A5020795952- Vestibular and auditory disorders
- Ophthalmology and Eye Disorders
- Glaucoma and retinal disorders
- Visual perception and processing mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Tactile and Sensory Interactions
- American Sports and Literature
- Ophthalmology and Visual Impairment Studies
- Amphibian and Reptile Biology
- Species Distribution and Climate Change
- Hearing Loss and Rehabilitation
- Motor Control and Adaptation
- Advanced Optical Imaging Technologies
- Gaze Tracking and Assistive Technology
- Neuroscience and Neuropharmacology Research
- Lepidoptera: Biology and Taxonomy
- Neuroscience of respiration and sleep
- Electromagnetic Fields and Biological Effects
- Balance, Gait, and Falls Prevention
- Ocular Surface and Contact Lens
- Hemispheric Asymmetry in Neuroscience
- Insurance, Mortality, Demography, Risk Management
- Animal Genetics and Reproduction
- Fusion and Plasma Physics Studies
- Probability and Risk Models
Johns Hopkins Medicine
2014-2025
Johns Hopkins University
2016-2025
University of Baltimore
2022
University of Wisconsin–Madison
1987-2021
University of California, Los Angeles
2021
York University
2021
University of Utah
2021
Wonkwang University
2016
WinnMed
2014
Institut für Urheber- und Medienrecht
2014
Vestibular and oculomotor research often requires measurement of 3-dimensional (3D) eye orientation movement with high spatial temporal precision accuracy. We describe the design, implementation, validation use a new magnetic coil system optimized for recording 3D movements using small scleral coils in animals.Like older systems, design uses off-the-shelf components to drive three mutually orthogonal alternating fields at different frequencies. The voltage induced by those is decomposed into...
In five normal subjects, we analyzed uncalled for torsion (blips) during and after horizontal vertical saccades. Torsion was defined as movement out of Listing's plane. During saccades in downward gaze the abducting eye extorted adducting intorted. The direction blips reversed upward gaze. Peak torsional amplitudes (up to 1–2 deg) were always reached saccades; drifts back plane outlasted extorting larger than that intorting eye, producing a transient positive cyclovergence. cyclovergence...
BACKGROUNDBilateral loss of vestibular (inner ear inertial) sensation causes chronically blurred vision during head movement, postural instability, and increased fall risk. Individuals who fail to compensate despite rehabilitation therapy have no adequate treatment options. Analogous hearing restoration via cochlear implants, prosthetic electrical stimulation nerve branches encode motion has garnered interest as a potential treatment, but prior studies in humans not included continuous...
Objective: Development of an easy to administer, low-cost test vestibular function. Methods: Members the NIH Toolbox Sensory Domain Vestibular, Vision, and Motor subdomain teams collaborated identify 2 tests: 1) Dynamic Visual Acuity (DVA), 2) Balance Accelerometry Measure (BAM). Extensive work was completed develop appropriate software hardware. More than 300 subjects between ages 3 85 years, with without dysfunction, were recruited tested. Currently accepted gold standard measures static...
Torsional eye movements are rotations of the around line sight. Measuring torsion is essential to understanding how brain controls position and it creates a veridical perception object orientation in three dimensions. Torsion also important for diagnosis many vestibular, neurological, ophthalmological disorders. Currently, there multiple devices methods that produce reliable measurements horizontal vertical movements. torsion, however, noninvasively reliably has been longstanding challenge,...
Gaze stability exercises are a critical component of vestibular rehabilitation for individuals with hypofunction and many studies reveal the improves functional performance. However, few have examined physiologic mechanisms (semicircular canal; otolith) responsible such recovery after patients complete gaze gait exercises. The purpose this study was to compare behavioral outcome measures (i.e., visual acuity during head rotation) physiological gain vestibulo-ocular reflex) following...
Abstract Background High-field magnetic resonance imaging (MRI) is a powerful diagnostic tool but can induce unintended physiological effects, such as nystagmus and dizziness, potentially compromising the comfort safety of individuals undergoing imaging. These effects likely result from Lorentz force, which arises interaction between MRI's static field electrical currents in inner ear. Yet, force hypothesis fails to explain observed eye movement patterns healthy adults fully. This study...
Zebrafish (Danio rerio) offer advantages as model animals for studies of inner ear development, genetics and ototoxicity. However, traditional assessment vestibular function in this species using the vestibulo-ocular reflex requires agar-immobilization individual fish specialized video, which are difficult labor-intensive. We report that a static magnetic field to directly stimulate zebrafish labyrinth results an efficient, quantitative behavioral assay free-swimming fish. recently observed...
We recently discovered that static magnetic fields from high-strength MRI machines induce nystagmus in all normal humans, and a magneto-hydrodynamic Lorentz force, derived ionic currents the endolymph pushing on cupula, best explains this effect. Individuals with no labyrinthine function have nystagmus. The influence of vestibular stimulation (MVS) individuals unilateral deficits is unknown may provide insight into mechanism MVS. These should experience MVS, but different pattern consistent...
As part of the National Institutes Health Toolbox initiative, we developed a low-cost, easy-to-administer, and time-efficient test vestibular visual function. A computerized dynamic acuity (cDVA) was used to measure difference in between head still moving yaw. Participants included 318 individuals, aged 3 85 years (301 without 17 with pathology). Adults Early Treatment Diabetic Retinopathy Study (ETDRS) optotypes; children ETDRS, Lea, HOTV optotypes. Bithermal calorics, rotational chair,...
Sensory pathways provide complex and multifaceted information to the brain. Recent advances have created new opportunities for applying our understanding of brain sensory prothesis development. Yet sensor physiology, limited numbers electrodes, nonspecific stimulation proven be a challenge many systems. In contrast, vestibular system is uniquely suited prosthesis Its peripheral anatomy allows site-specific 3 separate organs that encode distinct directions head motion. Accordingly, here, we...
Introduction Dizziness is a growing public health concern with as many 95 million adults in Europe and the United States experiencing vestibular hypofunction, which associated reduced quality of life, poorer health, falls. Vestibular rehabilitation therapy (VRT) effective reducing symptoms improving balance; however, limited access to qualified clinicians poor patient adherence impedes optimal delivery. The goal this study was develop evaluate feasibility remote therapeutic monitoring VRT...
From animal experiments by Cohen and Suzuki et al. in the 1960s to first-in-human clinical trials now progress, prosthetic electrical stimulation targeting semicircular canal branches of vestibular nerve has proven effective at driving directionally appropriate vestibulo-ocular reflex eye movements, postural responses, perception. That work was considerably facilitated fact that all hair cells primary afferent neurons each have same directional sensitivity head rotation, three canals’...
Abstract 7‐Tesla (T) magnetic resonance imaging may allow for higher resolution images but produce greater acoustic noise than 1.5‐ and 3‐T scanners. We sought to characterize the intensity of from 7‐ versus A‐weighted sound pressure levels 5 types pulse sequences used brain inner ear in 3‐ 7‐T scanners were measured. Time‐averaged level maximum generated each sequence compared. exceeded 95 dB reached maximums above 105 on majority scans. The mean time‐averaged across (105.6 vs 91.4, P =...
Patients and technologists commonly describe vertigo, dizziness, imbalance near high-field magnets, e.g., 7-Tesla (T) magnetic resonance imaging (MRI) scanners. We sought a simple way to alleviate vertigo dizziness in MRI scanners by applying the understanding of mechanisms behind vestibular stimulation innate characteristics adaptation.