Tantalum-oxide-based bi-layered resistance-change memories (RRAMs) have recently improved greatly with regard to their memory performances. The formation and rupture of conductive filaments is generally known be the mechanism that underlies resistive switching. nature filament has been studied intensively several phenomenological models consistently predicted behavior. However, a physics-based model describes complete RRAM structure not yet demonstrated. Here, electro-thermal switching based...

The present study was carried out to evaluate the promising potential of polymers and oligomers from proanthocyanidins persimmon peel as antioxidants therapeutic agents for diabetes. Both showed scavenging effect 2,2-diphenyl-l-picrylhydrazyl, with IC50 values 4.35 2.41 microg/mL, respectively, they also a protective activity against protein oxidation induced by 2,2'-azobis (2-amidinopropane) dihydrochloride. In particular, exerted stronger free radicals than polymers. addition, investigate...

Abstract Protein disulfide isomerase (PDI) oxidizes, reduces, and isomerizes bonds, modulates redox responses, chaperones proteins. The Arabidopsis thaliana genome contains 12 PDI genes, but little is known about their subcellular locations functions. We demonstrate that PDI5 expressed in endothelial cells to undergo programmed cell death (PCD) developing seeds. interacts with three different Cys proteases yeast two-hybrid screens. One of these traffics together from the endoplasmic...

This study was carried out to investigate the protective potential of Chinese prescription Kangen-karyu, comprising six crude drugs, on coronary heart disease which is principal cause morbidity and mortality worldwide. The diet-induced hypercholesterolemic rat model, shows an elevation in low density lipoprotein (LDL) cholesterol atherosclerosis, employed. control rats fed a diet 1% 0.5% cholic acid showed highest levels serum feces relative those normal diet, however, administered...

Alzheimer's disease (AD) is characterized by deficits in memory and cognitive functions. The accumulation of amyloid beta peptide (Aβ) oxidative stress the brain are most common causes AD. Caffeic acid (CA) an active phenolic compound that has a variety pharmacological actions. We studied protective abilities CA Aβ25-35-injected AD mouse model. was administered at oral dose 10 or 50 mg/kg/day for 2 weeks. Behavioral tests including T-maze, object recognition, Morris water maze were carried...

We investigated the protective effect and mechanisms of apigenin against cognitive impairments in a scopolamine-injected mouse model. Our results showed that intraperitoneal (i.p.) injection scopolamine leads to learning memory dysfunction, whereas administration (synthetic compound, 100 200 mg/kg/day) improved ability, which was confirmed by behavioral tests such as T-maze test, novel objective recognition Morris water maze test mice. In addition, scopolamine-induced lipid peroxidation...

This study investigated the antioxidative activity of green tea extract, and a tannin mixture its components, under conditions radical generation using hydrophilic azo compound, 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH) to generate peroxyl radicals at constant measurable rate in cultured renal epithelial cell line, LLC-PK(1), which is susceptible oxidative damage. Treatment with AAPH decreased viability increased formation thiobarbituric acid-reactive substances. However,...

Among the various theories of aging process, free radical theory, which proposes that deleterious actions radicals are responsible for functional deterioration associated with aging, has received widespread attention. The theory suggests enhancement antioxidative defence system to attenuate free-radical-induced damage will counteract process. We used senescence-accelerated mice (SAM) investigate relationship between and evaluated effects ginsenoside-Rd, saponin from ginseng, by measuring...

The protective effect of proanthocyanidins from persimmon peel, using both oligomers and polymers, was investigated in a db/db type 2 diabetes model. Male mice were divided into three groups: control (vehicle), polymer-, or oligomer- (10 mg/(kg body weight x day p.o.)) administered mice. Age-matched nondiabetic m/m used as normal group. administration reduced hyperglycemia through decline the serum level glucose glycosylated protein. In addition, it had strong on hyperlipidemia lowering...

Methionine residues of proteins are a major target for oxidation by reactive oxygen species (ROS), which generated in response to variety stress conditions. sulfoxide (MetO) reductases present most organisms and play protective roles the cellular oxidative stress, reducing oxidized MetO back Met. Previously, an Arabidopsis reductase, MsrB3, was identified as cold-responsive protein. Here we report that MsrB3 functions process cold acclimation, thus contributing tolerance. In contrast normal,...

Cholinergic dysfunction and oxidative stress are the most common causes of Alzheimer's disease (AD). Safflower seed contains various anti-oxidant cholinergic improvement compounds, such as serotonin its derivatives. In present study, we investigated protective effects mechanisms a safflower extract on scopolamine-induced memory impairment in mouse model. The was orally administered at dose 100 mg kg-1 day-1, then behavior tests (such T-maze novel object recognition tests) were conducted....

This study aims to investigate the protective effects and mechanisms of pectolinarin against oxidative stress-induced cell damage in SH-SY5Y cells. Neurodegenerative diseases-such as Alzheimer's disease-are potentially associated with stress, which causes excessive production reactive oxygen species (ROS) that DNA proteins neuronal The results this demonstrate can scavenge hydroxyl nitric oxide radicals a concentration-dependent manner. Moreover, significantly increased viability while...

The antioxidative activities of 12 medicinal plants and the compounds isolated from them were investigated using thiocyanate method to evaluate inhibitory effects on lipid peroxidation in linoleic acid system. peroxide levels gradually increased during incubation presence over 3 days, most inhibited peroxidation. In particular, tested, Cudrania tricuspidata, Zanthoxylum piperitum, Houttuynia cordata Ulmus parvifolia reduced more effectively as progressed, resulting inhibition about 80%...

To investigate the effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside (isorhamnetin diglucoside), a major flavonoid compound mustard leaf, on oxidative stress due to diabetes mellitus, in vivo and vitro studies were carried out. Oral administration diglucoside (10 or 20 mg/kg body weight/day for 10 days) rats with streptozotocin-induced significantly reduced serum levels glucose 5-(hydroxymethyl)furfural (5-HMF), which is glycosylated hemoglobin an indicator stress. After...

We have investigated the protective effects of Coptidis Rhizoma against peroxynitrite (ONOO(-))-induced oxidative damage and elucidated active components this preparation. In an in-vitro system, extract scavenged ONOO(-) its precursors, nitric oxide (NO) superoxide anion (O(2)(-)). This scavenging activity was more marked for than precursors. addition, 3-morpholinosydnonimine-induced cellular damage, significantly reduced formation increased cell viability. in-vivo lipopolysaccharide plus...

Recent evidence strongly suggests that oxidative stress due to redox imbalance is causally associated with inflammatory processes and various diseases including diabetes. We examined the effects of proanthocyanidin from persimmon peel, using both oligomers polymers, against elucidation underlying mechanisms in streptozotocin-induced diabetic rats. The elevation lipid peroxidation kidney serum under condition was decreased by administration proanthocyanidin. suppression reactive oxygen...

8-Hydroxy-2'-deoxyguanosine (8-OHdG), one of the most abundant oxidative DNA adducts, is used as an indicator damage associated with aging. Among homologs silent information regulator (Sir), sirtuin 1 (SIRT1) suggested a apoptotic response to damage. Since it has been that aging process can be delayed by attenuation such or SIRT1 modulation, we focused on protective effect against cellular persimmon peel, proanthocyanidin-rich food, in relation its level polymerization. We confirmed 8-OHdG...

We investigated the antidiabetic potential of proanthocyanidin and its oligomeric form in STZ-induced diabetic model rats db/db type 2 mice. Proanthocyanidin ameliorated condition by significant decreases serum glucose, glycosylated protein, urea nitrogen as well urinary protein renal-AGE decrease glucose The suppression ROS generation elevation GSH/GSSG ratio were also observed groups administered proanthocyanidin. Moreover, proanthocyanidin, especially form, affected inflammatory process...