
2023
Morpho (United States)
2015-2016
University of Campania "Luigi Vanvitelli"
2003
Clínica Santa María
1983
University of Florence
1981
Herein, a nanocomposite hydrogel was produced using laponite and polyethylene-glycol diacrylate (PEGDA), with or without Irgacure (IG), for application in bone tissue regeneration. The nanocomposites were characterized by X-ray diffraction (XRD), Fourier-Transform infrared spectroscopy (FTIR), thermal analysis (TG/DTG). XRD results showed that the crystallographic structure of preserved hydrogels after incorporation PEGDA IG. FTIR indicated polymer chains entangled on hydrogels. TG/DTG found...
The development of anticancer drugs is costly and time intensive. Computational approaches optimize the process by studying molecules such as naphthoquinones. This research explores quantitative structure–activity relationship (QSPR) molecular interactions among 2,2-dimethyl-3-((3-nitrophenyl)amino)-2,3-dihydronaphtho[1,2-b]furan-4,5-dione (QPhNO2), a Nor-β-Lapachone derivative with properties, following polymers for nanoencapsulation: polymethyl methacrylate (PMMA), polycaprolactone (PCL),...
The buriti oil (Mauritia flexuosa L.) can be associated with polymeric matrices for biomedical applications. This study aimed to evaluate the effect of chitosan gel (CG) (CGB) as a healing agent. fatty acids and volatile compounds composition were performed composite gels characterized using FTIR thermal analysis. Biological tests including antimicrobial, antioxidant, anti-inflammatory effects also investigated. Buriti is composed oleic palmitic acids, main identified. did not show...
Chicha gum is a natural polymer obtained from the Sterculia striata plant. The hydroxyl groups of its structure have chemical affinity to form hydrogels, which favors association with biologically active molecules, such as nerolidol. This improves biological properties and allows material be used in drug delivery systems. hydrogels associated nerolidol were produced at two concentrations: 0.01 0.02 g mL−1. Then, characterized by thermogravimetry (TG), Fourier Transform Infrared spectroscopy...
In this study, we demonstrated the potential associative effect of combining conventional amphotericin B (Amph B) with gallic acid (GA) and ellagic (EA) in topical formulations for treatment cutaneous leishmaniasis BALB/c mice. Preliminary stability tests vitro drug release studies Amph B, GA, plus EA, EA were carried out, as well assessment vivo mice infected Leishmania major After 40 days infection, animals divided into 6 groups treated twice a day 21 gel containing or negative-control...
Abstract Aim To evaluate the biocompatibility of two pastes designed to fill root canals primary teeth. Methodology A study group 54 mice received subcutaneous tissue implants polyethylene tubes containing CTZ or calcium hydroxide paste or, as a negative control, empty tubes. Biocompatibility was evaluated on days 7, 21 and 63, yielding total nine groups six animals each. Following experimental intervals, implant areas were removed subjected histologic processing. After tissues stained with...
Wounds are considered a clinically critical issue, and effective treatment will decrease complications, prevent chronic wound formation, allow rapid healing. The development of products based on naturally occurring materials is an efficient approach to Natural polysaccharides can mimic the extracellular matrix promote cell growth, thus making them attractive for In this context, aim work was produce gel chicha gum, chitosan, Mauritia flexuosa oil (CGCHO) treatment. TG DTG analyzed thermal...
This work assessed the effects of a 28-day treatment with lycopene-rich extract (LRE) from red guava fruit (Psidium guajava L.) on lipid profile and oxidative stress in an experimental model dyslipidemia. Male hamsters (116.5 ± 2.16 g) were fed AIN 93G diet containing casein (20%), coconut fat (13.5%) cholesterol (0.1%). The animals divided into four groups: normolipidemic control (standard feed; NC, n = 7); hypercholesterolemic (HC, LRE 25 mg/kg/day (LRE-25, 7) 50 (LRE-50, 9). After...
Galactomannans are versatile macromolecules with broad industrial potential. The influence of changes in the chemical structures and respective bioactivities these polysaccharides have been extensively studied. derivatives obtained by sulfation, complexation, phosphorylation most studied biological properties galactomannans. shown several pharmacological activities such as antiviral, antimicrobial, anticoagulant, fibrinolytic, chemopreventive, anticancer, antioxidant, chondroprotective,...
Mauritia flexuosa L., traditionally known as “buriti”, exhibits chemoprotective properties including antioxidant, antithrombotic, and nutritional actions. The aim of this study was to examine the oral anti-inflammatory activity epicarp, mesocarp endocarp obtained from M. fruits using in vivo models verify physiological benefits. anti-edematogenic action determined phlogistic agents induce paw edema peritonitis. Pro-inflammatory cytokines, cell migration peritoneal cells, histological...
Abstract Biomaterials used in tissue regeneration processes represent a promising option for the versatility of its physical and chemical characteristics, allowing assisting or speeding up repair process stages. This research has characterized polyurethane produced from castor oil monoacylglyceride ( Ricinus communis L) tested effect on reconstructing bone defects rat calvaria, comparing it with commercial polyurethane. The characterizations synthesized have been performed by spectroscopy...
This study aimed to evaluate the effects of treatment with bacuri seed butter (BB) on body weight, growth, mass index, lipid profile, atherosclerotic indices, and liver function in dyslipidemic hamsters. Freshly weaned, male hamsters were divided into four groups: (1) normal group (NG)-maintained standard chow (AIN-93G); (2) dyslipidemia (DG)-maintained hyperlipidemic (AIN-93G modified) throughout follow-up period; (3) 25 mg/kg/day (BB-25); (4) 50 (BB-50). BB groups (25 mg/kg/day) also...
Atherosclerosis is a cardiovascular disease associated with abnormalities of vascular functions. The consumption mono- and polyunsaturated fatty acids can be considered strategy to reduce clinical events related atherosclerosis. In the present study, we investigated effects supplementation 310 mg ω-3 PUFAs (2:1 eicosapentaenoic/docosahexaenoic acids) for 56 days on rats hypercholesterolemia induced by diet containing cholesterol (0.1%), cholic acid (0.5%), egg yolk. Serum biochemical...
This study aims to evaluate the hepatoprotective, hypolipidemic and aortic morphometric effects of fish oil rich in omega-3 hypercholesterolemic BALB/c mice. is an experimental model that included 16 male mice (Mus musculus) divided into three groups (G1 (standard commercial chow 0.9% saline solution), G2 (hypercholesterolemic diet solution) G3 oil)) for 8 weeks. There was no significant difference treatment with omega-3-rich lipid profile (p > 0.05). In histological analysis, group...
Objetivo: Estimar as interações medicamentosas potenciais (IMPs) a partir de prescrições médicas para indivíduos maiores 18 anos, diagnosticados com hipertensão arterial sistêmica (HAS) e/ou diabetes mellitus (DM), em uma unidade pronto atendimento. Métodos: Estudo quantitativo, do tipo documental, descritivo e retrospectivo, realizado auxílio da Drug Interaction Checker DrugBank avaliação estratificação das IMPs. Resultados: 58,2% dos pacientes atendidos apresentavam 60 anos ou mais, maior...
Biopolymers are widely distributed in nature and have a wide variety of biological properties applications. Chia (Salvia hispanica L.) is an herbaceous plant that belongs to the Lamiaceae family, which when contact with water exude fraction soluble fiber form mucilage. In view above, this study aims provide overview characteristics applications chia mucilage make it biopolymer industrial interest. The data collection was carried out databases: SciELO (Scientific Electronic Library Online),...