A5038013809- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Microbial Metabolism and Applications
- Influenza Virus Research Studies
- Bacterial Infections and Vaccines
- Global Maternal and Child Health
- Antimicrobial Resistance in Staphylococcus
- Fungal Infections and Studies
- Neonatal and Maternal Infections
- HIV/AIDS Research and Interventions
- Viral gastroenteritis research and epidemiology
- HIV-related health complications and treatments
- Bacterial Identification and Susceptibility Testing
- Mycobacterium research and diagnosis
- Sepsis Diagnosis and Treatment
University of the Witwatersrand
2019-2024
Stellenbosch University
2024
National Health Laboratory Service
2019-2023
Background Globally, over 400,000 neonatal deaths in 2015 were attributed to sepsis, however, the incidence and etiologies of these infections are largely unknown low-middle income countries. We aimed determine etiology community-acquired early-onset (<72 hours age) sepsis (EOS) using culture molecular diagnostics. Methods This was a prospective observational study, which we conducted surveillance for pathogens combination blood polymerase chain reaction (PCR)-based test. Blood performed on...
Abstract We enrolled 1323 hospitalized infants aged &lt;1 year in 2016–2018, and examined the association between HIV status in-hospital mortality. After controlling for confounders, HIV-exposed uninfected did not have an increased risk of mortality, whereas living with had 4 times greater compared HIV-uninfected infants.
We describe the use of a multipathogen platform, TaqMan array card (TAC) real-time polymerase chain reaction, for detection pathogens in patients hospitalized with severe respiratory illness (SRI).Prospective hospital-based syndromic surveillance acute and chronic SRI was carried out at two sentinel sites South Africa between January December 2017. tested specimens 21 blood samples nine bacteria using TAC. Pathogen compared by age group HIV status chi-square test.During 2017, 956 all ages...
Background: Delayed or incorrect treatment of meningitis may result in adverse patient outcomes. However, laboratory testing resource-limited settings is often limited to conventional diagnostic methods. We explored the utility syndromic molecular assays for diagnosis.Objectives: tested cerebrospinal fluid (CSF) specimens collected from patients with clinically suspected submitted a tertiary hospital January 2021 – May 2021. Primary microbiological analysis (culture, Gram stain and...
Abstract Background Pneumonia continues to be a leading cause of death globally; however, in >50% cases, an etiological agent is not identified. We describe the use multi-pathogen platform, TaqMan array card (TAC) real-time PCR, for detection pathogens patients hospitalized with severe respiratory illness (SRI). Methods conducted prospective hospital-based surveillance SRI among at two sentinel sites South Africa between January and December 2017. Patients were included this study if...