A5101948861- Protein Hydrolysis and Bioactive Peptides
- Microbial Community Ecology and Physiology
- Retinal Development and Disorders
- Genomics and Phylogenetic Studies
- Meat and Animal Product Quality
- Plant biochemistry and biosynthesis
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Biopolymer Synthesis and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Probiotics and Fermented Foods
- Peroxisome Proliferator-Activated Receptors
- Calpain Protease Function and Regulation
- Genetic Syndromes and Imprinting
- Fungal Biology and Applications
- Single-cell and spatial transcriptomics
- Erythrocyte Function and Pathophysiology
- Mechanisms of cancer metastasis
- Aluminum toxicity and tolerance in plants and animals
- Genetics and Physical Performance
- Biochemical and biochemical processes
- Connexins and lens biology
- Retinal Diseases and Treatments
- Nuclear Receptors and Signaling
Institute of Botany
2023-2025
Nantong University
2021-2022
Microbiology Institute of Shaanxi
2020
Institute of Microbiology
2020
Chinese Academy of Sciences
2020
Henan Cancer Hospital
2019
Nanjing Agricultural University
2017-2018
Shanghai Clinical Research Center
2017
Ruijin Hospital
2014-2017
Shanghai Jiao Tong University
2017
Abstract Taxonomic and functional research of microorganisms has increasingly relied upon genome-based data methods. As the depository Global Catalogue Microorganisms (GCM) 10K prokaryotic type strain sequencing project, Type Strain (gcType) published 1049 genomes sequenced by GCM project which are preserved in global culture collections with a valid status. Additionally, information provided through gcType includes >12 000 publicly available genome sequences from GenBank incorporated...
One approach to gaining insight into the biological pathways contributing rod and cone photoreceptor death is identify patterns of gene expression changes. In present study, a custom retinal microarray was developed analyze rd1 mouse, well-characterized animal model human degeneration.A constructed containing cDNA fragments corresponding genes known or postulated be involved in normal function, development, disease. Gene retina compared with age-matched control retinas at three time points:...
Despite evidence that differences in gene expression levels contribute significantly to phenotypic variation across individuals, there has been only limited effort study human tissue. To characterize the normal retina, we utilized a custom retinal microarray analyze 33 retinas from 19 donors, aged 29-90 years. Statistical models were designed separate and quantify biological technical sources of variation, including age, gender, eye laterality, function age-by-gender interaction. Although...
Summary Aims To investigate the roles of N‐myc downstream‐regulated gene 2 ( NDRG 2) in pathology aging and neurodegenerative disease such as Alzheimer's AD ). Results In this study, we confirmed upregulation brains animal models. explore role at molecular level, conducted a cell‐based assay highly expressed wild‐type human APP 695 SK ‐N‐ SH cells wt). By silencing overexpressing 2, demonstrated that 2‐mediated increase Aβ 1‐42 was through pathways BACE 1 GGA 3. NGRG improved tau...
Bone is an endocrine organ involved in modulating glucose homeostasis. The role of the bone formation marker osteocalcin (OCN) predicting diabetes was reported, but with conflicting results. No study has explored association between baseline resorption activity and incident or prediabetes during follow-up. Our objective to examine relationship crosslinked C-telopeptide type I collagen (CTX) glycemic dysregulation after 4 years. This longitudinal conducted a university teaching hospital. A...
Tumor necrosis factor-alpha (TNF-alpha) is a potent catabolic factor to skeletal muscle. Single-nucleotide polymorphisms (SNPs) in the promoter region of TNF-alpha coding gene, TNF, have been implicated interindividual variation production via transcriptional regulation. The present study investigated association muscle phenotypes with five TNF SNPs, which potentially biological significance. Female and male volunteers (n = 1,050) from Baltimore Longitudinal Study Aging were genotyped, their...
The objective of this study was to investigate changes in flavor components broth prepared by pork ribs that were aged for 1 d, 3 and 7 d. contents free amino acids (FAAs), nucleic acid-related compounds, organic acids, volatile compounds measured. overall taste aroma profiles evaluated electronic tongue, nose, sensory panelists. results showed the FAAs succinic acid increased, while 5ʹ-guanosine monophosphate, 5ʹ-inosine 5ʹ-adenosine monophosphate decreased as aging time increased. These...
A novel bacterial strain, designated SYL130T, was isolated from the sewage sediment of a park in Busan, Korea. The strain aerobic, producing orange colonies on R2A agar. Cells were single, Gram-stain-negative rods and motile by gliding. Phylogenetic analyses, based 16S rRNA gene sequences, showed that SYL130T most closely related to Sediminibacterium aquarii JCM 31013T (96.1 %). major fatty acids (>5 % total) iso-C15 : 0 (28.3 %), 1 G (23.2 iso-C17 3-OH (9.6 anteiso-C15 (5.9 %) iso-C16 (5.6...
Prostate cancer (PCA) is one of the most common male genitourinary tumors. However, molecular mechanisms involved in occurrence and progression PCA have not been fully clarified. The present study aimed to investigate biological function mechanism nuclear receptor peroxisome proliferator-activated gamma 2 (PPARG2) PCA. Our results revealed that PPARG2 was downregulated PCA, overexpression inhibited cell migration, colony formation, invasion induced cycle arrest cells vitro. In addition,...
A Gram-stain-negative, strictly aerobic, non-motile, yellow, rod-shaped bacterium, designated strain E62-3T, was isolated from soil of Enshi Grand Canyon, Hubei province, PR China. Phylogenetic analysis based on 16S rRNA gene sequences showed that E62-3T most closely related to Sphingomonas laterariae LNB2T. Strain exhibited the highest sequence similarity Sphingosinicella vermicomposti YC7378T (96.0 %), Sphingobium xanthum NL9T (95.8 boeckii 469T (95.7 %) and LNB2T (95.5 within family...
Our objective was to investigate the relationship between E23K genetic variant in KCNJ11 gene, which encodes for Kir6.2 subunit of inward rectifier K+ channel family, and glucose insulin metabolism cardiovascular (CV) function sedentary state their responses exercise training. Two hundred fourteen healthy men women aged 50-75 years old free CV disease type 2 diabetes underwent baseline testing (maximal oxygen consumption (Vo2max), body composition tolerance). One sixty-three them repeated...
Peroxisome proliferator-activated receptors γ (PPARγ) is a master regulator that controls energy metabolism and cell fate. PPARγ2, PPARγ isoform, highly expressed in the normal prostate but at lower levels cancer tissues. In present study, PC3 LNCaP cells were used to examine benefits of restoring PPARγ2 activity. was overexpressed cells, proliferation migration detected. Hematoxylin eosin (H&E) staining detect pathological changes. The genes regulated by overexpression detected microarray...
Cancer/testis antigen (CTA) is a class of molecules expressed only in the germinal epithelium testis and some tumor tissues. As an important CTA molecule, expression F-box protein 39 (FBXO39) breast cancer (BC) its clinical significance remain unclear. The objective this study to explore value FBXO39 diagnosis, efficacy monitoring, prognostic evaluation BC.The mRNA serum exosomes patients with BC before after initial diagnosis treatment was detected by qRT-PCR, corresponding ROC curve...
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Mentha canadensis L. is an important spice crop and medicinal herb with high economic value. The plant covered peltate glandular trichomes, which are responsible for the biosynthesis secretion of volatile oils. Plant non-specific lipid transfer proteins (nsLTPs) belong to a complex multigenic family involved in various physiological processes. Here, we cloned identified protein gene (McLTPII.9) from M. canadensis, may positively regulate trichome density monoterpene metabolism. McLTPII.9 was...
Objective To explore the effects of small interfering RNA (siRNA) specific to Bcl-2gene on radiosensitivity esophageal cancer cells. Methods Bcl-2 gene siRNA ( ) was induced into EC9706 cells by lipofectamine. protein expression and apoptosis were detected flowcytometer. Clone forming assay used determine inhibitory X-ray radiation combined with interference. Results When had been cells, in inhibited, cell increased. rates siRNA1, A2, A3 (25.13％ ±2. 04％ ,38.87％ ± 3.34％ , 30.55％ 2. 73％ lower...