A5090247671- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Viral Infections and Outbreaks Research
- COVID-19 Clinical Research Studies
- Thermal Regulation in Medicine
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Global Public Health Policies and Epidemiology
- Non-Invasive Vital Sign Monitoring
- Genetics, Bioinformatics, and Biomedical Research
- Intramuscular injections and effects
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Health and Conflict Studies
- Platelet Disorders and Treatments
- Respiratory Support and Mechanisms
- Healthcare Policy and Management
- Pharmacovigilance and Adverse Drug Reactions
- Bacillus and Francisella bacterial research
- Primary Care and Health Outcomes
- HIV-related health complications and treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- COVID-19 and Mental Health
- COVID-19 and healthcare impacts
- Heart Rate Variability and Autonomic Control
Informa Healthcare
2022
Right to Care
2019
We aimed to assess the effectiveness of a single dose Ad26.COV2.S vaccine (Johnson & Johnson) in health-care workers South Africa during two waves African COVID-19 epidemic.
Abstract Following the results of ENSEMBLE 2 study, which demonstrated improved vaccine efficacy a two-dose regimen Ad26.COV.2 given months apart, we expanded Sisonke study had provided single dose to almost 500 000 health care workers (HCW) in South Africa include booster Ad26.COV.2. enrolled 227 310 HCW from 8 November 17 December 2021. Enrolment commenced before onset Omicron driven fourth wave affording us an opportunity evaluate early VE preventing hospital admissions homologous boost...
Both vaccination and physical activity have been shown to independently decrease the likelihood of severe COVID-19 infection.To assess association between regular against among healthcare workers.A test negative case-control study design was used estimate risk having an associated COVID-19-related hospital admission, individuals who were unvaccinated compared with those fully vaccinated Ad26.COV2.S (>28 days after a single dose). 196 444 participant tests stratified into three measured...
Background Integrase inhibitors, including dolutegravir, may increase risk of major adverse cardiovascular events (MACEs). However, limited data exists from low- and middle-income countries, where tenofovir disoproxil fumarate, lamivudine dolutegravir (TLD) has largely replaced emtricitabine efavirenz (TEE). Methods We used de-identified a South African managed-healthcare organisation people living with HIV (PLHIV) without disease, who either initiated TEE or TLD between April 2020-Dec 2023...
The phenomenon of silent hypoxaemia has been described in patients with COVID-19 pneumonia, which is characterised by low oxygen saturation levels <90% those who appear clinically well and do not show signs significant respiratory distress. To assess the impact on clinical outcomes for high-risk using a pulse oximeter to monitor home setting. We performed retrospective cohort analysis data from large South African insurance administrator. Patients were categorised as high risk, based age...
To assess the rates of vascular thrombotic adverse events in first 35 days after one dose Ad26.COV2.S vaccine (Janssen/Johnson & Johnson) healthcare workers South Africa and to compare these with those observed general population.Open label, single arm, phase 3B study.Sisonke study, Africa, 17 February 15 June 2021.The Sisonke cohort 477 234 workers, aged ≥18 years, who received vaccine.Observed venous arterial thromboembolism induced immune thrombocytopenia thrombosis individuals were...
Healthcare delivery systems around the world are designing care through value-based models where value is defined as a function of quality outcomes and cost. Mortality sentinel outcome measure care, fundamental importance to patients providers. Discovery Health (DH), an administrative funder healthcare in South Africa (SA), uses service claims data client medical schemes examine standardised mortality rates (SMRs) at condition level across hospital for purpose system improvement. To...
Background: A phenomenon of silent hypoxaemia has been described in patients with COVID-19 pneumonia, which is characterised by low oxygen saturation levels < 90% who appear clinically well and do not show signs significant respiratory distress. We assessed the impact on clinical outcomes for high-risk using a pulse oximeter to monitor home setting.Methods: performed retrospective cohort analysis data from large South African insurance administrator. Patients were categorised as high risk,...
Background: The Sisonke phase 3B open-label implementation study vaccinated health care workers (HCWs) with the single dose Ad26.COV2.S vaccine during two phases of South African COVID-19 epidemic, dominated first by Beta followed Delta variant concern.Methods: HCWs were over 3 months (17 February -17 May 2021). Vaccine effectiveness (VE) against related hospitalisation, hospitalisation requiring critical or intensive and death, ascertained 28 days more post vaccination was assessed up until...
Background. In the absence of more recent national data on underlying causes death in South Africa (SA), we examined mortality trends from 2010 to 2022 among members a large private medical scheme. This analysis sheds light health profile this specific demographic. Objective. To investigate Discovery Health Medical Scheme (DHMS) members’ rates and cause patterns between 2022. Methods. All-cause deaths were compared across years accounting for demographic changes, by analysing age-...
Data science explores the use of big data to gain deeper insights and generate new knowledge innovations which can lead economic growth sustainable development.However, setting up research comes with challenges.How we engage stakeholders is a major factor that determines success.This Commentary highlights important considerations for stakeholder engagement based on experiences investigators in health discovery project underway Nigeria South Africa.The perspectives presented will guide...